Product list | Continued
Fatty Acid Binding Protein (FABP)
Galectin-3
Heart type FABP is a small cytoplasmic protein (15 kDa) released from cardiac myocytes following an ischemic episode. It is an early biomarker for myocardial infarction, detected in the blood within one to three hours of acute coronary syndrome. Antibody Pairs
Galectin-3 is a galactoside-binding protein G that binds to and activates myofibroblasts in damaged heart tissue, leading to collagen synthesis and subsequently problematic fibrosis. It has been correlated with the prognosis in patients with coronary heart failure and the first Galectin-3 biomarker assay was approved by the FDA in 2010. Monoclonals K01381M *Suitable for use in FC, produced in vivo K01382M *Suitable for use in FC, produced in cell culture
• Suitable for use in ELISA • MAbs produced in vivo CAPTURE H86505M H01314M H86101M H01314M H01315M H01324M H01323M H86101M
DETECTION
Ghrelin
* Also works in LF assays
Antigens A86865H
Clinical studies suggest a role for ghrelin in the treatment of CHF. Known cardiovascular effects of ghrelin include lowering of peripheral resistance either direct at the vascular level, and/or by modulating sympathetic nervous activity. Gherlin also has potential as a marker of abnormal metabolism in cardiac failure. Monoclonals • Suitable for use in ELISA • Produced in vivo E86621M Glycogen Phosphorylase Isoenzyme BB (GPBB) GPBB is an isoenzyme of glycogen phosphorylase and a key enzyme of glycogenolysis. It has been suggested as an early marker of acute myocardial infarction and unstable angina. Monoclonals • Suitable for use in ELISA and WB • Produced in vivo H86807M
• Native antigen from human heart • Suitable for use as a immunoassay standard, immunogen for antisera production, or a tracer for iodination • > 95% pure (10-20% gradient SDS-PAGE) • FABP3 Recombinant (E.coli) • Suitable for use in ELISA • 95% pure (silver staining SDS-PAGE)
R01617
Fibrinogen/ Fibrinopeptide A
Fibrinogen is a plasma glycoprotein that is essential for blood blotting and has the ability to promote thromboses, or clots, by causing platelets to clump inside blood vessels. A number of studies have shown elevated fibrinogen levels to be a major risk factor for coronary heart disease. Antibody Pairs • Suitable for use in ELISA
• For specific fibrinogen detection, pair a capture anti-fibrinopeptide A antibody with a detection anti-fibrinogen antibody • MAbs produced in vivo CAPTURE DETECTION N86710M N86413M * N86710M is specific for Fibrinopeptide A
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12 | Cardiac & Metabolic Markers for Assay Development Cardiac & Metabolic Markers for Assay Development
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