RECOMBINANT ANTIGENS FOR THE DEVELOPMENT OF ALLERGEN-SPECIFIC IgE ANTIBODY TESTS. Recombinant allergens provide new opportunities for the diagnosis of IgE-mediated allergies.
Allergy Testing
RECOMBINANT ANTIGENS FOR THE DEVELOPMENT OF ALLERGEN-SPECIFIC IgE ANTIBODY TESTS
Recombinant allergens provide new opportunities for the diagnosis of IgE-mediated allergies.
Recombinant antigens are used increasingly over native allergen extracts in the diagnosis of allergies. They are capable of binding IgE antibodies in a comparable way to natural allergens and they demonstrate good reactivity in in-vitro diagnostic tests. They offer several advantages including:
Lot-to-lot consistency: Recombinant antigens contain a defined amount of specific protein whereas allergen extracts are prone to high variability between lots in terms of the allergens present in the mix and ratio of each allergen Defined purity: Native allergen extracts contain non-allergenic compounds and can contain contaminants from other allergen sources leading to false-positive results Increased reproducibility: Assays based on recombinant allergens allow for the precise analysis of reactivity profiles of allergenic patients
Meridian’s panel of recombinant allergens is ideally suited to developing quantitative allergy tests which can determine an individual’s specific IgE-profile. These antigens are highly sensitive and specific in contrast to native allergen extracts which when used in diagnostic assays, are not able to distinguish different antibody specificities to components within that extract.
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Product List All products are suitable for use in ELISA.
Indoor Allergens:
Unlike seasonal allergies such as hay fever, indoor allergies may last all year long however, they tend to be at their worst in the late summer, when dust mites are at their peak. Sensitivity to indoor allergens is very common and occurs at every age. Typical indoor allergens include dust mites, pet dander, molds and cockroaches.
Description
Source
Molecular Weight
Product Code
Animal Epithelial Recombinant Allergens: Cat allergen (Fel d 1) P. pastoris
22kDa
R01747A
Dog allergen (Can f 5)
P. pastoris
30kDa
R01748A
Dog allergen (Can f 1)
E. coli
25 kDa
R01750A
Horse allergen (Equ c 1)
E. coli
27kDa
R01749A
Dust Mite Recombinant Allergens: Dust Mite (Der p 10) E. coli
39kDa
R01751A
Dust Mite (Der f 2)
P. pastoris
17kDa
R01752A
Outdoor Allergens:
Outdoor allergens are seasonal and are more common during the spring and summer and tend to be worse in warm, dry, and windy weather. The most common sources of outdoor allergens include wind-pollenated plants such as grasses, trees, weeds and molds. The pollens from insect- pollinated plants are too heavy to remain airborne for long, and they are less likely to trigger an allergic reaction such as hay fever.
Description
Source
Molecular Weight
Product Code
A. alternate (Alt a 1)
E. coli
23kDa
R01753A
Timothy Grass (Phl p 1)
E. coli
33kDa
R01754A
Timothy Grass (Phl p 5a) E. coli
35kDa
R01755A
Timothy Grass (Phl p 5b) E. coli
33kDa
R01756A
Timothy Grass (Phl p 7)
E. coli
15kDa
R01757A
Timothy Grass (Phl p 12) E. coli
21kDa
R01758A
Plane Tree (Pla a 1)
P. pastoris
21kDa
R01759A
Plane Tree (Pla a 3)
E. coli
16kDa
R01760A
Mugwort (Art v 1)
P. pastoris
13kDa
R01761A
Mugwort (Art v 3)
E. coli
16kDa
R01762A
Life Science Division 5171 Wilfong Road, Memphis, TN 38134 901-382-8716 • 800-327-6299 • info@meridianlifescience.com
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06/19
www.MeridianLifeScience.com
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