In the fast-paced world of healthcare, advancements in diagnostic technologies are shaping the way we identify and combat diseases. Traditional diagnostic testing is commonly characterized by costly and time-consuming processes, from sample collection to result interpretation, leading to delays in critical decision-making for patient care. High- throughput platforms, however, prioritize speed without compromising accuracy and can process large volumes of samples in a relatively short timeframe. As technology continues to advance, high-throughput platforms will evolve and reshape the landscape of healthcare, making diagnostics more cost-efficient, efficient, and precise.
High-throughput molecular diagnostic platforms require specific reagent solutions that are highly sensitive and specific, fast, stable, and enable a simplified workflow. Some key features beneficial for high throughput assays are glycerol-free and high-concentration formulations that maximize sample input for greater assay flexibility and ensure precision in liquid handling. In addition, reagent stability at room-temperature enables benchtop reaction set-up and storage, improving the overall workflow efficiency of an assay.
Benefits of Glycerol-Free Formats • Compatible with lyophilization • Compatible with air-drying • Ambient temperature and on-board instrument stability
Advantages to Glycerol-free and High-Concentration Enzymes
Benefits of High-Concentration Reagents • Maximize sample input • Smaller reaction volumes
Meridian has developed high-concentration, glycerol-free enzymes and master mixes to streamline high-throughput assay development, minimizing manufacturing time and enhancing user-friendliness. These optimized mixes aim to reduce sample variation and background noise, accelerate reactions, and maintain sensitivity levels. They feature glycerol-free enzymes and mastermixes for consistent performance, even in the presence of PCR inhibitors. Some mixes include dUTP to insure compatibility with UDGase system when required. Moreover, Meridian’s glycerol- free reagents are compatible with automated liquid handling and can be lyophilized or air-dried for stable ambient shipment and storage. Additionally, high-concentration enzyme formats are available, enabling greater sensitivity and flexibility in assay development while maximizing sample utilization.
• Greater flexibility in assay optimization
Benefits of Preoptimized Master Mixes • Robustness, minimizing sample to sample variation • Speed, faster development and faster time to results
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