Product list | Continued
Malondialdehyde (MDA)
Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Lp-PLA2 is a protein produced by inflammatory cells that circulates mainly with LDL and is responsible for hydrolyzing oxidized phospholipids in LDL. It is highly upregulated in atherosclerotic plaques and is thought to be directly involved in the development of atherosclerosis and plaque rupture. Monoclonals
MDA is a reactive aldehyde produced by the degradation of polyunsaturated lipids and causes oxidative modification of LDL to form malondialdehyde low density lipoprotein (MDA- LDL). MDL-LDL is a sensitive biomarker for ACS patients with unstable angina and acute myocardial infarction. MDA-LDL not only serves as an oxidative stress marker but as a marker of plaque destabilization. Polyclonals CATALOG SOURCEFORMAT APPLICATION K97120P Goat HRP, Lyophilized EIA,WB
• Suitable for use in ELISA • Produced in cell culture H01389M Antibody Pairs • Suitable for use in ELISA • Produced in cell culture CAPTURE DETECTION H01390M H01393M H01390M H01389M H01392M H01393M Polyclonals CATALOG
Monocyte Chemotactic Protein 1 (MCP-1/MCAF)
Myeloperoxidase (MPO) MPO is a peroxidase enzyme and a marker of inflammation and neutrophil activation during strenuous exercise. In addition, it has been implicated in the oxidation of lipids contained in low-density lipoproteins, infiltration of macrophages and neutrophils, formation of unstable coronary plaques, and plaque rupture. MPO is elevated in patients with coronary artery disease and can serve as a prognostic marker to identify patients with unstable plaques before complete microvascular obstruction. Monoclonals • Suitable for use in ELISA • Produced in vivo (unless stated otherwise) H87207M *Also works in WB, IHC, FC and produced in cell culture K86005M *Also works in WB Specifically, high levels of MCP-1 have been associated with a poor prognosis and increased risk for death independent of other risk factors in patients with ACS. Antigens A01251H • Recombinant (E. coli) • Non-glycosylated polypeptide chain containing 76 a.a. • > 98% pure (RP-HPLC and SDS-PAGE), lyophilized MCP-1 is a cytokine produced by macrophages, smooth muscle cells and endothelial cells within atherosclerotic plaques and an important indicator of atherosclerotic plaque burden.
SOURCE FORMAT APPLICATION
H01333S Antigens A01413H
Sheep
Aff.Pur.
EIA,IHC,WB
• Recombinant (E. coli) • > 95% pure (SDS-PAGE) • Contains a His-tag
Low Density Lipoprotein Receptor-Related Protein (LRP) LRP is a large multifunctional receptor mediating the clearance of diverse ligands, including selected lipoproteins, various protease inhibitor complexes, and thrombospondin. The range of ligands recognized by LRP suggests that it plays a role in diverse processes including lipid metabolism, cell growth, migration, and tissue invasion. Monoclonals • Suitable for use in WB, IHC, and FC • Produced in vivo H63180M * Specifically reacts with the 515 kDa alpha-chain of human LRP/alpha2 H63080M * Specific for human light chain of LRP, 85 kDa
14
14 | Cardiac & Metabolic Markers for Assay Development Cardiac & Metabolic Markers for Assay Development
Powered by FlippingBook