Autoimmune Flyer

Autoimmune diseases are a broad range of related diseases in which a persons immune system produces an inappropriate response against its own cells, tissues and/or organs, resulting in inflammation and damage. AUTOIMMUNE PRODUCTS SUITED FOR THE DEVELOPMENT OF DIAGNOSTIC ASSAYS DETECTING LOCALIZED AND SYSTEMIC AUTOIMMUNE DISORDERS There are over 80 different autoimmune diseases, and these range from common to very rare diseases. Some autoimmune diseases affect mainly one part of the body (e.g. organ-specific such as multiple sclerosis which attacks the nervous system, autoimmune thyroid disease, and Crohn’s disease which is localized to the gastrointestinal tract) whilst others are systemic (such as systemic lupus erythematosus, rheumatoid arthritis and systemic vasculitis). Systemic autoimmune diseases can affect many body organs and tissues at the same time and they are broadly classified into rheumatological/connective tissue disease and vasculitis (inflammation of blood vessels). Autoimmune diseases collectively affect approximately 5%to 10%of the population of the developedworld. Common autoimmune diseases such as thyroiditis, rheumatoid arthritis and diabetes affect more than 1 in 100 people. In contrast, a rare autoimmune disease such as Goodpasture’s disease (a form of vasculitis) affects around 1 in amillion people. Autoimmune diseases disproportionately affect women at a rate of 2-9x greater than for men. Diagnostics

Autoimmune diseases are usually diagnosed using a combination of clinical history, blood tests (autoantibodies, inflammation, organ function) and other investigations such as x-rays. Specifically, autoantibodies act as biomarkers helping to diagnose disease subsets and monitor autoimmune diseases. Many autoantibodies have well-defined target antigens and can be detected with high analytical sensitivity for a particular disease.

Category

Disease

Tests

Includes rheumatoid arthritis, systemic lupus erythematosus (SLE), scleroderma, and other systemic autoimmune diseases. Inflammation in the blood vessels which can lead to serious consequences such as aneurysms. Blood clotting disorders, such as Antiphospholipid Syndrome (APS) which is a hypercoagulable state caused by antiphospholipid antibodies. Localized disorders that attack the gastrointestinal track such as Celiac Disease, Crohn’s Disease, UlcerativeColitis or Inflammatory Bowel Disease (IBS). Thyroid diseases (e.g. Hashimoto’s and Graves’ diseases), diabetes, adrenal fatigue, osteoporosis, infertility, polycystic ovary syndrome, and several others. Hashimoto’s and Graves’ disease are the most common autoimmune diseases.

• Anti-cytoplasmic antigens (c-ANCA) • Perinuclear antigens of neutrophils (p-ANCA)

Connective Tissue Disease

• Anti-cardiolipin • Anti-ß2 glycoprotein 1 • Anti-prothrombin (aPT)

Vasculitis

• Cardiolipin • ß2-gylcoprotein 1

Antiphospholipid

• Tissue transglutaminase (tTG) • Liver-kidney mircrosomal type 1 (LKM-1) • pANCA • Glutamic acid decarboxylase (GAD) • Tyrosine phosphatase-like islet cell antigen (IA2) • Thyroid peroxidase (TPO) • Thyroglobulin

Gastrointestinal

Endocrine

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RHEUMATOLOGY

GASTROENTEROLOGY CELIAC DISEASE Tissue Transglutaminase (tTG) A01363H Rec. Ag (HEK 293-EBNA Cell Line) >95% CHRONIC INFLAMMATORY BOWEL DISEASE Calprotectin A01671H Native Ag (Human neutrophils)

CONNECTIVE TISSUE DISEASE

Complement C1q A01670H

(Human Plasma) >95%

Sm/RNP AG A3C304B

K90020C C3 L01240G C4 L01241G L01243G

Sheep anti-Complement C1q

Native Ag (Calf Thymus)>90% Human anti-RNP Ag (Human Plasma)

K07102H

Goat anti-C3

Sm (Smith) Ag R01695

Goat anti-C4 Goat anti-C4

SmD2, Rec. Ag (Insect Cells) >85% Native Ag (Calf Thymus) >90%

A3C303B K07108H

U1-snRN C R01693 G01314M

Human anti-Sm Ag (Human Plasma)

Rec. Ag (Insect Cells) >85%

MAb

SS-A (Ro) Ag A3C300B

Native Ag (Calf Thymus) >90% Human anti-Ro (SS-A) Ag (Human Plasma) Rec. Ag (Insect Cells) >85% Native Ag (Calf Thymus) >95% Human anti-SS-B Ag (Human Plasma) Native Ag (Calf Thymus) >90% Human anti-Scl-70 Ag (Human Plasma) Native Ag (Calf Thymus) >90% Human anti-Jo-1 Ag (Human Plasma) P1, Rec. Ag (Insect Cells) >85% P2, Rec. Ag (Insect Cells) >85% Native Ag (Calf Thymus) >90% Human anti-Ribosomal P Ag (Human Plasma)

VASCULITIS Annexin A01682H

NEPHROLOGY

K07103H

Native Ag (Human neutrophils) Bacterial permeability increasing factor (BPI) A01678H Native Ag (Human neutrophils) >90% Cathepsin G A01679H Native Ag (Human neutrophils) Lactoferrin A01712H Native Ag (Human Milk) H01411M MAb to Lactoferrin (pair, LF assay) H01412M MAb to Lactoferrin (pair, LF assay) K99172C Rabbit anti-Human Lactoferrin Lysozyme A50178H Native Ag (Human neutrophils) >95%

SS-B (La) R01691 A3C022B K07104H Scl-70 A3C301B K07105H Jo-1 A3C302B K07101H

GOODPASTURE’S SYNDROME Glomerular Basement Membrane (GBM) A01672B Native Ag (Bovine Kidney) >90%

ENDOCRINOLOGY THYROID DISEASE Thyroid Peroxidase (TPO) A01309H Rec. Ag >95% Thyroglobulin (TG) H6T09-212 Recombinant Ag >96% A86852H Native Ag (Human Thyroid Tissue) >90%

Ribosomal P-proteins R01694

Myeloperoxidase (pANCA) A3C181H

R01692 A01676B K07107H dsDNA A01677E Ro52 R01649

Native Ag (Human neutrophils) >95% Rabbit anti-Myeloperoxidase

K50891R

Prothrombin A01681H

Native Ag (Human Plasma) >95%

Native Ag (E.coli) >90%

Proteinase 3 (cANCA) A3C192H

Native Ag (Human neutrophils) >90%

Rec. Ag (Sf21 Insect Cells) >90%

Proliferating Cell Nuclear Ag (PCNA) R01690 Rec. Ag (Insect Cells) >85% R01648

ANTI-PHOSPHOLIPID SYNDROME ß2-GLYCOPROTEIN-1 A3C083H

Rec. Ag (Sf21 Insect Cells) >90%

M1M20-912 MAb to PCNA MAM21-964 MAb to PCNA Histone A01673B

Native Ag (Human Plasma) >95%

Native Ag (Calf Thymus) >90%

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