Anti-Müllerian Hormone (AMH) A new serum marker that provides the most accurate assessment of ovarian reserve
The measurement of anti-müllerian hormone (AMH) has gained widespread interest as an indicator of ovarian function and menopausal transition. It is a hormone made by the small follicles in the ovary and circulating levels of AMH positively correlate with the number of remaining ovarian follicles. The AMH assay is quickly becoming a routine test in determining ovarian reserve, identifying hyper-stimulation syndrome in women undergoing in vitro fertilization (IVF), and in diagnosing polycystic ovary syndrome. AMH is a member of the transforming growth factor β family and is expressed by granulosa cells of the ovary during a female’s reproductive years. AMH serum levels serve as a biomarker for relative capacity of the ovarian reserve and consequently, AMH is considered an extremely sensitive marker of ovarian aging. In addition, AMH evaluation is of clinical importance in predicting the success of in vitro fertilization (IVF) and can be used as a surrogate diagnostic marker of polycystic ovary syndrome in cases in which ultrasonographic examination is not possible.
The AMH gene is located on chromosome 19 and encodes an inactive homodimer precursor of identical disulfide-linked 70-kDa glycoproteins. Each monomer contains a pro-region (pro-AMH or N-terminal) and a C-terminal domain (also called the “mature” region) which is cleaved at monobasic sites between the two domains. After cleavage, the pro-region (110-kDa) and C-terminal (25 kDa) homodimers remain associated in a noncovalent complex that bind to AMH Receptor II and activate signaling.
Anti-Müllerian Hormone (AMH) Protein Structure
Pro-AMH (N-Terminal)
Mature (C-Terminal)
Cleavage (a.a. 451)
Figure based from C. Heule, W. Salzburger, and A. Böhn, Genetics. 196: 579–591 (2014)
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MERIDIAN ANTI-MÜLLERIAN HORMONE ANTIBODIES AND ANTIGENS
MONOCLONAL ANTIBODIES
PAIRING INFORMATION
Sandwich Assay Capture MAb Detection MAb Recombinant Antigen 9602 9603 9604 E01347M E01348M R01712 E01349M E01350M R01713 E01352M E01353M - E01354M E01355M -
• Specific for AMH • Suitable for use in ELISA, CLIA and LF assays E01347M E01353M E01348M E01354M E01352M E01355M • Suitable for use in ELISA and CLIA assays 9602 9603 E01349M E01350M
Competitive Assay Antibody
Antigen
E01347M E01349M
R01713 R01713
RECOMBINANT ANTIGENS
9604
• Rec. AMH Antigen • Produced in insect cells • Suitable for use in ELISA and WB
R01712 • Rec. AMH Antigen R01713 • Produced in E.coli
• Suitable for use in sandwich and competitive ELISAs and WB.
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