Meridian Custom Oligonucleotides Project

Oligonucleotide Quality Control

High quality and purity Manufactured in ISO 13485:2018 compliant labs, with full traceability, our oligos are produced using the latest advances in oligos synthesis and purification technologies, resulting in very high quality. ESI-MS (electrospray ionization mass spectrometry) is used to measure and control the molecular weight of the sequence and determine if there are any by-products. Purity is then verified using ultra performance liquid chromatography (UPLC) that separates oligos to a single-base resolution and capillary gel electrophoresis (CGE). This information is reported in the CoA provided with the oligo at delivery.

At the foundation of our manufacturing processes is a robust Quality Management System (QMS), driving quality assurance.

ISO 13485:2018 For manufacture and sales of oligonucleotides

Quality Systems

ESI-MS (Electrospray ionization-mass spectrometry) Ensuring the correct sequence and sensitivity detection of low levels of by-products UPLC (Ultra Performance Liquid Chromatography) High resolution and shorter separation times CGE (Capillary Gel Electrophoresis) Analysis for n-1, adducts, full-length products (ELPs) UV Spectroscopy The extinction coefficient and Beer-Lambert Law for absorbance reading to be converted to a quantity

Sequence Identify Verification

Quality Management

Purity Verification


Data Sheet / Reports / CoA Download QC-related documents


Ordering information: USA 5171 Wilfong Road Memphis, Tennessee 38134 Phone: +1 901-382-8716 Fax: +1 901-333-8223

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ISO 13485 Certified


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