SARS-CoV-2 Recombinant Antigens

SARS-CoV-2 Genome Structure

SARS-CoV-2 Recombinant Antigens For COVID-19 Serology Testing

Spike (S1 & S2)

Membrane (M)

Nucleocapsid (N)

ssRNA (+ sense, ~30kb in length)

Envelope (E)

Serology testing is an important tool for monitoring the evolution of an outbreak and serology tests that detect neutralizing antibodies are particularly useful for evaluating vaccine-induced protective immunity. As new SARS-CoV-2 variants emerge with mutations in the spike S protein, their potential to become “escape mutants” and negatively impact vaccine efficacy needs to be evaluated through neutralization testing. Meridian’s panel of SARS-CoV-2 mutant recombinant antigens represent the World Heath Organization’s major variants of concern and are suitable for use in neutralization studies and as controls in serology assays. They complement the existing range of high-performing SAR-CoV-2 wild-type antigens, several of which are in current EUA approved COVID-19 IgG/IgM serology tests.

SARS-CoV-2 Recombinant Antigens

Wild-type SARS-CoV-2

Mutant SARS-CoV-2 Spike, S1 RBD

Trimeric Spike, S1 Protein (His-Tag) Represents amino acids 14 - 683 of SARS-CoV-2 plus the synthetic trimeric domain Spike Protein, S1 Subunit (His-Tag) Represents amino acids 14 - 683 of the SARS-CoV-2 S1 subunit Spike Protein, N-terminal Domain (NTD) S1 Subunit (His-Tag) Represents amino acids 16 - 305 of the SARS-CoV-2 N-terminal domain Spike Protein, S1 Subunit RBD (His-Tag) Represents amino acids 330 - 521 of the SARS-CoV-2 S1 subunit, RBD domain

L452R and T478K mutant (His-Tag) Represents B.1.617.2 (Delta Variant), a.a. 319 - 541



N501Y mutant (His-Tag) Represents B.1.1.7 strain, (Alpha variant) a.a. 319 - 541 K417N, E484K and N501Y mutant (His-Tag) Represents B.1.351 strain, (Beta variant) a.a. 319 - 541 K417T, E484K and N501Y mutant (His-Tag) Represents P.1 strain, (Gamma variant) a.a. 319 - 541







L452R mutant (His-Tag) Represents Epsilon variant, a.a. 319 - 541



Nucleocapsid Protein (His-Tag)

L452R and E484Q mutant (His-Tag) Represents B.1.167 strain (Kappa variant), a.a. 319-541



Spike Protein, S1 Subunit RBD (His-Tag)

Related products

All mutants work with MAb to SARS-CoV-2 Trimeric S1 (Cat#9550) as a control in neutralization assays.


Human ACE2 Protein (Fc1 Tag)

Insect-cell Expressed |

HEK293 Expressed

RBD = Receptor Binding Domain

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