Meridian Custom Lateral Flow Uncut Sheets

Meridian is a primary manufacturer of specialized high-quality molecular reagents and offers solutions to a wide range of industries to diagnose and treat diseases, discover new therapeutics or develop tests for environmental, food and cosmetic safety.

Lateral Flow Services Uncut Sheets

Meridian offers lateral flow assay uncut sheets to support your unique manufacturing needs. We provide an easy approach to start your own label of rapid diagnostic tests.

• WHO, ISO and KGMP approved top-tier production facility • Manufacturer for over 1,242 registered assays worldwide • 12 Billion test capacity per year (1 billion tests per month) • Fully automated with GMP processes and control

Structure of a Lateral Flow Immunoassay

Nitrocellulose membrane

Flow

• OEM Service -Specification can be optimized to meet the demands of our OEM partners • High Quality and Optimized Product 20 years of know-how in BSL-3 facility develop and customize products

Sample application pad

Conjugate release pad

Test line antibodies

Control line antibodies

Wicking pad

• Tier pricing structure by purchase volume • Initial testing pack - 21,000 tests (300 sheets) & minimum order unit is 7,000 tests (100 sheets)

Services

Ready-made uncut sheets

OEM manufacturing (uncut sheet assembled into a device)

Custom uncut sheets (contact us to learn more)

www.meridianbioscience.com/lifescience

READY-MADE UNCUT SHEETS: TEST MENU FOR HUMAN DIAGNOSTIC ASSAYS 39 different tests available – Customer is responsible for obtaining regulatory approval and registration under their name/brand. Many assays are approved by several regulatory agencies (CE, WHO, PQ, MFDS, TGA, Health Canada) under specific customer brands.

Respiratory

Gastrointestinal

Vector-Borne

• Influenza Ag • Legionella Ag • Respiratory Adeno Ag • RSV Ag • S.pneumoniae Ag • Strep AAg • TB MPT64 Ag • COVID/Flu Ab Combo 2.0 • COVID-19 Ag 2.0 • COVID-19 M/G Ab 2.0 • COVID-19 Spike IgG

• H.Pylori Ab • H.Pylori Ag

• Chikungunya IgM Ab • Chikungunya IgM/IgG Ab • Dengue IgM/IgG Ab

Hepatitis

• Dengue IgM Ab • Dengue NS1 Ag • Filariasis Ag • Malaria P.fAg

• Anti-HBs • HAV IgM Ab • HBsAg • HCV Ab

• Malaria P.f/P.vAb • Malaria P.f/P.vAg • Malaria P.f/pan Ag • Tsutsugamushi IgM/IgG Ab • Yellow Fever IgM Ab • Yellow Fever IgM/IgG Ab • Zika IgM Ab • Zika IgM/IgG Ab

STDs

• HIV 1/2 Ab (4-lines) • HIV 1/2 Ab (3-lines) • HIV/Syphilis Combo Ab • Syphilis Ab

Others

• Human CRP Ag • Leptospira IgM/IgG Ab • Ebola Ag

To create a lateral flow test from an uncut sheet, all you need is a two-step assembly process: first, cut the sheet into strips and second, assemble into a two-piece plastic cassette. Or alternatively, just keep the assay in the test strip format .

OPTIONAL SERVICE: ASSEMBLY INTO TEST DEVICE

INCLUDES:

• Assembly and packaging cost (including labor costs) • OEM manufacturing (customized laser printing on each device) • Consumables for the final products (OEM): Buffer, device, silica gel, pouch for packaging (also swabs if required) • Product warranty

SENSITIVITY & SPECIFICITY CUSTOMER IS RESPONSIBLE FOR OBTAINING REGULATORY APPROVAL & REGISTRATION UNDER THEIR NAME/BRAND

Respiratory Uncut Sheets

Specification Guidelines

Category

Product Name

Specimen Volume

Testing Time

Specimen

Feature

Certification

NP swab/wash/ aspirate

Sensitivity: 97.44% Specificity: 100% 8-30 mins

Respiratory

Influenza Ag

-

CE-IVD

Sensitivity: 97.67% Specificity: 99.38% LOD: 0.01 μ g/mL

Respiratory

Legionella Ag

Urine

100 μ l

5-15 mins

CE-IVD

Respiratory Adeno Ag

NP swab/Nasal swab NP swab/wash/ aspirate

Respiratory

4 drops

-

15-20 mins

CE-IVD

Sensitivity: 92.45% Specificity: 98.44% 15-30 mins

Respiratory

RSV Ag

-

CE-IVD

Sensitivity: 100% Specificity: 99.26% LOD: 1.56 x 104 CFU/mL Sensitivity: 98.2% Specificity: 99.26% LOD: 3.91 x 105 cells/mL Sensitivity: 100% Specificity: 100% LOD: 2 ng/mL

Respiratory

S. pneumoniae Ag Urine/ CSF

100 μ l

5-10 mins

CE-IVD

Respiratory

Strep A Ag

Throat swab

-

5-15 mins

CE-IVD

Liquid Culture, Solid Culture NP swab/Nasal swab

Respiratory

TB MPT64 Ag

-

10-15 mins

CE-IVD

Respiratory (COVID-19) Respiratory (COVID-19) Respiratory (COVID-19) Respiratory (COVID-19)

COVID/Flu Ag combo 2.0

4 drops

-

15-30 mins

CE-IVD

CE-IVD, WHO EUL, MFDS, TGA, Health Canada

Sensitivity: 95.92-100% (CT: ≤ 25) Specificity: 98.94%

COVID-19 Ag 2.0 NP swab

3 drops

15-30 mins

COVID-19 M/G Ab 2.0 COVID-19 Spike IgG

Sensitivity: 96.82% Specificity: 98.65% 10-15 mins CE-IVD, MFDS

WB/S/P

10-20 μ l

WB: 20 μ l, S/P: 10 μ l

Sensitivity: 100% Specificity: 100% 10-15 mins

WB/S/P

CE-IVD

GI, STD, Hepatitis, Other Uncut Sheets

Specification Guidelines

Category

Product Name

Specimen Volume WB: 20 μ l, S/P: 10 μ l

Testing Time

Specimen

Feature

Certification

Gastrointestinal

H.pylori Ab

WB/S/P

-

10-20 mins

CE-IVD

Sensitivity: 98.5% Specificity: 100% LOD: 0.97 ng/mL

Gastrointestinal

H.pylori Ag

Feces

40-70 mg

10-15 mins

CE-IVD

HIV 1/2 Ab (4-lines) HIV 1/2 Ab (3-lines)

WB: 20 μ l, S/P: 10 μ l WB: 20 μ l, S/P: 10 μ l

Sensitivity: 100% Specificity: 98.8% 10-20 mins

STDs

WB/S/P

-

Sensitivity: 99.8% Specificity: 100% 10-20 mins

STDs

WB/S/P

WHO PQ

* HIV Ab Sensitivity: 100% Specificity: 99.9%* Treponema Pallidum Ab Sensitivity: 98.8% Specificity: 100%

HIV/Syphilis Combo Ab

WB: 20 μ l, S/P: 10 μ l

STDs

WB/S/P

15-20 mins

WHO PQ

WB: 20 μ l, S/P: 10 μ l

Sensitivity: 100% Specificity: 100% 5-20 mins

STDs

Syphilis Ab

WB/S/P

CE-IVD

Sensitivity: 98.5% Specificity: 98% 15-30 mins Sensitivity: 100% Specificity: 98.04% 15-20 mins Sensitivity: 100% Specificity: 100% 20-30 mins

Hepatitis Hepatitis Hepatitis

Anti-HBs

WB/S/P WB/S/P WB/S/P

100 μ l

- - -

HAV IgM Ab

10 μ l

HBsAg

100 μ l

WB: 20 μ l, S/P: 10 μ l

Sensitivity: 100% Specificity: 97.67% 5-20 mins WHO PQ, CE-IVD

Hepatitis

HCV Ab

WB/S/P

Others

Human CRP Ag Leptospira IgM/ IgG Ab

WB/S/P

5 μ l

-

3 mins

CE-IVD

Sensitivity: 96.6% Specificity: 98.6% 15-20 mins

Others

WB/S/P

10 μ l

CE-IVD

Others

Ebola Ag

WB/S/P

100 μ l

-

20-30 mins

CE-IVD

www.meridianbioscience.com/lifescience

WB: Whole Blood. S: Serum. P: Plasma. NP: Nasopharyngeal

CUSTOMER IS RESPONSIBLE FOR OBTAINING REGULATORY APPROVAL & REGISTRATION UNDER THEIR NAME/BRAND

GI, STD, Hepatitis, Other Uncut Sheets

Specification Guidelines

Category

Product Name

Specimen Volume

Specimen

Feature

Testing Time Certification

Chikungunya IgM Ab

Vector-borne

-

-

-

-

-

Chikungunya IgM/IgG Ab

Sensitivity: 97.7% Specificity: 99.6% 15-20 mins

Vector-borne

WB/S/P

10 μ l

CE-IVD

Dengue IgM/IgG Ab

Sensitivity: 97.5% Specificity: 97.2% 15-20 mins

Vector-borne

WB/S/P

10 μ l

CE-IVD

Vector-borne Dengue IgM Ab

-

-

-

-

-

Sensitivity: 92.9% Specificity: 98.7% LOD: 0.5 ng/mL

Vector-borne Dengue NS1 Ag

WB/S/P

100 μ l

15-20 mins

CE-IVD

Sensitivity: 100% Specificity: 100% 10-20 mins

Vector-borne

Filariasis Ag

WB/S/P

2 drops

CE-IVD

Tsutsugamushi IgM/IgG Ab Yellow Fever IgM Ab Yellow Fever IgM/ IgG Ab

Vector-borne

WB/S/P

10 μ l

-

15-20 mins

CE-IVD

Sensitivity: 100% Specificity: 98.3% 15-20 mins

Vector-borne

WB/S/P

10 μ l

CE-IVD

Vector-borne

-

-

-

-

-

Sensitivity: 98% Specificity: 100% 15-20 mins

Vector-borne

Zika IgM Ab

WB/S/P WB/S/P

10 μ l 10 μ l

CE-IVD CE-IVD

Vector-borne Zika IgM/IgG Ab

-

15-20 mins

* Venous Whole Blood Sensitivity: 99.59% Specificity: 100% * Capillary Whole Blood Sensitivity: 99.38% Specificity: 100%

Vector-borne

Malaria P.f Ag

WB

5 μ l

15-30 mins CE-IVD, WHO PQ

WB: 20 μ l, S/P: 10 μ l

Sensitivity: 97.6% Specificity: 96.9% 5-20 mins

Vector-borne Malaria P.f/P.v Ab

WB/S/P

-

* Venous Whole Blood Sensitivity: P.f 99.59%, P.v 100% Specificity: 100% * Capillary Whold Blood Sensitivity: P.f 99.38%, p.v 100% Specificity: 100% * Venous Whole Blood Sensitivity: P.f 99.58%, P.v, P.m. and P.o. confirmed specimen on pan

Vector-borne Malaria P.f/P.v Ag

WB

5 μ l

15-30 mins CE-IVD, WHO PQ

100% Specificity: 100% * Capillary Whold Blood

Malaria P.f/pan Ag

Vector-borne

WB

5 μ l

15-30 mins CE-IVD, WHO PQ

Sensitivity: P.f 99.68%, P.v, P.m. and P.o. confirmed specimen on Pan 100% Specificity: 100%

WB: Whole Blood. S: Serum. P: Plasma. NP: Nasopharyngeal

Ordering information: USA 5171 Wilfong Road Memphis, Tennessee 38134 Phone: +1 901-382-8716 Fax: +1 901-333-8223

Email: info@meridianlifescience.com Orders: orders@meridianlifescience.com www.meridianbioscience.com/lifescience

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