COVID-19

SARS-CoV-2 Recombinant Antigens

For Serology Antibody Assays

Serologic tests are an important tool for monitoring the evolution of an outbreak. Specifically, IgG/IgM antibody tests are essential for identifying previously undiagnosed infections in the asymptomatic population. Meridian’s recombinant antigens are expressed in human mammalian cells and insect cells using proprietary expression and purification technologies. Expression in either human or insect cells provides for post-translational modifications such as glycosylation and phosphorylation which can offer significant performance advantages over E. coli expressed formats.

Wild-type SARS-CoV-2

Mutant SARS-CoV-2 Spike, S1 RBD

Trimeric Spike, S1 Protein (His-Tag) Represents amino acids 14 - 683 of SARS-CoV-2 plus the synthetic trimeric domain Spike Protein, S1 Subunit (His-Tag) Represents amino acids 14 - 683 of the SARS-CoV-2 S1 subunit Spike Protein, N-terminal Domain (NTD) S1 Subunit (His-Tag) Represents amino acids 16 - 305 of the SARS-CoV-2 N-terminal domain Spike Protein, S1 Subunit RBD (His-Tag) Represents amino acids 330 - 521 of the SARS-CoV-2 S1 subunit, RBD domain

Omicron mutant (B.1.1.529.1) Represents Omicron variant with 15 mutations on the RBD

9544

9566

L452R and T478K mutant (His-Tag) Represents B.1.617.2 (Delta Variant), a.a. 319 - 541

9606

9556

N501Y mutant (His-Tag) Represents B.1.1.7 strain, (Alpha variant) a.a. 319 - 541 K417N, E484K and N501Y mutant (His-Tag) Represents B.1.351 strain, (Beta variant) a.a. 319 - 541 K417T, E484K and N501Y mutant (His-Tag) Represents P.1 strain, (Gamma variant) a.a. 319 - 541

9567

9557

9568

9558

9569

9560

Nucleocapsid Protein (His-Tag)

L452R mutant (His-Tag) Represents Epsilon variant, a.a. 319 - 541

9598

9552

Spike Protein, S1 Subunit RBD (His-Tag)

L452R and E484Q mutant (His-Tag) Represents B.1.167 strain (Kappa variant), a.a. 319-541

9599