Thyroglobulin (Tg) Thyroglobulin (Tg) is a dimeric protein produced by the follicular cells of the thyroid and accounts for approximately half of the protein content of the thyroid gland. It is the precursor for the thyroid hormones T3 and T4 and each Tg molecule forms approximately 10 thyroid hormone molecules. The major clinical use of a Tg diagnostic test is to monitor patients with well- differentiated thyroid cancers (particularly papillary or follicular thyroid cancer). The measurement of thyroglobulin, after thyroidectomy and ablation of the thyroid gland, is useful to determine metastasis. Tg assays can also be used to detect deficient Tg synthesis in infants with goitrous hypothyroidism, which is a preventable cause of mental retardation. Tg serum levels are measured by two-site sandwich immunoassays. However, quantitative Tg serum assays are prone to interference from endogenous circulating autoantibodies (anti-Tg) and can cause inappropriately low Tg results in about 20% to 30% of patients. In suspected cases of interference, a confirmatory test detecting the presence of anti-Tg should be carried out.
Reagents for Immunoassay Development
MAb to Thyroglobulin • Specifically recognizes human thyroglobulin • Cross-reacts with bovine thyroglobulin. • Does not interfere with anti-thyroglobulin autoantibodies • Capture Antibody MAb to Thyroglobulin • Specifically recognizes human thyroglobulin. • Does not interfere with anti-thyroglobulin autoantibodies • Detection Antibody Thyroglobulin Native Antigen • Purified from human thyroid extract • >90% pure (SDS-PAGE) • Lyophilized from 25 mM Tris-HCl, pH 8.0
Suitable for use in ELISA
Endocrine Disorders - Reagents for Assay Development
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