Capabilities
MANUFACTURING SITES
LONDON, UK PCR / qPCR Assay Development RNA Analysis DNA MW Marker Mfg
MEMPHIS,TN Viral Antigens
Recombinant Proteins In Vitro Antibody Mfg HAMA Blocking Agents Antibody Purification Contract R&D and PD Cell and Viral Banking cGMP Vaccine Mfg
BERLIN, DE Large Scale Nucleotides Mfg PCR Enzyme Mfg Protein Expression and Purification DNA MW Markers
BOCA RATON, FL Ascites Production Large Scale MAb Mfg 55,000 Mice (BALB/c, CAF1)
SYDNEY, AUS Competent Cells Mfg Diagnostic Extraction Controls
Parent Company: Meridian Bioscience, Inc. Diagnostic Test Kits | Founded in 1977; IPO in 1986 | Nasdaq: VIVO Headquartered in Cincinnati, OH | Employees: 500+ | International Presence, 60+ countries
OVERVIEW OF CAPABILITIES
PRODUCTION SYSTEMS Tissue culture flasks Spinner flasks Roller bottles (smooth and ribbed) Cell factories WAVE Bioreactors TM Fermentors
EXPRESSION SYSTEMS Mammalian (CHO, Vero, NS0, etc.) Bacterial ( E.coli ) Yeast ( P. pastoris, S. cerevisiae, etc.) Baculovirus in Sf9 Egg-based Virus Production Vaccinia & Adeno
PURIFICATION METHODS Ultrafiltration Diafiltration TFF (plate or hollow fiber)
Centrifugation/ultracentrifugation ÄKTA FPLC systems for SEC, Affinity, Ion exchange, HIC Dialysis, ultracentrifugation, tangential flow Expanded bed chromatography Centrifugation, gradient centrifugation Microfluidization, freeze/thaw, chemical lysis
QUALITY CONTROL AND ANALYTICAL TESTING Mature quality system with dedicated QA/QC and Regulatory team In-house testing (e.g. protein concentration, HPLC, ELISA, SDS-PAGE, Western blot) ISO 9001 Quality System Regulations - Applicable sections of 21 CFR 820 Current Good Manufacturing Practices - Applicable Sections of 21 CFR 210, 211
WAVE is a trademark of GE Healthcare
www.MeridianLifeScience.com
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