Hormones & Steroids

Aldosterone Aldosterone is a steroid hormone produced by the adrenal cortex that plays an important role in cardiac health and can be a cause of endocrine hypertension. It is essential for sodium conservation in the kidney, salivary glands, sweat glands and colon, and is involved in the homeostatic regulation of blood pressure, plasma sodium (Na + ), and potassium (K + ) levels. Aldosterone is closely linked to two other hormones, renin and angiotensin, and together these are the renin-angiotensin-aldosterone system. This system is activated when the body experiences a decrease in blood flow to the kidneys, such as after a drop in blood pressure, or a significant drop in blood volume after a hemorrhage or serious injury. Primary aldosteronism (Conn syndrome) is caused by the overproduction of aldosterone by the adrenal glands, usually from a benign tumor or a genetic disorder (familial hyperaldosteronism). The high aldosterone level increases reabsorption of sodium and loss of potassium by the kidneys, often resulting in an electrolyte imbalance. Secondary aldosteronism, which is more common than primary aldosteronism, is caused by anything that leads to excess aldosterone, other than a disorder of the adrenal glands. It could be caused by any condition that decreases blood flow to the kidneys, decreases blood pressure, or lowers sodium levels. Secondary aldosteronism may be seen with congestive heart failure, cirrhosis of the liver, kidney disease and toxemia of pregnancy (pre-eclampsia). Low aldosterone (hypoaldosteronism) usually occurs as part of adrenal insufficiency. It causes dehydration, low blood pressure, a low blood sodium level, and a high potassium level. When infants lack an enzyme needed to make cortisol, a condition called congenital adrenal hyperplasia, they may not be able to produce enough aldosterone. Aldosterone and renin tests are generally ordered together to evaluate whether the adrenal glands are producing appropriate amounts of aldosterone and to distinguish between the potential causes of excess or deficiency. Typically they are quantitative plasma or serum assays that are based on competitive EIA principles. Reagents for Immunoassay Development

E30451M

MAb to Aldosterone • Cross-reactivity: Androstenedione (<0.01%), Corticosterone (<0.01%), & Desoxycorticosterone (<0.01%)

Suitable for use in ELISA

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