Human Papilloma Virus (HPV) Antigen Detection Assays
| Continued
Diagnosis Traditionally, genital HPV infection is detected by a Pap smear and does not distinguish between high- and low-risk types. There are several DNA HPV tests, some of which are approved for marketing by the FDA, that can detect high-risk types of HPV. However in developing countries where more than 85% of cervical cancer deaths occur, the resources, infrastructure, and technological expertise and the need for repeated screening at frequent intervals, have made conventional molecular and cytology-based (Pap smear) screening prohibitively difficult. Ideally, screening tests suitable for low resource settings should be simple, rapid, cost effective and provide information regarding the HPV oncogenic activity. Research has demonstrated that both HPV E6 and E7 oncoproteins mediate the development of cervical cancer. Their overexpression, which can be measured by mRNA transcripts or detection of the expressed proteins, directly correlates with the severity of cervical histopathology and the risk for precanerous progression. Accordingly, many commercial assays have been developed for the detection of precancerous high-risk HPV 16 and HP18 E6 and E7 proteins, in which positive results are suggestive of an increased risk of cervical cancer.
Reagents for serology testing MAb to HPV 18 (E7) • Reactive with HPV Type 18, E7 protein C86718M
Paired MAbs for Sandwich ELISA Antigen Detection Assays Suitable for use in ELISA, RIA and IFA Antigen Detection Assays
• Does not cross-react with E7 protein of HPV type 16 • Isotype: IgG1 • Capture antibody
MAb to HPV 16 (E7) • Reactive with HPV Type 16, E7 Protein • Isotype: IgG2a
MAV56-013
MAV56-981
MAb to HPV 16 (L1) • Reactive with HPV Type 16, L1 (Major Capsid Protein) • Isotype: IgG2a MAb to HPV 16 (L1) • Reactive to beta galactosidease-L1 protein • Isotype: IgG2a
Suitable for use in IHC Antigen Detection Assays
MAV56-981T
Suitable for use in IHC and Western Blot Antigen Detection Assays
MAV56-965
MAb to HPV 18 (E6) • Reactive with the E6 of HPV Type 18 and Type 16 • Isotype: IgG1
Sexually Transmitted Diseases (STDs)- Reagents for Assay Development 17
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