Product list
Alpha 1 Antitrypsin (A1AT)
Abbreviations 6-His – Polyhistidine-tag Aff.Pur. – Affinity Purified, analyte-specific column Ag – Antigen Alk.Phos. – Alkaline Phosphatase conjugated product CLIA – Chemiluminescence Immunoassay CVD – Cardiovascular Disease DB – Dot Blot DFA – Direct Immunofluorescence Assay FC – Flow Cytometry FITC – Fluorescein conjugated product GST – Glutathione S-transferase HRP – Horseradish peroxidase conjugated product IB – Immunoblot
A1AT is a secretory glycoprotein mainly produced in the liver and monocytes. It is the most abundant serine protease inhibitor in human plasma. Several cancers are associated with A1AT deficiency including primary liver carcinoma, lung cancer, bladder cancer and malignant hepatoma. Monoclonals • Does not cross-react with alpha 1 antichymotrypsin H45200M
Alpha 2 Macroglobulin (A2M)
A2M functions as a universal protease inhibitor in serum and is capable of binding various cytokines and growth factors. Malignant tumors are able to synthesize and release proteins into the circulation, including A2M that protects the tumor against immune system attacks. A common variant of A2M has also been suggested to lead to an increased risk of Alzheimer’s disease. Polyclonals CATALOG SOURCE FORMAT APPLICATION L04330G Goat Monospecific IEP Antigens A50114H • Native antigen from human plasma • > 95% pure (SDS-PAGE), lyophilized
ICC – Immunocytochemistry IEP – Immunoelectrophoresis IFA – Immunofluorescence Assay
IgG – Immunoglobin G IgM – Immunoglobin M IHC – Immunohistochemistry IP – Immunoprecipitation LF – Lateral Flow Lysate – Cells which have been lysed MAb – Monoclonal antibody Monospecific – Single band when tested by immunoelectrophoresis Neat – Whole, unpurified, undiluted antisera Neph – Product has been quality controlled by Nephelometry PAb – Polyclonal antibody Purified/IgG – Refer to the Certificate of Analysis regarding the extent of purification and the purification process used. RIA – Radioimmunoassay RID – Radial Immunodiffusion SDS-PAGE – Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis TIA – Product has been quality controlled by Turbidimetry WB – Western blot
Alpha Fetoprotein (AFP)
AFP is a tumor marker used to help detect and diagnose cancers of the liver, testicles, and ovaries. AFP can be fractionated by affinity electrophoresis into 3 glycoforms: L1, L2, and L3. AFP-L3 is specific to malignant tumors. An AFP-L3 test is used to help evaluate the risk of developing hepatocellular carcinoma, especially in those with chronic liver disease, and also to evaluate response of hepatocellular carcinoma to treatment. Monoclonals • Does not cross-react with human serum albumin • Suitable for ELISA • MAbs produced in vivo (unless otherwise noted)
M01254M M01255M M86304B M86641M M86501M
* Also works in LF assays
* Biotin conjugated
* Reacts with AFP Receptor, suited to blocking AFP/ AFP-binding
4 | Cancer & Tumor Markers for Assay Development Cancer & Tumor Markers- Reagents for Assay Development 4
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