Meridian is a primary manufacturer of specialized high-quality molecular reagents and offers solutions to a wide range of industries to diagnose and treat diseases, discover new therapeutics or develop tests for environmental, food and cosmetic safety.
Cancer-causing Viruses
An estimated 12-20% of all human cancers are caused by seven known oncoviruses: • Epstein-Barr Virus (EBV) • Human Papillomavirus (HPV) • H epatitis B and C viruses (HBV and HCV) • H uman T-cell lymphotropic virus-1 (HTLV-1) • Human Herpesvirus-8 (HHV-8) • M erkel Cell Polyomavirus (MCPyV). HIV, which is not technically an oncovirus, can lead to cancer as infection with HIV renders a patient vulnerable to developing malignancies, especially those transmitted by oncogenic viruses. Infection with an oncovirus may cause cancer directly by dysregulating tumor suppressor genes and other oncogenes in the host, or indirectly, by way of chronic inflammation or immune suppression. Molecular and serological tests each present unique advantages in the detection of oncoviruses. While some are better detected through molecular assays, others exhibit superior performance with immunoassays. Meridian has both types of reagent solutions with a range of master mixes, enzymes, antigens and antibodies that offer superior performance with highly sensitive detection.
Molecular Solutions:
Meridian’s ready-to-use qPCR and RT-qPCR master mixes have been developed for fast cycling from inhibitor-rich clinical specimens such as blood, urine and saliva. A combination of the latest advances in buffer chemistry and PCR enhancers, in conjunction with an antibody or chemical-mediated DNA polymerase promote rapid, consistently accurate detection of the intended targets, even with multiplex qPCR assays. The mixes can be used as wet mixes or dried by lyophilization or air-drying, there are several advantages to this, including room temperature shipping and storage, extended shelf-life, and increased flexibility in the sample volume.
Urine Samples (e.g. HPV)
CAT NO.
PRODUCT
APPLICATION
Air-Dryable Direct DNA qPCR Urine Lyo-Ready Direct DNA qPCR Urine Lyo-Ready Direct DNA LAMP Urine
MDX150
qPCR
MDX152
qPCR
MDX154
LAMP
Blood Samples (HIV, HBV, HCV, HTLV-1)
CAT NO.
PRODUCT
APPLICATION
Air-Dryable Direct DNA qPCR Blood Air-Dryable Direct RNA/DNA qPCR Blood Lyo-Ready Direct DNA qPCR Blood Lyo-Ready Direct RNA/DNA qPCR Blood Lyo-Ready Direct DNA LAMP Blood Lyo-Ready Direct RNA/DNA LAMP Blood
MDX120
qPCR
MDX121
qPCR
MDX122
LAMP
MDX123
qPCR
MDX124
LAMP
MDX125
LAMP
Saliva Samples (HIV, HBV, HCV, HTLV-1)
CAT NO.
PRODUCT
APPLICATION
Air-Dryable Direct DNA qPCR Saliva Lyo-Ready Direct DNA qPCR Saliva Lyo-Ready Direct DNA LAMP Saliva
MDX130
qPCR
MDX132
qPCR
MDX134
LAMP
www.meridianbioscience.com/lifescience
HPV DNA Test:
Lyo-Ready Genotyping Direct qPCR Urine Mix, 4x (MDX158) Meridian’s Lyo-Ready Genotyping Direct qPCR Urine is a 4x inhibitor-resistant mix designed for highly specific and sensitive amplification for genotyping sequence variants, even in the presence of PCR inhibitors found in crude urine samples, to give exceptional cluster resolution with clear allele discrimination, even with challenging SNP targets. Furthermore, it can be used in a liquid or lyophilized format to create ambient-temperature stable assays, making it ideal for point-of-care (POC) devices.
Two high-risk strains of HPV cause more than 70% of cervical cancers 1 but can be treated if detected early enough. The World Health Organization recommends DNA-based genotyping testing for HPV as the primary screening method to identify women who have or are at risk of cervical pre-cancer. Typically the test screens for fourteen different HPV types, including HPV type 16 and HPV type 18.
Immunoassay Solutions:
Meridian’s expertise in virology, cell culture, protein expression, and protein purification has enabled the company to be a leader in infectious disease for the past 40 years. With more than 3,000 antigens and antibodies covering more than 325 infectious diseases, cancer biomarkers, cardiac and metabolic disorders, hormone imbalances, and autoimmune diseases, the company offers one of the largest portfolios of antigens and antibodies designed for commercial diagnostic assays.
HIV
TARGET CAT. NO PRODUCT NAME P24 BN1045 Mab to HIV-1 P24 P24 BN1046 Mab to HIV-1 P24 P24 BN1018
EBV
TARGET CAT. NO PRODUCT NAME EBV-VCA gp125 8202
Viral gp125 Rec. Antigen
EBV Lysate (P3H3)
EBV
R02100
HIV-1 P24, Rec. Antigen, Group M, Subtype B (JRCSF)
EBV Nuclear Antigen-1 (EBNA-1) Rec. Antigen
EBV EBN A-1
HIV-1 gp41, Rec. Antigen, Group O (Cameroon) HIV-1 gp41, Rec. Antigen, Group O (Cameroon) HIV-1 gp36, Rec. Antigen, Subtype A (ST) HIV-1 gp36, Rec. Antigen, Subtype A (ST)
gp41
BN1019
R01522
gp41
BN1023
HBV
TARGET CAT. NO PRODUCT NAME HBsAg BN1215 HBsAg (adr), Rec. Ag HBsAg VTI610 HBsAg, Rec. Ag. HBsAg BN1231 mAb to HBsAg HBsAg BN1219 mAb to HBsAg HBsAg BN1097 mAb to HBsAg HBsAg BN1098 mAb to HBsAg HBsAg BN1099 mAb to HBsAg HBsAg BN1100 mAb to HBsAg TARGET CAT. NO PRODUCT NAME Core BN1102 Mab to Hepatits C Core BN1101
gp36
BN1021
gp36 BN1025
HIV-1 gp36, Rec. Antigen, Subtype A (ST)
gp36 BN1026
HIV-1 gp36, Rec. Ag, Subtype A (ROD), N-term His-Tag
gp36 BN1027
HPV
TARGET CAT. NO PRODUCT NAME HPV18 R01429 HPV18 L1, Rec Ag. HPV18 MAV56-965 mAb to HPV18, E6 HPV18 MAV56-267 mAb to HPV18, E6 HPV16 R01428 HPV16 L1, Rec Ag HPV16 MAV56-981 mAb to HPV16, L1 HPV16 MAV56-271 mAb to HPV16, E2 HTLV-1 TARGET CAT. NO PRODUCT NAME p24 R18152 HTLV-1 p24, Rec Ag. Env. Ag. R18142 HTLV-1 Env. Ag, Rec Ag. gp46 R01434 HTLV-1 gp46, Rec Ag. gp21 R01433 HTLV-1 gp21, Rec Ag. References: 1. https://www.who.int/europe/news/item/11-09-2021-who-recommends-dna- testing-as-a-first-choice-screening-method-for-cervical-cancer-prevention
HCV
Mab to Hepatits C (TBD) HCV Chimeric, Rec. Ag, NS3+Capsid, N-term His-Tag HCV Capsid, Rec. Ag, Subtype 1a HCV Capsid, Rec. Ag, Subtype 1b
Core/NS3
BN1032
Core
BN1031
Core
BN1033
HCV NS4, Rec. Ag
NS4
BN1216
Core/NS3/ NS4/NS5
HCV NS3/Core/NS4/NS5 Rec. Ag
BN1250
Ordering information: USA 5171 Wilfong Road Memphis, Tennessee 38134 Phone: +1 901-382-8716 Fax: +1 901-333-8223
Email: info@meridianlifescience.com Orders: orders@meridianlifescience.com www.meridianbioscience.com/lifescience
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06/24
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