Sexually Transmitted Diseases (STDs)

Neisseria gonorrhoeae Antigen Detection Assays

Neisseria gonorrhoeae is gram-negative bacteria that causes infections in the urethra, cervix, vagina or anus. It is one of the two most common STDs in the United States along with chlamydia. If left untreated, gonorrhea infections can spread in the reproductive tract, causing prostatitis and epididymitis in men, or pelvic inflammatory disease (PID) in women.

MORPHOLOGY OF N. GONORRHOEAE

The World Health Organization (WHO) estimates that there are 88 million new cases of gonorrhea each year. It is common for infected individuals to not have any symptoms and unknowingly spread the disease. Asymptotic infections along with the emergence of multidrug-resistant N. gonorrhoeae , present a significant challenge in controlling gonorrhea.

If left untreated, gonorrhea may last for weeks or months with a high risks of complications. Significant problems include: infertility in both men and women, infection in the joints and other areas of the body, and an increased risk for HIV/AIDS. Women with gonorrhea infections before or during pregnancy are also at increased risk for pregnancy complications such as stillbirth and premature birth. In addition, babies can become infected with gonorrhea during the birth process, leading to eye and joint infections and possible life-threatening blood infections. Men who have had a gonorrhea infection have a significantly increased risk of having prostate cancer. Diagnosis Traditionally, gonorrhea is diagnosed with gram stain and culture as they have 100% specificity; however, newer rapid antigen detection assays are needed as alternatives. Significant disadvantages of culture include variable sensitivity, complex logistics, and slow turnaround times and new tests need to have improved sensitivity, ease of handling, and rapid processing. All gonorrhea tests use a sample of body fluid from the affected area.

Reagents for serology testing

C01818M C01819M C01820M

MAb to Neisseria gonorrhoeae • Reactive with 9 strains of N. gonorrhoeae , N. lactamica and N. Meningitidis • Non-reactive with N. mucosa , N. perflava , N. sicca , G. vaginalis , group B Streptococcus, Candida albicans , Hemophilus influenza type B, C. trachomatis , T. vaginalis , M. genitalium , U. urealyticum and HSV-2 PAb to Neisseria gonorrhoeae • Produced in rabbits using immunogen of whole N. gonorrhoeae (ATCC 31426) • Specific for all antigens • Antiserum is not absorbed and may react with related microorganisms • >95% pure, purified by Protein A chromatography

Suitable for use in ELISA and IFA Antigen Detection Assays

B65111R

Suitable for use in ELISA and IFA Antigen Detection Assays