Respiratory Diseases

Bordetella pertussis A gram negative bacteria that is the causative agent of pertussis or whooping cough (an infection of the respiratory system characterized by a “whooping” sound when the person breathes in). B. pertussis has the ability to inhibit the function of the host’s immune system via its virulence factors including one toxin known as pertussis toxin. The infection occurs mostly in children under the age of one when they are unimmunized, or children with faded immunity, normally around the ages 11 through 18. Diagnostic tests include ELISA assays designed to detect IgG, IgA, or IgM specific antibodies and rapid molecular assays. Specificity Type Catalog # Host / Source Tested Apps Format Isotype Bordetella pertussis MAb C65500M Mouse EIA,IFA,WB Purified IgG3 Chlamydia pneumoniae A common species of gram-negative bacteria which is a major cause of pneumonia around the world. Seroepidemiologic studies have shown an association between C. pneumoniae infection and atherosclerosis but the significance of this is not yet established. Antibody EIA assays are the most common serology tests used for the diagnosis. A primary chlamydial infection is characterized by a predominant IgM response within 2 to 4 weeks and a delayed IgG and IgA response within 6 to 8 weeks. Specificity Type Catalog # Host / Source Tested Apps Format Isotype Chlamydia pneumoniae (TWAR strain) Ag R02620 HL Cells N/A Lysate – Chlamydia pneumoniae MAb C01369M Mouse EIA,IFA Purified IgG2b Chlamydia pneumoniae (TWAR) MAb C01844M Mouse EIA,IFA Purified IgG2b Chlamydia pneumoniae (TWAR) MAb C01843M Mouse EIA,IFA Purified IgG2b Chlamydia pneumoniae (TWAR) MAb C01842M Mouse EIA,IFA Purified IgG2b Chlamydia pneumoniae (TWAR) MAb C01841M Mouse EIA,IFA Purified IgG2b Chlamydia pneumoniae (TWAR) Ag R02620 HL Cells EIA,WB Lysate – Chlamydia pneumoniae MAb C01369M Mouse EIA,IFA Purified IgG2b Influenza Type A A highly infectious respiratory illness which can cause life-threatening secondary infections. There are three main types of influenza virus (Types A, B and C) that cause infection in humans and many sub-types which are further characterized into strains. Diagnostic influenza tests include rapid influenza diagnostic tests (RIDTs), direct fluorescent antibody stains, viral cultures and molecular assays. Many RIDTs detect the nucleoprotein (NP), which is one of the more conserved proteins in the influenza virus and subsequently less likely to undergo mutations that lead to antigenic drift. Specificity Type Catalog # Host / Source Tested Apps Format Isotype Influenza A (Victoria (H3N2)) Ag BN1119 HEK EIA, LF Purified – Influenza A (A/New Caledonia) Ag R01698 Chicken Eggs EIA Purified – Angiotensin Converting Enzyme 2 (ACE2) A metallopeptidase that functions as the receptor for SARS (severe acute respiratory syndrome) virus. It is a type I transmembrane protein with a large catalytic extracellular domain which acts as both a peptidase and a viral receptor. Specificity Type Catalog # Host / Source Tested Apps Format Isotype Angiotensin Converting Enzyme 2 (ACE2) (SARS Receptor) C-terminal PAb B88270R Rabbit EIA Aff.Pur. –