Drug Testing Reagents for Commercial Assay Development

Drug Testing Reagents for Commercial Assay Development ANTIBODIES AND ANTIGENS DESIGNED FOR ASSAYS DETECTING THERAPEUTIC DRUGS AND DRUGS OF ABUSE

Immunoassays for drug-testing are generally divided into forensic (DOA assays) and clinical products (TDM serum assays). Due to the differences in applications there are distinct design, technical capabilities and regulatory approval processes for each type. Meridian offers a range of drug testing reagents designed to produce accurate and precise results for both qualitative and quantitative assays.

DRUG TESTING REAGENTS DRUGS OF ABUSE (DOA) Cannabinoids CNS stimulants Depressants Hallucinogens Opiates THERAPEUTIC MONITORING ANTIBIOTICS OTHER DRUG TESTING REAGENTS

Antibody & Conjugate Pairs MAbs suitable for rapid oral fluid or urine screening tests

ABOUT DRUG TESTING

Drug abuse testing traditionally refers to the practice of testing for drugs including depressants, hallucinogens, CNS stimulants, opiates, cannabinoids, and phencyclidine (PCP). These tests have expanded in recent years to include (1) workplace, military and school testing for drugs of abuse (DOA), (2) screening in sports for the use of performance enhancing compounds, and (3) the emergency-room in order to diagnose possible overdose situations. In all of these areas, the testing method is qualitative only and is typically dependent on a urine or saliva sample as the testing specimen. Specifically, these types of assays are designed to determine if an individual is or is not taking DOA or non-prescribed medications.

Another use of drug testing is to monitor drug pharmacokinetics in order to help physicians provide the best treatment to their patients. With most medications, a certain dosage level of the drug (the therapeutic range) is required to obtain the desired effect. The goal of therapeutic drug monitoring (TDM) is to optimize the dose and clinical outcome for each patient. Some key differences in the TDM testing method compared to DOA are (1) the diagnostic specimen is typically serum instead of urine, saliva or hair, (2) the results are quantitative and need to be accurate and precise over a large concentration range, and (3) the tests are designed for use in hospital laboratories as opposed to rapid point-of-care.

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ANTIBODY & DRUG CONJUGATE PAIRS

• All pairs are suitable for use in ELISA or Lateral Flow assays • Various conjugates available in different hapten: protein ratios

ANTIGEN CAPTURE

MAb DETECTION

ANTIGEN CAPTURE

MAb DETECTION

Y01301B (BSA) Y01287B (BSA) AMPHETAMINE

Y01280B (BGG) Y01298B (BSA) METHADONE

G01284M

G01280M

Saliva & Urine

G01282M or G01284M

G01301M or G01302M

BARBITAL

METHAMPHETAMINE

Y01272B (BSA) Y01285B (BSA)

G01272M

Saliva & Urine

Y01271B (BSA) Y01294B (BSA)

G01271M

Saliva & Urine

G01283M or G01285M

G01295M or G01296M or G01297M

BENZODIAZEPINE

Y01284B (BGG) Y01283B (BGG) Y01282B (BGG) Y01281B (BGG) Y01290B (BSA)

G01281M G01281M G01281M G01281M G01290M

Urine Saliva Saliva Urine

MORPHINE

Y01276B (BSA)

G01276M

Saliva & Urine

Y01295B (BSA 40:1) G01298M or G01299M or G01300M Y01296B (BSA 40:1) G01298M or G01299M or G01300M Y01297B (BSA 70:1) G01298M or G01299M or G01300M

BENZOYLECGONINE (MAIN COCAINE METABOLITE)

Y01293B (BSA)

G01294M or G01292M G01293M or G01292M

Y01292B (BSA)

BUPRENORPHINE

OPIUM

Y01291B (BSA)

G01291M

Y01275B (BSA)

G01275M

Saliva & Urine

COCAINE

Y01299B (BSA) OXYCODONE

Y01277B (BSA)

G01277M

Saliva & Urine

G01303M or G01304M

Saliva & Urine

EDDP

Y01306B (BSA) Y01305B (BGG)

G01306M G01306M

Saliva & Urine

Y01278B (BSA) PROPOXYPHENE

G01278M

Saliva & Urine

K2 (SYNTHETIC MARIJUANA)

THC

Y01302B (BSA)

G01305M

Saliva & Urine

Y01273B (BGG) Y01274B (BGG) Y01268B (BSA)

G01273M G01274M G01286M

Saliva & Urine Saliva & Urine

KETAMINE

Y01270B (BSA)

G01270M

Saliva & Urine

MDMA (ECSTACY)

G01267B (BSA)

G01265M

ILLICIT DRUGS

CANNABINOIDS

CNS STIMULANTS

G01299M (MAb) G01300M (MAb)

AMPHETAMINE G82988M (MAb) G01282M (MAb) G01284M (MAb) G01289M (MAb)

THC MAD12-066 (MAb) G01286M (MAb) G01238M (MAb) G82920M (MAb) G82922M (MAb) G01273M (MAb) G01274M (MAb)

Y01276B (BSA conj) Y01295B (BSA conj) Y01296B (BSA conj) Y01297B (BSA conj) OXYCODONE F82910R (PAb) G01303M (MAb) G01304M (MAb) Y01299B (BSA conj)

Y01287B (BSA conj) Y01301B (BSA conj) BUPRENORPHINE G01291M (MAb) Y01291B (BSA conj) Y01235B (BSA conj) BENZOYLECGONINE/ COCAINE G45020M (MAb) B G45132M (MAb)

Y01273B (BGG conj) Y01274B (BGG conj) Y01268B (BSA conj) PINACA (SYNTHETIC THC) Y01309B (BSA) K2 G01305M (MAb) Y01302B (BSA conj) UR-144 (SYNTHETIC THC) Y01308B (BSA conj)

HALLUCINOGENS

KETAMINE G01255M (MAb) G01269M (MAb) G01270M (MAb)

B+C B+C

HS

G82911M (MAb) G01277M (MAb) G01292M (MAb) G01293M (MAb)

Y01269B (BSA conj) Y01241B (BSA conj) Y01270B MDMA G01265M (MAb) G01266M (MAb) G01269M (MAb) G01267B (BSA conj) DEPRESSANTS BARBITAL G01283M (MAb) G01285M (MAb) G01272M (MAb) Y01272B (BSA conj) Y01285B (BSA conj) PHENOBARBITAL Y82611A (BSA conj) BENZODIAZEPINE G01290M (MAb) G01281M (MAb) Y01290B (BSA conj) Y01281B (BGG conj) Y01282B (BGG conj) Y01283B (BGG conj) Y01284B (BGG conj)

C

B+C B+C

(BSA conj) HS

G01294M (MAb) B Y01292B (BSA conj) B Y01293B (BSA conj) B Y01277B (BSA conj) C COTININE G01257M (MAb) Y01279B (BSA conj) COTININE-3 F82319R (PAb) COTININE-4 F82419R (PAb) F82451R (PAb) CAFFEINE G45110M (MAb) METHAMPHETAMINE

G01310M (MAb) G01311M (MAb) G01313M (MAb) G01314M (MAb)

OPIATES

METHADONE G01280M (MAb) G01301M (MAb) G01302M (MAb)

Y01280B (BGG conj) Y01298B (BSA conj) EDDP G01306M (MAb) Y01306B (BSA conj) Y01305B (BGG conj) OPIUM G01275M (MAb) Y01275B (BSA conj) PROPOXYPHENE G01278M (MAb) Y01278B (BSA conj) MORPHINE

G01271M (MAb) G35913M (MAb) G82913M (MAb) G01295M (MAb) G01296M (MAb) G01297M (MAb)

Y01294B (BSA conj) Y01271B (BSA conj)

G31263M (MAb) G01276M (MAb) G01298M (MAb)

HS - High Sensitivity | B - Benzoylecgonine | C - Cocaine

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THERAPEUTIC MONITORING

CARBAMAZEPINE G31234M (MAb) CYCLOSPORIN A G86313M (MAb) DIGOXIN MAD53-310C (MAb) MAD53-122 (MAb) G45135M (MAb) G45330M (MAb)

POLYETHYLENE GLYCOL (PEG)

THEOPHYLLINE MAD63-003 (MAb) TRICYCLIC ANTIDEPRESSANTS G01288M (MAb) Y01288B (BSA conj)

G01237M (MAb) G01236M (MAb) G01245B (MAb) TACROLIMUS (FK-506) G01239M (MAb)

ANTIBIOTICS

CHLORAMPHENICOL G01247M (MAb) G01248M (MAb) G01249M (MAb) G01250M (MAb) ENROFLOXACIN/CIPROFLOXACIN G55417M (MAb)

ERYTHROMYCIN G13012M GENTAMICIN G55102M (MAb) NEOMYCIN G13021M

PENICILLIN G13011M

(MAb BSA conj)

(MAb BSA conj)

STREPTOMYCIN G13013M TOBRAMYCIN MAD64-052 (MAb)

(MAb BSA conj)

(MAb BSA conj)

OTHER

DINITROPHENOL G01241M (MAb) G01235M (MAb) G01234M (MAb)

Life Science Division 5171 Wilfong Road, Memphis, TN 38134 901-382-8716 • 800-327-6299 • info@meridianlifescience.com

May 2018

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