Gastrointestinal Pathogens for Stool Testing

Gastrointestinal Pathogens for Stool Testing ANTIBODIES & ANTIGEN CONTROLS USED IN STOOL ANTIGEN DETECTION ASSAYS

Meridian offers a range of antibodies and antigens for use in various immunoassays to detect gastrointestinal pathogens. These products are currently being used in validated, commercial diagnostic assays to detect pathogens from stool samples

COMMON GASTRO PATHOGENS • Adenovirus • Astrovirus • Calprotectin

• Giardia lamblia • Helicobacter pylori • Lactoferrin • Listeria monocytogenes • Norovirus • Rotavirus • Salmonella • Shigella • Verotoxin • Yersinia enterocolitica

• Campylobacter coli • Campylobacter jejuni • Clostridium difficile • Cryptosporidium parvum • E. coli O157 • Entamoeba species • Enterovirus

DIAGNOSTICS FOR ACUTE GASTROENTERITIS

Acute gastroenteritis is a common syndrome that is generally caused by a virus, parasite or food-borne bacteria. Diagnosis of the responsible intestinal pathogen requires the detection of the organism in the feces, duodenal fluid, or small intestine using biopsy specimens. Since fecal examination is labor intensive and requires a skilled microscopist, antigen detection tests have been developed as alternatives using immunofluorescent assays (IFA), enzyme immunoassay (EIA), and rapid diagnostic tests (RDTs) in various formats. Some of these immunoassays are quick to perform, do not require skilled personnel and are very specific. There are many commercially available diagnostics for a range of gastrointestinal pathogens, including panel assays that simultaneously test for a range of possible infectious agents using a single stool sample.

Large panel of matched antibody pairs Antigens available for use as controls

Pairs demonstrated to work in ELISA, LF or both All suitable for development in stool based assays

www.meridianbioscience.com/lifescience

ANTIBODIES FOR STOOL TESTING

Adenovirus Hexon C11994M

Clostridium difficile Toxin B C65427M ELISA C65423M ELISA, LF, pair C65426M ELISA, LF, pair Cryptosporidium parvum C65370M ELISA, IFA, IHC C01948M LF, pair E. coli O157 C65160M ELISA, IFA C01533M ELISA, IFA, pair C01535M ELISA, IFA, pair C01958M LF, pair Entamoeba histolytica & dispar C01945M LF, pair Giardia lamblia C01597M ELISA, IFA, WB C01950M (trophozoite) LF, pair C01949M (trophozoite) LF, pair C65361M ELISA, IFA, WB, pair C65612M ELISA, IFA, WB, pair Helicobacter pylori C65461M ELISA, IFA, WB C01956M LF, pair Lactoferrin H01412M LF, pair H01411M LF, pair Norovirus GI Capsid C01871M ELISA, LF, WB, pair C01872M ELISA, LF, WB, pair C01875M ELISA, WB, pair Norovirus GII Capsid C01877M ELISA, LF, WB, pair C01878M ELISA, pair C01879M ELISA, LF, WB, pair C01880M ELISA, LF, WB, pair

Rotavirus C65194M

ELISA, LF

ELISA, LF, pair ELISA, LF, pair ELISA, LF, pair ELISA, LF, pair ELISA, LF, pair

C01727M C01728M C01554M C01256M C65431M C65604M C01953M

ELISA, LF, pair ELISA, LF, pair

C65196M C65197M C01729M C01730M

ELISA, LF, IFA, pair ELISA, LF, IFA, pair ELISA, LF, IFA, pair ELISA, LF, IFA, pair

Rotavirus Group A Specific Antigen, VP6 C66130M ELISA Salmonella C01918M

LF, pair

Adenovirus 40 & 41 C66431M ELISA Astrovirus C01981M

ELISA, IFA, LF, pair

Salmonella species (A,B,C,D,E,F & G Groups) C65957M ELISA, IFA C01360M ELISA, IFA Salmonella paratyphi A C01884M ELISA, IFA C01921M ELISA, IFA, pair Salmonella typhi (LPS) C01362M ELISA, IFA, LF, pair C01919M ELISA, IFA, LF, pair Shigella B65901R ELISA, IFA Verotoxin I (Shiga-Like) B Subunit (SLT-1b, STX-1b) C01690M ELISA Verotoxin II (Shiga-like) A subunit (SLT-2a, STX-2a) C65585M ELISA, Neutralizing

ELISA, IFA, IHC, pair ELISA, IFA, IHC, pair ELISA, IFA, IHC, pair

C01982M C01983M C01984M C01955M C01954M

ELISA, pair

LF, pair LF, pair

C. coli and C. jejuni C01946M LF, pair C01947M LF, pair Calprotectin L1 K01375M ELISA K01374M ELISA K01373M

ELISA, pair ELISA, pair

K01376M

Campylobacter jejuni C66700M ELISA C65727M

ELISA, LF, WB, pair

Clostridium difficile GDH C01957M LF, pair Clostridium difficile Toxin A C70517M ELISA C01677M ELISA, pair C01678M ELISA, pair

www.meridianbioscience.com/lifescience

ANTIGENS FOR STOOL TESTING

Several antigens have been tested with antibody pairs. See page 4 for further information.

Clostridium difficile GDH R01738, E. coli LF, pair Cryptosporidium parvum A01709N, Native LF, pair E. coli 0157 A01718N, Native LF R01741, E. coli LF R01742, E. coli LF

Listeria monocytogenes A01710N LF Norovirus GI R01731, E. coli LF R01730, E. coli LF R01744, Insect LF Norovirus GII R01732, E. coli LF R01733, E. coli LF R01734, E. coli LF R01745, E. coli LF Rotavirus R01728, E. coli LF Salmonella A01699N, Native (typhi) , LF A01716N, Native (typhi) , LF A01700N, Native ( paratyphi A), LF A01701N, Native ( paratyphi B), LF A01702N, Native ( enteritidis ), LF Shigella A01704N, Native (boydii) , LF A01705N, Native (dysenteriae) , LF A01706N, Native (sonnei) , LF A01721N, Native (flexneri) , LF Yersinia enterocolitica

Astrovirus R01729, E. coli

LF, pair

Calprotectin R01724, E. coli

LF

Campylobacter coli A01713N, Native LF, pair R01720, E. coli LF, pair

Campylobacter jejuni A01714N, Native LF, pair R01721, E. coli LF, pair Clostridium difficile Toxin A R01739, E. coli LF Clostridium difficile Toxin B R01740, E. coli LF

Entamoeba R01718, E. coli R01719, E. coli Enterovirus R01735, E. coli R01736, E. coli R01737, E. coli R01763, E. coli R01764, E. coli R01765, E. coli

(histolytica) , LF, pair

(dispar) , LF, pair

LF LF LF LF LF LF

Giardia lamblia R01723, Yeast LF R01722, E. coli

LF, pair

Helicobacter pylori A01722, Native LF, pair Lactoferrin A01712H, Native LF, pair

A01707N, Native LF A01708N, Native LF

www.meridianbioscience.com/lifescience

Antibody Pairs

CAPTURE

DETECTION ANTIGEN

APPS

C01727M C01728M C65431M C01554M C01953M C01953M C65431M C01256M C65431M C65604M

ELISA & LF ELISA & LF

Adenovirus

LF

ELISA & LF ELISA & LF

C01955M C01954M R01729

LF

C01981M C01982M C01981M C01983M C01984M C01982M C01984M C01983M K01373M K01376M

ELISA & IFA ELISA & IFA

Astrovirus

ELISA ELISA ELISA

Calprotectin L1

A01714N ( C. jejuni ) (Native) A01713N ( C. coli ) (Native)

LF LF LF LF

C. coli and C. jejuni

C01947M C01946M

R01721 ( C. jejuni OMP) (Recombinant) R01720 ( C. coli OMP) (Recombinant)

C. difficile Toxin A C. difficile Toxin B C. difficile GDH

C01678M C01677M C65423M C65426M

ELISA

LF LF

C01957M C01957M R01738

C. jejuni

C65727M C65727M

ELISA & LF

C. parvum

C01948M C01948M A01709N (Native)

LF

C01535M C01533M C01958M C01958M

ELISA

E. coli O157

LF LF LF LF

R01718 (E. histolytica) (Native) R01719 (E. dispar) (Native)

Entamoeba

C01945M C01945M

C01950M C01949M R01722 (Recombinant)

G. lamblia

C65612M C65361M

ELISA

H. pylori

C01956M C01956M A01722N H01412M H01411M A01712H (Native)

LF LF LF

Lactoferrin

C01872M C01871M C01873M C01875M C01871M C01875M C01874M C01875M C01880M C01878M C01880M C01880M C01879M C01877M C01877M C01878M C01877M C01877M C65196M C65194M C65196M C65197M C01729M C01730M C01919M C01918M C01921M C01918M C01362M C01362M

ELISA & WB

Norovirus GI Capsid

ELISA ELISA

LF LF LF

Norovirus GII Capsid

ELISA ELISA

ELISA & LF ELISA & LF ELISA & LF

Rotavirus

ELISA, IFA & LF

Salmonella

ELISA & IFA

ELISA, IFA & LF

Life Science Division 5171 Wilfong Road, Memphis, TN 38134 901-382-8716 • 800-327-6299 • info@meridianlifescience.com

July 2018

www.meridianbioscience.com/lifescience

Page 1 Page 2 Page 3 Page 4

meridianlifescience.com

Powered by