Meridian Cancer Catalog CHINESE

用于开发肿瘤标志物 体外诊断试剂的原料 ISO认证

www.MeridianLifeScience.com

癌症诊断 癌症是世界范围内导致死亡的主要原因。每年超过一半的癌症死亡事件是由 肺癌、胃癌、肝癌、结肠直肠癌和女性乳腺癌引起的。如果近期癌症状况在 未来扩散到全球,那么癌症的负担在未来15年内将上升68%。癌症死亡率如 此之高的原因主要是疾病诊断延误以及国家间癌症筛查政策有差异。

早期检测是癌症诊断的关键,早期诊断可以提高 癌症治愈率和/或存活率。但是,管理和治疗癌症 的相关费用的经济负担也越来越重。无创技术如 血清免疫检测特异肿瘤标志物减少疾病筛查和监 测的相关费用是人们所热切追求的。这些标志物 能实现快速、经济和即时的癌症检测,并为医师 提供有价值的帮助以提高患者的生活质量。 癌症标志物 (也叫作肿瘤标志物)是肿瘤自身或 机体对癌症产生反应生成的蛋白质。它们可以分 为4组:(1)筛查和早期检测;(2)诊断确认; (3)治疗反应和预后预测;(4)监测疾病复 发。 在过去的十年间,对癌变和肿瘤进展理解的加深 揭示了大量的潜在肿瘤标志物。一些标志物仅仅 与一些类型的癌症有关,但是其他的可能与2种或 更多的癌症类型有关,“通用”的能检测一切癌 症的肿瘤标志物至今未被发现。

美国药监局批准的癌症生物标志物

甲状腺癌 (Tg)

乳腺癌 (CA15-3/MUC-1, CA27-29, CEA, erb.2/HER2/new) 胰腺癌 (CA19-9, CEA) 肝癌 (AFP) 结肠癌 (CEA) 卵巢癌(CA125, HE4) 前列腺癌 (PSA)

II | Cancer & Tumor Markers for Assay Development

产品快速查找清单

A α 1 酸性糖蛋白 (AGP)........................... 7 α1 抗胰凝乳蛋白酶 (ACT)..................... 7 α 1 抗胰蛋白酶 (A1AT).......................... 7 α 2 HS 糖蛋白 (AHSG)........................... 7 α2巨球蛋白(A2M)................................. 8 α甲胎蛋白 (AFP).................................... 8 淀粉酶..................................................... 8 载脂蛋白CI (Apo CI)............................ 9 载脂蛋白 E (Apo E). .............................. 9 B β 2 微球蛋白 (B2M). .............................. 9 C 钙粘素E................................................. 10 降钙素................................................... 10 钙网蛋白 L1.......................................... 10 癌症抗原 125 (CA125)........................ 10 癌症抗原 27.29 (CA27.29).................. 11 癌症抗原 15-3 (CA15-3 or MUC1)..... 11 癌症抗原 19-9 (CA19-9). .................... 11 癌症抗原 50 (CA50)............................ 12 癌症抗原CA72-4 (TAG-72)................ 12 癌症抗原 242 (CA242)........................ 12 癌胚抗原 (CEA). .................................. 12 过氧化氢酶........................................... 13 组织蛋白酶B......................................... 13 组织蛋白酶D....................................... 13 CD1d. .................................................. 13 CD3...................................................... 13 CD4...................................................... 13 CD8...................................................... 13 CD9...................................................... 13 CD13 (氨肽酶N)................................. 14 CD15.................................................... 14 CD19.................................................... 14 CD24.................................................... 14 CD28.................................................... 14 CD29 (整合蛋白beta-1)..................... 14 CD30.................................................... 14 CD37.................................................... 14 CD40.................................................... 15 CD42.................................................... 15 CD49d. ................................................ 15 CD49f (整合蛋白α -6)......................... 15 CD56 (神经细胞粘着分子或NCAM)...15 CD57 ................................................... 15 CD59.................................................... 15 CD66b. ................................................ 16 CD71.................................................... 16 CD77.................................................... 16 CD90.................................................... 16 CD103.................................................. 16 CD105 (内皮因子)............................... 16 CD147.................................................. 16 CD152 (CTLA-1).................................. 17 CD177.................................................. 17

CD195 (CCR5).................................... 17 着丝点蛋白B (CENPB)......................... 17 血浆铜蓝蛋白....................................... 17 c-Myc. ................................................. 17 IV型胶原蛋白. ...................................... 18 VI型胶原蛋白. ...................................... 18 细胞角蛋白 21-1, 细胞角蛋白19片段...18 D 防御素-beta......................................... 18 肌间线蛋白........................................... 18 桥粒胶蛋白3......................................... 19 素昂唾液栓神经节苷脂GD2............... 19 E 弹性蛋白酶........................................... 19 表皮生长因子 (EGFR).......................... 19 erbB-2, HER2/neu............................... 20 细胞粘附分子 (EpCAM) ..................... 20 F Factor H (Beta 1H). ............................ 20 Factor VIII (FVIII).................................. 20 酸性纤维母细胞生长因子 (FGF-acidic, FGF-1)............................ 20 纤连蛋白............................................... 21 G 甘油醛-3-磷酸脱氢酶 (GAPDH) ......... 21 蛋白多糖-1 (GPC1)............................. 21 H 热休克蛋白........................................... 21 血红蛋白............................................... 22 人附睾蛋白 4 (HE4).............................. 22 5-羟基甲基尿苷.................................... 22 I 胰岛素样生长因子I (IGF-I 或生长调节素C) ...................... 22 胰岛素样生长因子结合蛋白3(IGFBP-3) ..23 整合蛋白α M (CD11b/MAC-1). ........ 23 干扰素β(IFN-beta). ............................. 23 干扰素γ (IFN-gamma). ...................... 23 白介素1号α (IL-1a) 和 白介素1号受体(IL-1R) . ........................ 23 K 激肽释放酶........................................... 24 L 乳酸脱氢酶(LDH)................................. 24 核纤层蛋白........................................... 24 瘦蛋白................................................... 24 溶菌酶................................................... 25

M 微管关连蛋白2 (MAP-2)...................... 25 肥大细胞类胰蛋白酶 (MCT)................ 25 单核细胞趋化蛋白1 (MCP-1或CCL2)...25 N 中性粒细胞明胶酶相关脂质转运蛋白 (NGAL)/Lipocalin-2............................ 25 神经元特异性烯醇化酶(NSE) γ............ 26 非神经元烯醇化酶 (NNE 或 Alpha-enolase).................................. 26 O 骨桥蛋白 (OPN)................................... 26 P 胃蛋白酶原 I 和胃蛋白酶原 II (胃蛋白酶原C) . .................................. 26 PIVKA-II. ............................................... 27 催乳素 (PRL)......................................... 27 前列腺分泌蛋白 (PSP). ........................ 27 前列腺特异抗原 (PSA)......................... 27 前列腺特异性膜抗原 (PSMA).............. 28 前列腺酸性磷酸酶 (PAP)..................... 28 R 视黄醇结合蛋白 4 (RBP4).................... 29 S S-100..................................................... 29 混杂酶 1................................................ 29 血清淀粉样蛋白A (SAA). .................... 30 唾液酸化Lewis A和唾液酸化Lewis X..30 超氧化物歧化酶 (SOD)........................ 30 T 性腺活化调节因子 (TARC).................. 30 甲状腺过氧物酶 (TPO)......................... 31 甲状腺球蛋白 (Tg). .............................. 31 组织型转谷氨酰胺酶 (tTG).................. 31 胰蛋白酶............................................... 31 肿瘤坏死因子-α (TNF-alpha) ............. 32 U 尿激酶 (uPA)........................................ 32 V 玻连蛋白............................................... 32

III

www.MeridianLifeScience.com

=公司简介

迈迪安生命科学公司是家大规模生产以下产品的领军制造商: • 抗体

• PCR多聚酶 • 核苷酸 • 体外诊断关键试剂

• 病毒抗原 • 重组蛋白

40年以来,迈迪安生命科学公司始终坚持以提供创新的生命科学解决方案和建立值得信赖的合作伙 伴关系为我们的宗旨。我们的重点是为体外诊断试剂公司提供优质的原料和服务,使其有助于推动 这些领域的发展。

• 具 有蛋白质纯化的专业知识基础的各类抗原和抗体的商业化大规模生产 • 包 括各类抗原,抗体,及其封闭剂的完整的免疫学诊断试剂产品系列

• 大 规模生产的用于分子生物学检测的各种试剂 • 具 有开发体外诊断新技术经验的技术支持部门

• 具 有专门的研发团队和生产团队 • 具 有严格和成熟的质量管理体系

ISO Certified 13485:2016

用于开发肿瘤标志物体外诊断试剂的原料 - Reagents for Assay Development 1

全面的生产能力和服务

免疫学诊断 • 抗 原及抗体 • 重 组蛋白 • B 阻断剂

分子诊断 • 核 苷酸 • 酶 • 终 点PCR/定量PCR试剂 • 二 代测序 合同定制 • 抗 原及抗体 • 细 胞库及病毒库的建立 • P CR/qPCR检测研发 全球分布

迈迪安生物科学公司 母公司 | 成立于1977年 | 纳斯达克:VIVO 总部位于俄亥俄州辛辛那提 | 750+名员工 | 在70多个国家设有办事处

美国

欧洲

亚太平洋

澳大利亚,悉尼 销售和客户服务

田纳西州, 孟菲斯 病毒抗原 重组蛋白 I体外抗体 PCR 试剂

英国,伦敦 PCR / qPCR 试剂研发 PCR 试剂生产及销售 德国,卢肯瓦尔德 核苷酸大规模生产各类PCR 酶 法国,巴黎 EU 诊断销售和客户服务 比利时,滑铁卢 EU 诊断销售和客户服务 意大利,米兰 EU 诊断销售和客户服务

中国,北京 销售和分销 全资子公司

马萨诸塞州,比尔瑞卡 Magellan, Leadcare 佛罗里达州,博卡拉顿 体外抗体 魁北克,加拿大 GenePOC, 分子诊断

2

www.MeridianLifeScience.com

公司简介

• 3400+产品 •高度特异性&灵敏度 •抗体配对 •大批量

抗原和抗体

传染病 ToRCH • Toxo • Rubella • CMV • HSV-1, 2

童年 • Mumps • Rubeola • EBV

热带 • Nipah • Dengue 1, 2, 3, 4

• Coxsackie • Rotavirus • RSV • Parvo B19 • VZV

• Chikungunya • Mayaro Virus • Malaria • Chagas • Lassa Virus

胃肠道 • Norovirus • Astrovirus • Adenovirus • Rotavirus •  Clostridium difficile •  Cryptosporidium •  Campylobacter •  E. coli •  Salmonella •  Giardia Iamblia

食物和水 • Hepatitis A •  Campylobacter jejuni •  E. coli •  Legionella pneumophila •  Salmonella •  Shigella •  Bacillus anthracis •  Clostridium •  Listeria •  Streptococcus •  Staphylococcus •  Giardia lamblia •  Cryptosporidium

呼吸 • RSV

• Leishmaniasis • Leptospirosis • Newcastle disease • Yellow Fever • Zika • Lyme disease • Ebola

• Influenza A,B • Parainfluenza •  Mycoplasma pneumoniae •  Chlamydia pneumoniae •  Legionella pneumophila •  Mycobacterium tuberculosis •  Streptococcus •  Staphylococcus • SARS Coronavirus • Adenovirus

性病 • HSV-1, 2 • HIV-1, 2 • HPV • Chlamydia • Neisseria • Syphilis

•  H. pylori Hepatitis

• HAV • HBV • HCV • HEV

用于开发肿瘤标志物体外诊断试剂的原料 - Reagents for Assay Development 3

癌症

心脏的

• PIVKA-II • CA125 • CA15-3 • CA19-9 • CA72-4 • CA50 • CA242 • CEA • Cyfra 21-1 • erbB-2/HER2 • AFP

• EGFR • HE4 • NSE • P53 • PMA

• Troponin I, T • Myoglobin • BNP • NT-proBNP • CRP • PCT • CK-MB • Apo A,B,E • NSE • FABP • SAH • Galectin-3

• Cystatin-C • D-Dimer • MPO • Fibrinogen • EGF • sCD40L • CD54 • Lp-PLA2 • PAPP-A • Vitamin D • Renin

• PAP • PSA

• PSMA • S-100 • B2M • Thyroglobulin

免疫球蛋白/阻滞剂

激素

• TRU Block™ & IgM Diluent • Animal IgGs – Bovine, Chicken, Goat, Mouse, Rabbit, Sheep • Human IgA, IgG, IgM, IgE

• LH, FSH, hCG, hGH • AMH • Cortisol, Estradiol • Insulin, C-peptide • Prolactin • Progesterone • PTH

• PAPP-A • TSH, T4, T3, ACTH • Thyroglobulin

• Kappa Light chain • Lambda Light chain • Goat Anti-Human IgG, IgM, IgA • Goat Anti-Mouse IgG

滥用药物

• Amphetamine • Barbital • Benzodiazepine • Buprenorphine

• Fentanyl • Ketamine • K2 • MDMA (Ecstasy) • Methadone • Methamphetamine • Morphine

• Norketamine • Opium • Oxycodone • PCP • Phenobarbital • Propoxyphene • THC

• Cocaine • Cotinine • EDDP 自身免疫性 • Jo-1 • PCNA

过敏原 • Animal • Dust Mite • Mold • Pollen

• Histone • GMB • C1q • ScI-70 • B2-Gly-1

• pANCA • cANCA • Sm Ag • dsDNA

• Cathepsin G • Calprotectin

• La (SS-B) • Ro (SS-A)

4

www.MeridianLifeScience.com

推荐产品

抗体和配对

Alpha Fetoprotein (AFP) M86304M

Epidermal Growth Factor Receptor 2 (ERB2, HER2/NEU) M01296M

MAb (Capture) , ELISA MAb (Detection) , ELISA

M86641M

MAb, ELISA, reacts with peptide ILDV4 (dephosphorylated) MAb, ELISA, reacts with peptide ILDV4 (phosphorylated) MAb, ELISA, reacts with peptide ILDV2 (dephosphorylated) MAb, ELISA, reacts with peptide ILDV2 (phosphorylated)

* Not cross reactive with human albumin. MAM01-210 MAb (Capture) , ELISA MAM01-301 MAb (Detection) , ELISA

M01297M

M01298M

Beta 2 Microglobulin (B2M) MCP17-301 MAb, ELISA & RIA * Reacts with soluble B2M and B2M associated with cell-surface MHC Class I molecules and other membrane antigens. CA15-3 M86240M MAb (Capture) , ELISA M01288M MAb (Detection) , ELISA * Epitope is located within the VNTR tandem repeat region of MUC1 CA125 M86306M MAb Group A (Capture) , ELISA & WB M86924M MAb Group B (Detection) , ELISA & WB M86306M MAb Group A (Capture) , ELISA & WB M86429M MAb Group B (Detection) , ELISA & WB * Both pairs detect OC125 (Group A) and M11 (Group B). CA19-9 M66107M MAb (Capture) , ELISA M66106M MAb (Detection) , ELISA M66108M MAb (Alternate Detection) , ELISA M66106M MAb (Capture/Detection) , ELISA M66108M MAb (Capture/Detection) , ELISA * Abs can be used as capture or detection in a sandwich assay. M01335M MAb, ELISA CA72-4 M01341M MAb (Capture) , ELISA M01342M MAb (Alternate Capture) , ELISA M01340M MAb (Detection) , ELISA CEA

M01299M

HE4 M01323M M01320M M01323M M01321M

MAb (Capture) , ELISA MAb (Detection) , ELISA

MAb (Capture) , ELISA

MAb (Detection) , ELISA Human Hemoglobin (Fecal Occult Blood) H01348M MAb (Capture) , ELISA H01349M MAb (Detection) , ELISA H01416M MAb (Capture) , ELISA H01369M MAb (Detection) , ELISA H01409M MAb (Capture) , LF & Turbidimetry H01410M MAb (Detection) , LF & Turbidimetry Neuron Specific Enolase (NSE) M86101M MAb (Capture/Detection) , ELISA M86520M MAb (Capture/Detection) , ELISA * Abs can be used as capture or detection in a sandwich assay. Pepsinogen I K01402M MAb (Capture) , ELISA & LF K01403M MAb (Detection) , ELISA & LF K01406M MAb (Capture) , ELISA & LF K01407M MAb (Detection) , ELISA & LF Pepsinogen II K01404M MAb (Capture) , ELISA & LF K01405M MAb (Detection) , ELISA & LF

MAM02-008 MAb (Capture/Detection) , ELISA MAM02-009 MAb (Capture/Detection) , ELISA * Abs can be used as capture or detection in a sandwich assay.

PIVKA-II M01344M M01343M

MAb (Capture) , ELISA

MAM02-009 MAb (Capture) , ELISA MAM02-881 MAb (Detection) , ELISA M01250M

MAb (Detection) , ELISA Prostate Specific Antigen (PSA) Free M92986M MAb (Capture) , ELISA M92396M MAb (Detection) , ELISA * Not cross reactive to Albumin, AFP, CEA, PAP, CA125, CA19-9 or CA15-3. M86506M MAb (Capture/Detection) , ELISA & LF M86806M MAb (Capture/Detection) , ELISA & LF

MAb (Capture) , ELISA & IHC MAb (Detection) , ELISA & IHC

M01246M

* Specific for CEA epitope specificity group I.

Cyfra 21-1 (Cytokeratin 19) M01300M MAb, ELISA & WB M01326M MAb, ELISA

5 | Cancer & Tumor Markers for Assay Development 用于开发肿瘤标志物体外诊断试剂的原料 - Reagents for Assay Development 5

Prostate Specific Antigen (PSA) Total M66276M MAb (Capture) , ELISA & LF M86506M MAb (Detection) , ELISA & LF * Specific for epitope 5 and not cross reactive with human kallikrein 2. M01236M MAb (Capture) , ELISA & LF M86506M MAb (Detection) , ELISA & LF Prostate Specific Membrane Antigen (PSMA) M20454M MAb, ELISA & IFA * Specific to the extracellular domain of PSMA.

S-100 Beta Q86006M

MAb (Capture) , ELISA MAb (Detection) , ELISA MAb (Capture) , ELISA

Q86610M Q86003M

Q86610M MAb (Detection) , ELISA * Each capture is specific for alpha-beta and each detection for alpha-beta and beta-beta. Thyroglobulin E01326M MAb (Capture) , ELISA E01325M MAb (Detection) , ELISA * Does not interfere with anti-thyroglobulin auto-antibodies.

人体抗原 (用作标准品、质控品和校准品)

Alpha Fetoprotein (AFP) A32260H

Neuron Specific Enolase (NSE) A86803H

Produced in cell culture, derived from a liver tumor cell and contains approximately 70% of the AFP-L3 isoform, ≥ 95% pure (SDS-PAGE & WB)

From human brain, > 95% pure (SDS-PAGE)

Pepsinogen II A01691H

Purified from human stomach, lyophilized, ≥ 90% pure (SDS-PAGE)

Beta 2 Microglobulin (B2M) A01412H

Pepsinogen II A01420H

From human urine, ≥ 98% pure (SDS-PAGE)

From human gastric mucosa, > 90% pure (SDS-PAGE) Purified from human stomach, lyophilized, ≥ 90% pure (SDS-PAGE) PSA, from human seminal fluid, lyophilized, > 95% pure (SDS-PAGE) PSA/ACT Complex, from human seminal fluid and plasma, > 95% pure (SDS-PAGE) PSA, From human seminal fluid, lyophilized, > 98% pure (SDS-PAGE)

CA15-3 A32231H CA125 A32180H CA19-9 A86199H A01458H CA72-4 A01723H CA50 A01264H CEA A32030H A38151H

Produced in cell culture, low cross reactivity

A01692H

Prostate Specific Antigen (PSA) A01368H

Produced in cell culture, low cross reactivity

From native human metastatic liver carcinoma Produced in cell culture, provided as cell culture concentrate

A31029H

A86878H

Produced in cell culture, low cross reactivity

Prostatic Acid Phosphatase (PAP) A01277H

From human seminal fluid, lyophilized > 96% pure

Produced in cell culture, provided as cell culture concentrate

S-100 Beta A86809H

From human brain tissue, contains both beta-beta and alpha-beta isoforms, > 95% pure From human brain tissue, contains only beta-beta homodimer, > 95% pure (SDS-PAGE)

A86289H

Produced in cell culture, > 50% pure (SDS-PAGE)

From native human liver metastases, > 95% pure (SDS-PAGE)

Thyroglobulin H6T08-747

Cyfra 21-1 A32340H

From human thyroid tissue, > 98% pure (SDS-PSGE) From human thyroid tissue, > 90% pure (SDS-PAGE)

Produced in cell culture, low cross reactivity

A86852H

Human Hemoglobin (Fecal Occult Blood) A38192H From human erythrocytes, > 96% pure (SDS-PAGE)

6

www.MeridianLifeScience.com | 6 w .Merid anLifeScience.com

产品列表

α 1 酸性糖蛋白 (AGP)

缩略语表

AGP是一种主要的急性期蛋白(一类对炎症产生反应血浆浓度升 高或降低的蛋白)。AGP蛋白水平的变化已经被列为肺癌和乳腺 癌的生理和病理条件。 抗原 A50106H • Native antigen from human plasma • > 95% pure (SDS-PAGE), lyophilized

6-His – Polyhistidine-tag Aff.Pur. – Affinity Purified, analyte-specific column Ag – Antigen Alk.Phos. – Alkaline Phosphatase conjugated product CLIA – Chemiluminescence Immunoassay CVD – Cardiovascular Disease DB – Dot Blot DFA – Direct Immunofluorescence Assay FC – Flow Cytometry FITC – Fluorescein conjugated product GST – Glutathione S-transferase HRP – Horseradish peroxidase conjugated product IB – Immunoblot

α1 抗胰凝乳蛋白酶 (ACT)

.ACT在血浆内主要以前列腺特异抗原(PSA)复合物的形式存 在。测量游离PSA和PSA-ACT复合物能通过区分前列腺和非恶心 前列腺疾病如前列腺肥大改善血清PSA试验的性能。 抗原 A50104H • Native antigen from human plasma • 95% pure (SDS-PAGE), lyophilized

ICC – Immunocytochemistry IEP – Immunoelectrophoresis IFA – Immunofluorescence Assay

α 1 抗胰蛋白酶 (A1AT)

A1AT是一种主要在肝脏和乳房内生成的分泌糖蛋白。它是人血 浆内最丰富的的丝氨酸蛋白酶抑制剂。一些癌症与A1AT的减少 有关,如早期肝癌、肺癌膀胱癌和恶性肝癌。 单抗 • Does not cross-react with alpha 1 antichymotrypsin H45200M 抗原 A50110H • Native antigen from human plasma • > 95% pure (SDS-PAGE), lyophilized

IgG – Immunoglobin G IgM – Immunoglobin M IHC – Immunohistochemistry IP – Immunoprecipitation LF – Lateral Flow Lysate – Cells which have been lysed MAb – Monoclonal antibody Monospecific – Single band when tested by immunoelectrophoresis Neat – Whole, unpurified, undiluted antisera Neph – Product has been quality controlled by Nephelometry PAb – Polyclonal antibody Purified/IgG – Refer to the Certificate of Analysis regarding the extent of purification and the purification process used. RIA – Radioimmunoassay RID – Radial Immunodiffusion SDS-PAGE – Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis TIA – Product has been quality controlled by Turbidimetry WB – Western blot

α 2 HS 糖蛋白 (AHSG)

AHSG是一种血清内的糖蛋白,由肝细胞形成。AHSG和抗AHSG 自身抗体可以用作乳腺癌筛查和诊断的血清标志物。 抗原 A50107H • Native antigen from human plasma • > 90% pure (SDS-PAGE), lyophilized

7 | Cancer & Tumor Markers for Assay Development 用于开发肿瘤标志物体外诊断试剂的原料 - Reagents for Assay Development 7

多抗 CATALOG K92204R 抗原 A01441H

α2巨球蛋白(A2M)

SOURCE FORMAT APPLICATION

A2M是血清内的通用蛋白酶抑制剂,能够结合多种细胞因子和 生长因子。恶性肿瘤能够形成并释放蛋白质到循环中,包括 A2M能保护肿瘤免受免疫系统攻击。A2M的一个常见变体也被 认为是阿兹海默并风险增加的因素。 多抗 CATALOG SOURCE FORMAT APPLICATION L04330G Goat Monospecific IEP 抗原 A50114H • Native antigen from human plasma • > 95% pure (SDS-PAGE), lyophilized

Rabbit

Purified

ELISA

• Native antigen from human cord blood • Suitable for use in ELISA • 98% Pure • Native antigen from human cord serum • Suitable for use in ELISA and WB • > 99% pure (SDS-PAGE) • Native antigen from human cord serum • Suitable for use in ELISA and WB • > 99% pure (SDS-PAGE), lyophilized • N ative antigen from human hepatocellular carcinoma cell line • C ontains approximately 70% of the AFP-L3 isoform • 95% pure (SDS-PAGE) • Suitable for use in ELISA and WB

A01406H

A01407H

α甲胎蛋白 (AFP)

A32260H

AFP是有助于检测和诊断肝癌、睾丸癌和卵巢癌的肿瘤标志 物。AFP可以亲和电泳分为3种糖链异质体:L1、L2和L3。AFP-L3 针对恶性肿瘤。AFP-L3试验有助于评估发展中的肝细胞肝癌的风 险,尤其对于那些慢性干病患者,还能评估肝细胞肝癌对治疗的 反应。 单抗 • Does not cross-react with human serum albumin • Suitable for ELISA • MAbs produced in vivo (unless otherwise noted)

淀粉酶 淀粉酶是一种由胰腺外和唾液腺分泌的酶,有助于硝化淀粉。淀 粉酶的酶水平可能会在胰腺、唾液腺、前列腺、肺部和卵巢肿瘤 发生时升高。一般来说,血液淀粉酶试验有助于急性胰腺炎的诊 断和监测。 多抗 CATALOG SOURCE FORMAT APPLICATION K50894R Rabbit Purified IEP,WB 抗原 A38120H • Native alpha amylase from human pancreas • S pecific activity of 450 Units/mg protein (lot dependent) • Purified and lyophilized

M01254M M01255M M86304B M86641M M86501M

* Also works in LF assays

* Biotin conjugated

* Reacts with AFP Receptor, suited to blocking AFP/ AFP-binding

抗体配对 • Suitable for ELISA • MAbs produced in vivo (unless otherwise noted) CAPTURE DETECTION H45610M H45301M

* Does not react with human albumin, ferritin, hCG or PSA

A38211H

• Native alpha amylase from human saliva • S pecific activity of 620 Units/mg protein (lot dependent) • > 90% pure (SDS-PAGE), lyophilized • Native alpha amylase from pig pancreas • S pecific activity of 640 Units/mg protein (lot dependent) • Purified and lyophilized

MAM01-210 MAM01-301 MAM01-301 K92270G M86304M M86641M

* K92270G is a polyclonal (goat) * Does not react with human albumin

A01389P

8

www.MeridianLifeScience.com | 8 w .Merid anLifeScience.com

产品列表续

β 2 微球蛋白 (B2M)

载脂蛋白 CI (Apo CI)

B2M是一种包括在MHCI类微粒,并发现于几乎所有有核细胞表 面的蛋白。BM2水平升高先于淋巴增生性障碍、肿瘤(恶性和 早期)、炎症疾病以及自身免疫疾病如全身性红斑狼疮和格伦 病。对于癌症而言,它不能用于特定类型癌症的诊断,但是它与 癌症的出现有关,可用作一些血细胞癌症的预后肿瘤标志物。 单抗 • Recognizes the HLA-B2M complex, free or associated with the membrane • Suitable for use in FC, IHC and IFA • Lyophilized H42114M • Reacts with soluble forms of B2M and B2M associated with cell-surface MHC Class I molecules and other membrane antigens • Suitable for use in ELISA, WB, FC, IP, and RIA MCP17-301 多抗 CATALOG SOURCE FORMAT APPLICATION H01377G Goat Purified IEP K01372G Goat Aff.Pur. N/A K31640S Sheep Aff.Pur. N/A 抗原 A01447H • Native antigen from human urine

Apo CI是载脂蛋白家族最小的成员,主要分布于极低密度脂蛋 白乳糜和高密度脂蛋白表面。它是结肠直肠癌、前列腺癌、乳 腺癌、肺癌、甲状腺癌、恶性胸膜间皮瘤、胃癌、胰腺癌和肾 母细胞瘤的潜在血清标志物。 多抗 CATALOG SOURCE FORMAT APPLICATION K74110R Rabbit Aff.Pur. ELISA,IB 抗原 A50366H • Native antigen from human plasma VLDL • 95% pure (SDS-PAGE)

载脂蛋白 E (Apo E)

ApoE是乳糜微滴和中密度脂蛋白中发现的一类载脂蛋白。 它与心血管疾病、阿兹海默病、痴呆、动脉粥样硬化、多发 性硬化、外周动脉疾病、糖尿病、中风和大多数癌症包括乳 腺和卵巢癌有关。 单抗 • Reacts to the E2, E3 and E4 isoforms of apolipoprotein E • Produced in vivo • Suitable for ELISA, IHC, IP and WB H06579M • Reacts with VLDL of human plasma • Suitable for use in ELISA and IHC • Produced in vivo , lyophilized H61529M 多抗 CATALOG SOURCE FORMAT APPLICATION G5C27-766 Goat Aff.Pur. N/A K34002G Goat HRP ELISA,WB K74190G Goat Aff.Pur. ELISA,WB K62710G Goat Monospecific IEP,TIA K74180B Goat Biotin ELISA,WB H01378G Goat Purified IEP 抗原 A50120H • Native antigen from human plasma (VLDL) • > 95% pure (SDS-PAGE)

• Suitable for use in ELISA • 98% Purity (SDS-PAGE)

A01410H

• Native antigen from human urine • > 98% Purity (SDS-PAGE), lyophilized • Native antigen from human urine • 98% Purity (SDS-PAGE) • Recombinant (E.coli) • 95% Pure (HPLC), lyophilized

A01412H

A01468H

9 | Cancer & Tumor Markers for Assay Development Cancer & Tumor Markers - Reagents for Assay Development 9

钙粘素E 钙粘素 E是一种依靠细胞粘附分子的钙,主要在上皮组织内表 达。它在细胞生长和增殖以及组织构建机制以及组织完整性维护 中发挥重要作用。测定该物质对肿瘤进展很重要,它可以作为肿 瘤侵袭和代谢的抑制剂(失去钙粘素E功能将促进肿瘤恶化)。 单抗 • Recognizes Cadherin-E expressed on non-neuronal epithelial cells

癌症抗原 125 (CA125) 它是一种人体内的蛋白,被MUC16基因编码并发现于多种卵巢 癌细胞的表面。检测CA125血清水平有助于测定卵巢癌对疗法的 反应程度,预测患者的治疗预后。 抗体配对 • Detects both Group A and Group B • Suitable for use in ELISA and WB • MAbs produced in in vivo CAPTURE DETECTION

• Suitable for use in IHC and IP • Produced in vivo , lyophilized P91176M

M86306M M86924M M86306M M86429M 单抗 • Suitable for use in ELISA and WB • MAbs produced in vivo M86306B

降钙素 降钙素是由甲状腺的C细胞产生的多肽激素,其作用是降低血钙 (Ca2 +),降低甲状旁腺激素(PTH)的作用。降钙素测定法 用于鉴别结节性甲状腺疾病患者并诊断甲状腺髓样癌 Antibody Pairs

* Specific to Group A, biotin conjugated * Specific to Group B, biotin conjugated

M86429B

抗原 A01693H

• Suitable for use in CLIA, ELISA and RIA • Recognizes Native Human Calcitonin CAPTURE DETECTION E01357M E01356M

• O varian Cancer, Calibrator Grade • L ow cross-reactivity • S uitable for use as a calibrator for single or multiple analyte controls • Low cross-reactivity ideal for multi-analyte panels • Cell culture derived protein • C ell culture derived protein from ovarian carcinoma cell line • Suitable for use in WB and RIA • C ell culture derived protein from human adenocarcinoma cell line • Suitable for use as a calibrator • Native antigen from human fluids • Suitable for use as a calibrator • Low cross-reactivity • C ell culture derived protein from human adenocarcinoma cell line • Suitable for use as a calibrator • > 50% pure (SDS-PAGE) • Partially pure antigen from human fluids • Low cross-reactivity • S uitable for use in ELISA and Electrochemiluminescence assay as a calibrator or control

A32180H

钙网蛋白 L1 钙网蛋白L1是一种中性粒细胞衍生的蛋白质,可以在粪便内定 量,已经成为全肠道炎症的标志物。粪钙网蛋白水平与结肠直 肠癌生活方式风险因素有关。 抗体配对

A97180H

A86125H

• Suitable for use in ELISA with stool samples • MAbs produced in cell culture, lyophilized CAPTURE DETECTION K01373M K01376M 单抗 • Suitable for use in ELISA • Produced in cell culture, lyophilized

A43350H

A86928H

K01374M K01375M

A01690H

Please note that cell culture derived antigens offer several advantages over the native fluid versions, including greater availability of the product.

10

www.MeridianLifeScience.com | 10 .M ridia if ie .c

产品列表续

A32000H

• S uitable for use in CLIA and WB • C ell culture derived protein from human BTA cell line • N ative antigen from human fluids • H igh purity (relative Purity Ratio: > 20,000 Units/mL/OD280nm) • Suitable for use in ELISA and WB

癌症抗原 27.29 (CA27.29)

该物质是MUC1粘糖蛋白核心的表位,和CA15-3的表位在分子层 面类似。该物质水平升高与转移性乳腺癌有关,目前用作晚期乳 腺癌的治疗监测生物标志物。 单抗 • Recognizes both cell culture and human fluid derived antigens • The minimal epitope bound is the 8 amino acid sequence SAPDTRPA within the 20 amino acid tandem

A01436H

Please note that cell culture derived antigens offer several advantages over the native fluid versions, including greater availability of the product.

repeating sequence of the mucin core • Suitable for use in ELISA, WB and IHC • Produced in cell culture M01334M

癌症抗原 19-9 (CA19-9) 也称为唾液酸化刘易斯抗原,CA19-9是一种主要用于胰腺癌管 理的标志物。它在一些类型的胃肠癌症如结肠直肠癌、食道癌和 肝细胞肝癌中也会升高。除了癌症,胰腺炎、肝硬化和胆管病发 生时它的水平也会升高。 单抗 • Suitable for IHC • Produced in in vivo M01237M 抗体配对 • Suitable for use in ELISA • MAbs produced in vivo (unless otherwise noted) CAPTURE DETECTION

癌症抗原 15-3 (CA15-3 or MUC1)

CA15-3细胞外部分的免疫显性表位膜结合粘蛋白MUC1的肿瘤 标志物。它用于监测患者对乳腺癌治疗的反应及肿瘤复 发。CA15-3和相关的CA27.29是相同的基因产物的不同表位。 抗体配对 • Binds to an epitope within the VNTR tandem repeat peptide region of MUC1 • Suitable for use in ELISA and IHC • MAbs produced in in vivo CAPTURE DETECTION SPECIFIC FOR CA15-3 M86240M M01288M * Underglycosylated M86240M M01289M * Underglycosylated M86240M M86240M * Unglycosylated 抗原 A32231H • L ow cross-reactivity ideal for multi-analyte panels • Suitable for use as a calibrator or control • Suitable for use in CLIA • C ell culture derived protein from human BTA cell line A86153H • Native antigen from human milk

M66106M M66108M M66107M M66106M M66107M M66108M M66108M M66106M M01335M M01335M

* Pair does not cross-react CA72-4, PSA, CA125, CA242, and CEA

* Produced in cell culture, also works in IHC and WB

抗原 A32502H

• C ell culture derived protein from human adenocarcinoma cell line • Suitable for use in CLIA • N ative antigen from metastatic liver carcinoma • S uitable for use as a calibrator and an immunogen for antibody development • Cell culture derived protein • Concentrated (~76,000 U/mL), lot

A86199H

• S uitable for use as a calibrator or as an immunogen for antibody development

A01458H

dependent Please note that cell culture derived antigens offer several advantages over the native fluid versions, including greater availability of the product.

11

11 | Cancer & Tumor Markers for Assay Development

Cancer & Tu or Markers - Reagents for Assay Development

癌症抗原 50 (CA50)

癌胚抗原 (CEA) CEA是一种胚胎发育期间胃肠道细胞产生的糖蛋白分子,CEA 在血液内的水平通常很低。特定类型的癌症可以检出升高的 CEA水平,目前CEA使用途最广的肿瘤标志物,用于评估预 后,检测复发和监测直肠结肠癌患者的治疗。胰腺癌、胃癌、乳 腺癌、肺癌、甲状腺髓样癌和卵巢癌也会检出高水平的CEA。 单抗 • Suitable for use in enzyme conjugation, radio-labeling or solid phase immobilization • Produced in vivo H45655M • Suitable for use in FC • Specific for epitope group V

CA50癌症抗原是一种糖脂,肝硬化和胰腺疾病会出现CA50水 平升高。CA50在胃肠癌中出现最为普遍,但是与消化道外癌症 有关。 抗原 A01264H • Cell culture derived protein Please note that cell culture derived antigens offer several advantages over the native fluid versions, including greater availability of the product.

癌症抗原 CA72-4 (TAG-72)

CA72-4是一种粘糖蛋白,用作胃癌和卵巢癌的肿瘤标志物(临 床研究证明诊断特异性超过95%)。血清和血浆升高的CA72-4 水平已经在诸多癌症如胰腺癌、胃癌、胆囊癌、子宫颈和子宫内 膜癌变中的报告中出现。血清学CA72-4水平与肿瘤阶段和大小 有良好的相关性。它已经被卵巢癌患者的疗法监测和随访护理用 作独立的标志物,尤其是那些CA125呈阴性的患者。 抗体配对

M01329M 抗体配对

• Suitable for use in ELISA • MAbs produced in vivo CAPTURE DETECTION MAM02-008 MAM02-009 MAM02-009 MAM02-007 MAM02-009 MAM02-008 MAM02-009 MAM02-881 M01250M M01246M

• Suitable for use in ELISA • MAbs produced in vivo CAPTURE DETECTION M01341M M01340M M01342M M01340M

* Also works in IHC

癌症抗原 242 (CA242)

多抗 CATALOG SOURCE FORMAT

APPLICATION

CA242与唾液酸化刘易斯血型抗原有关但是化学层面和免疫层 面有所不同。它被用作胰腺癌早期诊断肿瘤标志物。已经证明 CA242和CA19-9表位为相同黏蛋白共表达表位。但是,CA242 表位的详细结构未被建立。CA242的特异性在诊断胰腺癌方面 高于CA19-9,在多种器官癌症之间以及癌症开始与恶化之 间,CA19-9和CA242的相对表达有所不同。 抗原 A01267H • Cell culture derived protein • Suitable for use as a calibrator Please note that cell culture derived antigens offer several advantages over the native fluid versions, including greater availability of the product.

K10290G Goat

Neat

ELISA

抗原 A01442H

• Native antigen from human fluids • Suitable for use in ELISA • 98% (SDS PAGE) • Purified antigen from cell culture • Suitable for use in CLIA • > 95% pure (SDS-PAGE), immunoaffinity purified • Native antigen from human fluids • Suitable for use in ELISA • P urified antigen from cell culture • > 50% pure (SDS-PAGE) • P urified antigen from human colon adenocarcinoma cell line •  95% pure (SDS-PAGE)

A32321H

A86808H

A32030H

A38151H

Please note that cell culture derived antigens offer several advantages over the native fluid versions, including greater availability of the product.

12

www.MeridianLifeScience.com | 12 .MeridianLifeScience.co

产品列表续

CD3 CD3包括4链蛋白复合物,需要T细胞活化。CD3能在T细胞发展 的所有阶段检出。研究表明具有无反应CD3受体的患者头颈鳞 状细胞癌的复发率较高。CD3正在被研究用作1性糖尿病和其他 全身免疫疾病的目标免疫抑制剂疗法。 单抗 • Produced in vivo MAL66-801

过氧化氢酶

过氧化氢酶是保护细胞免受活性氧氧化损伤的重要酶。尽管机制 不明,但是过氧化氢酶会在肿瘤发生时水平下降。目前建议使用 其作为乳腺癌诊断、预后和治疗的生物标志物。 抗原 A50136H • Native antigen from human erythrocyte • 95% pure (SDS-PAGE) • > 50,000 units/mg protein (lot dependent)

CD4

组织蛋白酶B

CD4阳性细胞是大部分活化和调节宿主感染防御活动的关键,是 许多自身免疫疾病的发病机理的核心。此外,CD4和CD8评估可 有助于淋巴瘤分类,确定适当疗法。 单抗 • Suitable for use in FC • Lyophilized P42398M

组织蛋白酶B是肽酶CI家族的成员,在新陈代谢期间有肌肉组织 生成。目前已知该物质参与癌症进展和侵袭,尤其是它可以作 为乳腺癌验证淋巴结转移的潜在预后标志物,卵巢癌肿瘤标志 物、和鼻咽癌标志物。 抗原 A50138H • Native antigen from human liver • > 95% pure (SDS-PAGE)

CD8

组织蛋白酶 D

CD9 CD9是细胞表面糖蛋白,是整联蛋白和其他跨膜4超科蛋白的复 合物。该编码蛋白在许多细胞过程中的功能和这种基因的表达在 癌细胞死亡抑制和转移中发挥关键作用。研究报告CD9减少表发 与癌细胞的侵袭行为有关。 单抗 • Suitable for use in FC • Produced in vivo MAL09-061 * Recognizes an epitope on 2nd extracellular domain (EC2) of CD9 antigen, also works in WB P42117M * Also works in IHC • Suitable for use in WB, IP and IHC • Produced in cell culture P54162M CD8是一种作为T细胞受体共受体的跨膜糖蛋白。CD8阳性T细胞 是细胞介导抗肿瘤反应的主要武器,是开发T细胞抗肺癌免疫疗法 有前途的目标。肺部肿瘤慢性诱导CD8阳性T细胞机能障碍,使 其对活化诱导细胞死亡敏感,与较差的临床反应有关。 单抗 • Produced in vivo MAL08-804

组织蛋白酶D是一种肽酶AI家族的天冬氨酸蛋白酶,能清除一些 基质如纤连蛋白和层连蛋白。它可以用作乳腺癌的预后因素,尤 其是能作为淋巴结阴性乳腺癌早期复发和死亡的独立预测指标。 这一基因额突变参与一些疾病如阿兹海默病的发病机理。 多抗 CATALOG SOURCE FORMAT APPLICATION K50161R Rabbit Purified ELISA,WB 抗原 A50161H • Native antigen from human liver • 95% pure (SDS-PAGE), lyophilized

CD1d

CD1d编码跨膜糖蛋白CD1家族的相异成员,结构上与主要组 织相容复合体(MHC)相关,并通过β2微球蛋白形成异二聚 体。研究表明乳腺癌细胞通过下调CD1d,并随后台币NKT-介 导的抗癌抗菌素免疫力,增加转移瘤恶化的潜能。 单抗 • Suitable for use in IHC and IP • Produced in cell culture P01242M

13

13 | Cancer & Tumor Markers for Assay Development

ancer Tu or arkers - Reagents for Assay Development

CD13 (氨肽酶 N)

CD28 CD28是一种表达在T细胞上的蛋白,能提供T细胞活化和存活的 协同刺激信号。它还是CD80和CD86蛋白的受体。研究表明它 是与多发性骨髓瘤肿瘤扩散有关的标志物。 单抗 • Induces T-cell proliferation in co-stimulation with CD2 monoclonal antibodies • Suitable for use in FC • Produced in vivo P42235M

CD13是一种Zn2+独立膜结合内肽酶,能优先降解蛋白和N端中性 氨基酸多肽。它与不同人体癌症有关,是抗癌疗法的合适目标。 单抗 • Suitable for use in FC and IHC • Produced in cell culture, biotin conjugated P01150B

CD15

CD15是一种细胞表面糖蛋白和具有共端pentasaccaharide 糖脂如Lewisx(Lex)抗原的复合物丛。在造血中,CD15对诊 断霍奇金病和确定急性白血病特征十分重要。CD15可用作神经 胶质瘤组织病理学分级和区分恶性胶质瘤和非肿瘤胶质细胞。 如CD15为阳性,肝细胞、胃部和结肠癌以及甲状腺髓样癌的预 后会较差。 单抗 • Suitable for use in FC, IHC and IFA • Produced in cell culture P01158B CD19 CD19是一种与CD21共受体且是重要的传导分子,参与B淋巴 细胞发展、活化和分化的调节。CD19能提供有用的B淋巴增生 性障碍疾病研究的诊断信息。 单抗 • Can be used to enumerate B-cells in peripheral blood or tissue • Produced in cell culture P01141M • Suitable for use in FC • Produced in vivo , lyophilized P42313M CD24 CD24是一种热稳定抗原,是表达在许多质量类型中的表面标志 物。它是癌症干细胞标志物,许多研究建议CD24阳性肿瘤与一 些癌症类型较差的预后有关。 单抗 • Recognizes B-cells from pre-B to mature-B stage

CD29 (整合蛋白beta-1)

CD29是一种与非常晚期抗原受体有关的整合蛋白。它作为癌 症干细胞和癌症转移的标志物。癌症干细胞因CD24、CD29和 CD49富集,具有着更高的转移能力。 单抗

• Suitable for use in FC and IFA • Produced in vivo , lyophilized P42598M

CD30

CD30是一种肿瘤坏死因子受体家族的细胞膜蛋白和肿瘤标志 物。CD30与间变性大细胞淋巴瘤有关。它表达在胚芽恶性上皮 瘤和典型霍奇金淋巴瘤Reed-Sternberg细胞上。2011年,FDA 批准竞争性抗CD30药物Brentuximab vedoti用于CD30阳性淋 巴瘤的治疗。 单抗 • Suitable for use in FC, IHC and IFA • Produced in vivo , lyophilized P42705M CD37 CD37抗原是一种前B到外周成熟B细胞期间高度表达于B细胞的 跨膜四蛋白超科跨膜蛋白。在正常组织中,CD37表达仅限于淋 巴组织。但是CD37高度表达于非霍奇金淋巴瘤和慢性淋巴细胞 白血病的恶性B细胞,因此CD37是B细胞恶性肿瘤有前途的治疗 目标。 单抗 • Suitable for use in ELISA, IHC and IP • Produced in vivo K8A069M

• Suitable for use in FC and IHC • Produced in vivo , lyophilized P42118M

14

www.MeridianLifeScience.com | 14 .MeridianLifeScience.co

产品列表续

CD49f (整合蛋白α -6)

CD40

CD49f是1型跨膜蛋白,存在于血小板、巨噬细胞、单核细胞、 胸腺细胞和T细胞。CD49f结合CD61,是癌症干细胞可能的标 志物,还可能作为潜在的癌症转移治疗目标。 单抗 • Recognizes the alpha chain of the CD49 alpha 2/beta 1 complex • Suitable for use in IHC, FC and IFA • Produced in vivo , lyophilized P42769R CD56 (神经细胞粘着分子或NCAM) CD56是一种亲同种抗原糖蛋白,通常表达于神经元、神经胶 质、骨骼肌和自然杀伤细胞表面。一些不同的肿瘤类型具有 CD56呈阳性的特征,包括骨髓瘤、骨髓性白血病、神经内分泌 瘤、肾母细胞瘤、神经母细胞瘤、NK/T细胞淋巴瘤和尤因肉瘤 肿瘤家族。 单抗 • Recognizes the 180, 145 and the 125 KDa isoforms of CD56 • Suitable for use in IHC • Produced in vivo , biotin conjugated P01176B

CD40是一种TNF受体超科成员,广泛表达与抗原细胞,并需要 活化。CD40表达表明有大范围的肿瘤细胞,包括非霍奇金和霍 奇金淋巴瘤、骨髓瘤、以及一些癌症包括鼻咽癌、膀胱癌、子宫 颈癌、肾癌和卵巢癌。CD 40有成为动脉粥样硬化不稳定生物标 志物的潜力。 单抗

• Suitable for use in FC and IFA • Produced in vivo , lyophilized P42374M

CD42

CD42是一种细胞表面糖蛋白,参与细胞间相互作用、细胞粘着 和迁移。它广泛参与细胞功能包括淋巴细胞活化、再循环、归 位、造血和肿瘤转移。 单抗 • Specific for CD42a within the intact CD42a-d complex

• Suitable for use in FC, IFA and IP • Produced in vivo , FITC labelled N42538F • Specific for CD42b • Suitable for use in FC • Produced in vivo , lyophilized N42409M • Specific for CD42b • Suitable for use in FC and IFA • Produced in vivo , FITC labelled P42648F

CD57

CD57是一种具有细胞粘着功能的糖蛋白,通常表达与NK细胞。 它作为NK细胞和神经内分泌瘤的标志物,有助于将高阶段前列 腺癌(CD57 阳性)同高阶段尿路上皮癌(CD57阴性)区分开 来。 单抗 • Suitable for use in WB, IHC and FC • Produced in cell culture P01287M

CD49d

CD49d是一种整合蛋白α亚基,由1个β4(CD49d)和1个β1 (CD29)链构成,作为VCAM-1和纤连蛋白的受益。它在单核 细胞、T细胞和嗜酸细胞中正常表达,主要功能是细胞粘着和信 号分子。在癌症中,它是慢性淋巴细胞白血病患者独立的癌症恶 化标志物。 单抗

CD59

CD59是一种表达于所有人外周血液白细胞、红细胞的糖蛋白和 一些人体细胞系的糖蛋白。它是补体膜攻击复合物活动的有效抑 制剂。它的过表达在许多实体瘤中被发现,如胰腺癌和肺癌。 单抗 • Reacts with a well-defined epitope (W40, R-53) on CD59 • Suitable for use in FC and IP • Produced cell culture MAL59-043

• Suitable for use in FC and IFA • Produced in vivo , lyophilized P42764M

15

15 | Cancer & Tumor Markers for Assay Development

ancer Tu or arkers - Reagents for Assay Development

CD90

CD66b CD66b是癌胚抗原相关细胞粘附分子8(CEACAM8),主要表 达在粒细胞如GPI锚着分子,它的主要功能是细胞粘着、细胞迁 移和病原体结合。在正常条件下,中性粒细胞的CD66b表达很 少,但是在慢性慢性粒细胞白血病中,它的表达会增加。 单抗

CD90是细胞表面糖蛋白,参与细胞粘着和大量细胞类型的细胞 信息传递,尤其在免疫和神经系统的细胞。它广泛用作造血干细 胞标志物,区分上皮样间皮瘤和肺癌方面是有价值的标志物。它 还可以作为鼻咽癌的肿瘤抑制剂。 单抗 • Suitable for use in WB, IFA, FC, and IP • Produced in cell culture P01283M

• Suitable for use in FC and IFA • Produced in vivo , FITC labelled P42531F

CD103

CD71 CD71,转铁蛋白受体,参与细胞铁质摄取,通过高度增殖表达 在细胞上。数据表明它与促进乳腺内分泌拮抗增加有关,可以作 为三苯氧胺耐药性和不良治疗结果的预后标志物。 单抗 • Recognizes soluble and bound transferrin receptor • Suitable for use in ELISA and WB • Produced cell culture H01372M • Suitable for use in ELISA and WB • Produced in vivo H86602M

CD103是表达于T细胞的整合蛋白,在毛细胞白血病中升高。通 常用于流失细胞和IHC试验鉴别外周血毛细胞白血病、骨髓穿刺 液和组织样品。 单抗 • Suitable for use in IHC, IFA, IP and FC • Produced in vivo , lyophilized P42318M

CD105 (内皮因子)

CD105是转化生长因子beta受体系统的辅助泛白,表达在血管 内皮细胞上。研究已经表明CD105在一些实体瘤中表达,表达 水平与多种临床病理因素包括存活期缩短、出现转移有关。它 是肾细胞癌患者死亡风险和不利预后的独立标志物。 单抗 • Suitable for use in WB, IP and FC • Produced in vivo MAL105-226

CD77

CD77是2型膜蛋白,伯基特淋巴瘤的标志物。它还是志贺毒素 和志贺样毒素1的受体,有一些大肠杆菌、痢疾杆菌会生成 CD77。 单抗 • Suitable for use in IHC, IFA, and FC • Produced in vivo P42175R

CD147

CD147是一种细胞外基质金属蛋白酶诱导物,与多种人体恶性 肿瘤侵袭包括卵巢和胃癌有关。它的表达与癌症侵袭和转移高 度相关,有作为预后标志物的潜力(如不良预后)。 单抗 • Recognizes an epitope in the N-terminal Ig domain (D1) • Suitable for use in FC • Produced in vivo P87535M * Also works in WB and IP

16

www.MeridianLifeScience.com | 16 .Meridia Life cie ce.c

产品列表续

CD152 (CTLA-1)

着丝点蛋白B (CENPB)

CD152是参与下调T细胞活性、下调免疫反应的关键受 体。CD152表达增加在慢性淋巴细胞白血病中被观测到, CD152可能抑制宿主白血病细胞免疫应答,有助于疾病发展。 单抗 • Suitable for use in IHC, FC and ICC • Produced in vivo , lyophilized P91207M

CENPB是一种高度保守的DNA蛋白,促进着丝点形成。它用作 自身免疫疾病的血清学标志物,尤其是硬化和其他风湿病。它 还是小细胞肺癌的潜在标志物和乳腺癌的预后标志物。 抗原 A01375H • Recombinant ( Sf9 Insect Cells) • Suitable for use in ELISA and WB • > 95% pure (SDS-PAGE)

R01646

• Recombinant ( Sf9 Insect Cells) • Suitable for use in ELISA and WB • 90% pure (SDS-PAGE)

CD177

CD177是中性粒细胞重要的膜糖蛋白,作为骨髓及外骨髓增殖 疾病的标志物。失去CD177表达与乳腺癌患者较多的转移事件 和较短的存活期有关。 单抗 • Suitable for use in WB, FC and IP • Produced in vivo MAL177-166

血浆铜蓝蛋白 血浆铜蓝蛋白是一种运输血清铜质的标志物。它主要用于诊断 威尔森氏病,一种罕见的与肝脏、大脑和其他器官铜超量储存 的遗传病。血清铜蓝蛋白可以有助于晚期实体恶性肿瘤癌症的 标志物。 抗原 A50143H • Native antigen from human plasma • > 95% pure (SDS-PAGE), lyophilized c-Myc 该物质多功能核磷蛋白,在细胞周期进程、细胞凋亡和细胞转化 中发挥作用。许多癌症中,突变导致该物质连续表达,包括伯基 特淋巴瘤、子宫颈、卵巢、结肠、乳腺、胃部和肺部癌症。 单抗 • Produced in vivo MAB07-510 * Suitable for use in WB and IHC

CD195 (CCR5)

CD195是一种位于包含在免疫系统中白细胞表面的蛋白,它作 为趋化因子尤其是CCL3(MIP1α),CCL4(MIP1β)和CCL5 (RANTES)。它还被HIV使用进入目标细胞。CD195在乳腺癌 和结肠直肠癌转移中发挥作用。 单抗

• Suitable for use in FC • Produced cell culture P01240M

17

17 | Cancer & Tumor Markers for Assay Development

Cancer & Tu or Markers - Reagents for Assay Development

细胞角蛋白 21-1, 细胞角蛋白19片段 该物质是肺癌尤其是鳞状细胞亚型灵敏而特异的肿瘤标志 物。2011年FDA批准细胞角蛋白21-1试验监测肺癌患者的疾病预 后和治疗。有报告称它还是卵巢癌的潜在生物标志物。 单抗 • Suitable for use in ELISA • Produced in vivo M01300M 抗原 A32340H • N ative antigen from MCF-7 Cell Supernatant • C alibrator Grade with low cross-reactivity • Suitable for use in CLIA VI型胶原蛋白 VI型胶原蛋白广泛分布于细胞外基质高分子钟,在组织发展中 发挥关键作用,癌症发生时高度表达。研究显示它促进化疗耐 药性,尤其在乳腺癌中它调节癌症预后和转移。 抗原 A33129H • Native antigen from human placental villi • S uitable for use as a standard, or for antibody production • > 90% pure (SDS-PAGE) IV型胶原蛋白 IV型胶原蛋白是一种在所有基底膜中发现的外基质蛋白,形成超 分子网络影响细胞粘着、迁移和上皮细胞分化。患有胰腺癌的患 者显示出IV型胶原蛋白循环水平显著增加,表明它可以作为生物 标志物。 多抗 CATALOG SOURCE FORMAT APPLICATION T40251R Rabbit Purified ELISA,IFA,IHC T33340G Goat Aff.Pur. ELISA,ICC,IHC,WB 抗原 A33125H • Native antigen from human placental villi • S uitable for use as a standard or for antibody production • > 90% pure (SDS-PAGE)

防御素-beta

人体防御素是小型阳离子多肽,该物质由中性粒细胞和上皮细胞 形成,他们形成2种主要的亚族α和β。防御素参与多种先天和获 得性免疫活动,最近β防御素的单核苷多态性被发现与癌症的敏 感性增加有关。尤其是在口腔癌中,β防御术下调表明它在肿瘤 抑制中发挥作用。 单抗 • Suitable for use in ELISA • Produced in cell culture, lyophilized EPITOPE BINDING P24141M a.a. 1-36, Defensin-beta 1 * Also works in WB P24011M a.a. 4-41, Defensin-beta 2 抗原 A24100H • S ynthetic peptide representing a.a. 4-41 (Defensin-beta 2) • > 95% pure (HPLC), lyophilized A24601H • S ynthetic peptide representing a.a. 3-39 (Defensin-beta 4) • > 95% pure (HPLC), lyophilized

肌间线蛋白

该物质是III型平滑肌组织中间丝状体,功能广泛。一些研究已经 显示该物质是内皮细胞分化和一些类行肿瘤侵袭的高度灵敏标志 物,包括结肠癌、胃肠道间质瘤和胚芽肉瘤。 单抗 • Produced in vivo MAM26-014

18

www.MeridianLifeScience.com | 18 .Meridia Life cie ce.c

产品列表续

桥粒胶蛋白3

表皮生长因子 (EGFR) EGF是一种与它的受体EGFR结合刺激细胞生长、增殖和分化的生 长因子。EGF调节异常和导致EGFR过表达的突变与一些癌症有 关,包括肺癌、乳腺癌、肛门癌以及胶质母细胞瘤。许多治疗方 法以EGFR为目标如西妥昔单抗和帕尼单抗。 单抗 • Suitable for use in ELISA (unless stated otherwise) • Lyophilized • Produced in cell culture (unless stated otherwise) K67138M * Recognizes the C-terminus a.a. 1165-1186, also works in IB, ICC and IP P24100M * Does not cross-react with v-erb-B, also works in IHC and FC P24200M * Does not cross-react with v-erb-B, also works in IHC and FC K67190M * Recognizes site phosphorylated at Serine 1047, also works in IB, ICC and IP K67902M * Recognizes site phosphorylated at Tyrosine 1173, also works in IB, ICC and IP K67123M * Recognizes site phosphorylated at Tyrosine 845, also works in IB K01101B

桥粒胶蛋白3是一种钙依赖糖蛋白,位于分层上皮细胞的桥粒连 接。它是区分非小细胞肺癌主要亚型腺癌和鳞状细胞癌的灵敏儿 特异的标志物。 单抗 • Suitable for use in WB and IHC • Produced in cell culture H44350M

素昂唾液栓神经节苷脂GD2

该物质是一种唾液酸耐受糖脂了,表达在所有哺乳动物细胞的 表面。研究显示它是人体黑素瘤和神经母细胞瘤细胞毒性抗体 的抗原目标。GD2的相对治疗特异性表达使得其成为单克隆抗 体或人工T细胞受体的免疫疗法目标。 抗原 A86168H • Native antigen from human brain • > 98% pure (HPTLC), lyophilized

* Recognizes the extracellular domain, suitable for use only in IHC and FC, biotin conjugated and liquid form * Recognizes site phosphorylated at Tyrosine 1045, also works in IB and IP, liquid form

弹性蛋白酶

K67112M

弹性蛋白酶是一种丝氨酸蛋白酶,特别是嗜中性粒细胞形式的弹 性蛋白酶是218氨基酸长,2天冬酰胺链糖链。它由嗜中性粒细 胞和巨噬细胞在炎症期间分泌用来摧毁细菌和宿主住址。研究表 明嗜中性粒细胞弹性蛋白酶可以加速癌症恶化,肿瘤组织内的免 疫反应嗜中性粒细胞弹性蛋白酶是乳腺癌和肺癌患者独立的预后 指标。 抗原 A01683H • Native antigen from human neutrophils • Suitable for use in ELISA and WB • 90% pure SDS-PAGE (Chromatography) A50145H • Native antigen from human neutrophils • > 95% pure (SDS-PAGE), lyophilized 多抗 CATALOG SOURCE FORMAT APPLICATION K90052C Sheep Purified WB

抗原 VTI880

• Recombinant EGF (P. pastoris) • Suitable for use in WB • 95% pure (SDS-PAGE) • Recombinant EGF (P. pastoris) • Suitable for use in WB • > 95% pure (SDS-PAGE)

VTI882

A42115H

• Recombinant EGFR (E. coli) • C ontains less than 1% dimers and aggregates • >98% pure (RP-HPLC and SDS-PAGE), lyophilized • S ynthetic EGFR Peptide phosphorylated at Tyr 1173 • Peptide sequence TAENAE-pY-LRVAPQSS • Purified and lyophilized • S uitable for use as a control/blocking phosphopeptide for use with monoclonal antibody, Catalog# K67902M

A67902H

19

19 | Cancer & Tumor Markers for Assay Development

ancer Tu or arkers - Reagents for Assay Development

细胞粘附分子 (EpCAM) 该物质是参与细胞间粘着、信号传播、细胞迁移、增殖和分化的 糖蛋白。它的表达限制于健康个体的正常上皮细胞,但是在癌症 中它的表达分布随着癌症的不同而变化。它被视为肿瘤先关抗原 并在多种癌症中发挥预后标志物的作用。 单抗 • Suitable for use in ELISA and WB • Produced in vivo M01310M * Recognizes a.a. 116-242 erbB-2, HER2/neu 受体酪氨酸蛋白激酶erbB-2通常称为HER2(人类表皮生长因子 2),是人类表皮生长因子家族成员。HER2的过表达在特定侵 袭性乳腺癌的发展和恶化中发挥着重要作用。大约15%的新诊断 乳腺癌为HER 2阳性,HER2检测的目的时间别患者是否能从 HER2靶向疗法中获益,如曲妥单抗、拉帕替尼、帕托珠单抗和 TDM1。 单抗 • Reacts with peptide ILDV4 • Suitable for use in ELISA • Produced in vivo M01296M * Reacts with peptide ILDV4 (dephosphorylated) M01297M * Reacts with peptide ILDV4 (phosphorylated) M01298M * Reacts with peptide ILDV2 (dephosphorylated) M01299M * Reacts with peptide ILDV2 (phosphorylated) 抗原 R01605 • Recombinant (HEK293 cells) • Suitable for use in ELISA •  95% Pure (SDS-PAGE), lyophilized, contains a His-tag

Factor H (Beta 1H)

H因子是补体活化家族的调节剂成员,它是补体调控蛋白。异常 的H因子活性的临床意义包括中风、精神分裂和癌症。尤其是它 可以作为膀胱癌的肿瘤标志物。 多抗 CATALOG SOURCE FORMAT APPLICATION K90030C Sheep Purified DD,IE,IEP

Factor VIII (FVIII)

该物质是关键的凝血蛋白,还被称为抗血友病因子。在恶性肿瘤 中抑制该物质导致后天血友病并增加深静脉血栓和肺栓塞风险。 单抗 • Antibody binds human factor VIII A2 domain in immunoblotting techniques • Suitable for use in ELISA and WB N01277M

酸性纤维母细胞生长因子 (FGF-acidic, FGF-1)

FGF家族包括FGF1(酸性FGF)、FGF2(基础GF)、FGF6和 FGF8,它们全部参与多种生物过程,包括胚胎发育、细胞生 长、形态发生、组织修复、肿瘤生长和侵袭。尤其是它在前列腺 癌上皮细胞上调,促进了肿瘤进展和临床侵袭。它被视为治疗目 标,尤其是那些以FGF受体和/或FGF信号为目标的疗法可以直 接影响肿瘤细胞和肿瘤血管生成。 抗原 A42117H • FGF-acidic recombinant (E. coli) • Contains less than 1% dimers and aggregates • >95% pure (HPLC, FPLC and reducing and non-reducing SDS-PAGE), lyophilized

A42118H

• FGF-basic recombinant (E. coli) • Contains less than 1% dimers and aggregates • > 98% pure (RP-HPLC and SDS-PAGE), lyophilized

20

www.MeridianLifeScience.com | 20 .M ridia if ie .c

产品列表续

抗体配对 • Suitable for use in ELISA • Produced in vivo CAPTURE DETECTION H86504M H86045M

纤连蛋白 纤连蛋白是一种多功能细胞外基质糖蛋白,细胞外基质结合膜 横跨受体蛋白成为整合蛋白。它在细胞粘着、增殖、迁移和分 化中发挥重要作用,它在诸如伤口愈合、胚胎发育中发挥重要 作用。纤连蛋白和整合蛋白受体在肿瘤的发展和转移中发挥着 重要作用。 单抗 • Reacts with the central domain • Suitable for use in ELISA and WB • Produced in vivo H01282M • No cross-reactivity with alpha1-acid glycoprotein, serum albumin or other serum proteins • Produced in vivo M45216M 抗原 A63874H • Native antigen from human plasma • > 95% pure (SDS-PAGE) 甘油醛-3-磷酸脱氢酶(GAPDH) 该物质催化该甘油醛3磷酸向D甘油酸酯1,3二磷酸转化,在糖酵 解中这是过程的第6步。它在多种人体癌症如皮肤黑素瘤中过表 达,它的表达阳性与肿瘤进展有关。它已经被认为与一些神经推 行性疾病鱼有关。 单抗

* Reacts with monomeric and dimeric forms (not tetrameric form), also works in WB

H86504M H86903M

蛋白多糖-1 (GPC1) GPC1是细胞表面蛋白多糖,是细胞和细胞外基质的丰富成分。 它通过促进生成配体受体混合物作为共受体,有效降低所需的配 体浓度。GPC1已经被认为与神经胶质瘤、胰腺癌、和乳腺癌的 肿瘤形成作用有关。尤其是GPC外来体阳性可以作为无创诊断 和筛查工具检测早期胰腺癌。 单抗 • Recognizes native and recombinant human GPC1 • Suitable for use in ELISA, IFA and IB • Produced in vivo M01253M 热休克蛋白 热休克蛋白是参与蛋白折叠、稳定和传输以及转录调节的蛋白。 它们还参与许多病变如哮喘、内膜增生以及胰岛素抵抗。此外它 们还发挥细胞保护作用而且是肿瘤存活的关键,并经常在癌症中 上调。尤其是,HSP20还有可能作为结肠直肠癌的有价值的预后 标志物,HSP27可以作为前列腺癌的预后标志物。 单抗 • Suitable for use in ELISA, WB and IFA • Produced in vivo H86201M * Recognizes human recombinant HSP20 and HSP20 from human cardiac tissue

• Suitable for use in ELISA and WB • Produced in vivo , HRP conjugated

H86045P H86504P

* Reacts with monomeric and dimeric forms (not tetrameric form), also works in IFA and ICC

21

21 | Cancer & Tumor Markers for Assay Development

Cancer & Tu or Markers - Reagents for Assay Development

抗原 A01469H

人附睾蛋白 4 (HE4) HE4属于乳清酸4二硫化物核蛋白家族,目前HE4的生物功能未 知。HE4表达发现于生殖系统腺上皮、末梢肾小管和呼吸道上 皮细胞。在癌症中,发现于浆液卵巢癌和子宫内膜样癌。HE4 的主要作用是监测具有些许或无CA125表达的卵巢期患者治疗 后水平的升高。 抗体配对 • Suitable for use in ELISA • Produced in vivo CAPTURE DETECTION 血红蛋白 血红蛋白是红细胞中运输氧气的含铁金属蛋白。在与结肠直肠癌 等消化道出血有关的疾病中,血红蛋白渗入到胃肠道中,然后随 粪便一起排出。粪便隐血试验(FOBT)是探测粪便中血液的特定 检验。许多商业检测是ELISA或者使用血红蛋白特异性抗体的侧向 流抗原检测。 抗体对 • Suitable for use in ELISA CAPTURE DETECTION H01417M H01416M *Hemoglobin H01416M H01368M *HbA1c H01416M H01369M *HbA1c • MAb to Hemoglobin (FOB) • Recognizes Human Hemoglobin • Suitable for use in Lateral Flow and Turbidimetry (Latex) CAPTURE DETECTION H01409M H01410M 抗原 A01703N • S uitable for use in LF • P urified, Liquid

• N ative antigen from human epididymis cell line • Suitable for use in CLIA • Native antigen from human fluids • Suitable for use in CLIA • 90% Pure (SDS-PAGE)

A01466H

胰岛素样 生长因子I (IGF-I 或生长调节素C) 该物质是参与调节人体生长和发展的肽激素,和胰岛素有类似的 分子结构。它主要通过肝脏作为内分泌激素产生,是一种较强的 分裂素广泛见于癌症细胞系如肉瘤、白细胞、前列腺癌、乳腺 癌、肺癌、结肠癌、胃癌、食道癌、肝癌、胰腺癌、肾癌、甲状 腺癌、脑癌、卵巢癌和子宫癌(宫颈和内膜)。 抗原 • Suitable for use in ELISA and RIA • Produced in cell culture E54061M 抗原 A42111H • Recombinant (E. coli) • Contains less than 1% dimers and aggregates • > 95% pure (RP-HPLC and SDS-PAGE), lyophilized 5-羟基甲基尿苷 该物质在电离辐射和活性氧氧化DNA期间由胸苷形成,可由炎 症反应构成。该过程导致基因突变,变更基因表达和染色体不 稳定,通常和老化、癌症和自身免疫疾病有关。尤其是5羟基甲 基尿苷可作为乳腺癌标志物。 多抗 CATALOG SOURCE FORMAT APPLICATION K2B400G Goat Neat ELISA

M01323M M01320M M01323M M01321M M01323M M01322M

22

www.MeridianLifeScience.com | 22 .M ri i if i .c

产品列表续

胰岛素样生长因子结合蛋白3(IGFBP-3) IGFBP-3是在肝脏中产生的转运蛋白,主要通过结合蛋白胰岛素样 生长因子-1(IGF-1)调节生长。高循环浓度的IGF-I增加癌症 (尤其是乳腺癌)风险,而IGFBP-3浓度则与降低癌症风险相关。 Antibody Pairs • Suitable for use in CLIA, ELISA and RIA • Recognizes native and recombinant Human IGFBP-3 CAPTURE DETECTION K01411M K01410M 整合蛋白α M (CD11b/MAC-1) 整合蛋白αM亚型也称为MAC1α亚型或CD11b,它结合了整合 蛋白β2亚型(CD18)形成非公价异质二聚体整合蛋白αM/β2, 也称为MAC-1受体。该物质胃癌患者独立的预后因素,也是淋 巴结转移和肿瘤大小的预后因素。 单抗 • Suitable for use in IHC, IFA and FC • Produced in vivo , lyophilized P42190M • Produced in vivo , FITC labelled P42530F 干扰素β(IFN-beta) 干扰素β通过成纤维细胞大量生成,在先天免疫反应中发挥重要 作用。它可以用作多发性硬化的治疗,降低复发率。癌症功能 研究也认为该物质可以作为治疗血管生长的自然抑制剂并限制 肿瘤生长。 单抗 • Suitable for use in ELISA, WB, IHC and IP • Produced in vivo , lyophilized P01266M

干扰素γ (IFN-gamma) 该物质是一种细胞因子,在促进先天和适应性免疫反应方面在 生理学层面发挥重要作用。在癌症中。它能防止原发性肿瘤的 发展,调节肿瘤生长,促进宿主对肿瘤的反应。 单抗 • Suitable for use in ELISA • Produced in vivo P18442M * Neutralizing antibody, lyophilized P86424M * Also works in WB 抗体配对 • Suitable for use in ELISA and WB • Produced in vivo CAPTURE DETECTION P86842M P01309M 抗原 A42302H • Recombinant (E. coli) • > 98% (SDS-PAGE and RP-HPLC analysis), lyophilized

白介素1号α (IL-1a) 和 白介素1号受体(IL-1R)

IL-1a多效细胞因子位于细胞质基质或细胞膜,是一种能调节细 胞内环境的物质。它的受体是IL-1R,负责调解它的作用。已知 它能在多种肿瘤类型中上调,并作为肿瘤恶化因子、转移表达因 子、血管生成基因和生长因子。 抗原 A42201H • Recombinant IL-1a (E. coli) • > 97% pure (HPLC and SDS-PAGE), lyophilized

23

23 | Cancer & Tumor Markers for Assay Development r

r rk rs - Reagents for Assay Development

核纤层蛋白 该物质是核纤层的主要成分,具有多种功能包括细胞核结构支 持、促进染色质促成、基因调节和DNA修复。它们经常异常表达 或位于肿瘤内,因肿瘤亚型而异,它们可以作为患者良好或较差 存活的标志物。在前列腺癌中,它参与细胞增殖、迁移和侵袭。 单抗 • Reacts with Lamin isotypes of 60-75 kDa • Suitable for use in WB, IFA and IHC M01259M * Lyophilized M44546M 多抗 CATALOG SOURCE FORMAT APPLICATION T24210R Rabbit Purified IHC,WB T24210R is specific for Lamin 5 抗原 A24210H • Native Lamin 5 from human foreskin keratinocytes 瘦蛋白 瘦蛋白是一种由脂肪细胞组成的激素,有助于通过抑制饥饿和调 节脂肪储备调节能量平衡。在癌症中,瘦蛋白表达能诱导经常出 现于实体瘤的缺氧条件。瘦蛋白在一些类型的癌症如乳腺癌、直 肠结肠癌、前列腺癌、卵巢癌和肺癌中表达上升。 单抗 • Suitable for use in IHC and ELISA • Produced in vivo H4A342M * Reacts with C-terminal, a.a. 92-145 抗原 A42327H • Recombinant (E. coli) • > 95% pure (RP-HPLC and SDS-PAGE), lyophilized • Suitable for use in WB • > 95% pure (SDS-PAGE)

激肽释放酶

该物质丝氨酸蛋白酶家族亚族的酶,能够清除蛋白质的肽键。在 癌症细胞系中,它们被类固醇激素上调,在前列腺癌、人腺激素 激肽释放酶(kK2)广泛用作标志物。三种其他的的激肽释放酶 是HK6、HK10和HK11,是卵巢癌、和前列腺癌诊断和预后的新 型血清标志物。 抗原 A50190H • Native antigen from human plasma • > 95% pure (SDS-PAGE), lyophilized

乳酸脱氢酶(LDH)

LDH是一种由4种亚型组成的酶,能够催化乳酸向丙酮酸转化。组 织受损期间,释放LDH,LDH参与肿瘤启动和转移。研究显示 LDH一酵素和总体LDH的表达不同,LDH表达可以作为癌症预后 的通用标志物。LDH-5在肿瘤和基质内的表达是癌症扩散和混合 型胃癌的强大预后因素。 抗原 A38357H • Native LDH sources from human heart • S pecific Activity: 260 Units/mg protein (lot dependent) • Purified by ammonium sulfate precipitation

A38155H

• Native LDH1 from human erythrocytes • S pecific Activity: 125 Units/mg protein (lot dependent) • Ammonia sulfate suspension • Native LDH2 from human erythrocytes • S pecific Activity: 300 Units/mg protein (lot dependent) • Ammonia sulfate suspension • Native LDH3 from human erythrocytes • S pecific Activity: 240 Units/mg protein (lot dependent) • Ammonia sulfate suspension • Native LDH4 from human erythrocytes • S pecific Activity: 220 Units/mg protein (lot dependent) • Ammonia sulfate suspension • Native LDH5 from human erythrocytes • S pecific Activity: 460 Units/mg protein (lot dependent) • Ammonia sulfate suspension

A38252H

A38353H

A38454H

A38558H

24

www.MeridianLifeScience.com | 24 .MeridianLifeScience.co

Page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 Page 10 Page 11 Page 12 Page 13 Page 14 Page 15 Page 16 Page 17 Page 18 Page 19 Page 20 Page 21 Page 22 Page 23 Page 24 Page 25 Page 26 Page 27 Page 28 Page 29 Page 30 Page 31 Page 32 Page 33 Page 34 Page 35 Page 36

meridianlifescience.com

Powered by