Hormones & Steroids

Calcitonin

Calcitonin is a polypeptide hormone that is produced by the C-cells of the thyroid gland and it acts to reduce blood calcium and phosphate levels, opposing the effects of Parathyroid Hormone (PTH). Calcium is an essential structural component of the skeleton and plays a key role in muscle contraction, blood coagulation, enzyme activity, neural excitability, secondary messengers, hormone release, and membrane permeability. Three major hormones (PTH, vitamin D, and calcitonin) interact to maintain a constant concentration of calcium in the body.

Calcitonin is measured using quantitative sandwich immunoassays that employ MAbs for the recognition of intact and mature calcitonin. High levels of calcitonin identify patients with nodular thyroid diseases and diagnose medullary thyroid cancers which originate from the C-cells of the thyroid gland. Medullary tumors are the third most common of all thyroid cancers.

Reagents for Immunoassay Development

E01357M

MAb to Calcitonin • Produced in Cell Culture • Capture Antibody MAb to Calcitonin • Produced in Cell Culture • Detection Antibody

Suitable for use in CLIA, ELISA & RIA

E01356M

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Endocrine Disorders - Reagents for Assay Development

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