Sexually Transmitted Diseases (STDs)

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Herpes Simplex Virus Type 1 (HSV-1) & 2 (HSV-2) HSV infections are common worldwide however, the majority of infected individuals remain undiagnosed. HSV-1 is usually transmitted during childhood through contact with oral secretions (cold sores). HSV-2 is the main cause of neonatal HSV infection (70-85%) which can be devastating to an infant and can develop into congenital HSV which has serious consequences including death. Due to a high degree of genetic similarity between HSV-1 and HSV-2, most viral proteins induce a cross- reactive antibody response that hampers the discrimination between HSV-1 and HSV-2 infections using serological approaches. However, since the discovery of the serologically distinct HSV viral envelope glycoproteins gG-1 (HSV-1) and gG-2 (HSV-2), new type-specific immunoassays have been developed that are capable of discriminating between HSV-1 and HSV-2 infections. Specificity Type Catalog # Host / Source Tested Apps Format Isotype HSV-1 Herpes Simplex Virus Type 1 (HSV-1) Antigen (Strain F) >10% Viral Protein Ag 7305 Vero Cells EIA Partially Purified N/A

Partially Purified

Herpes Simplex Virus Type 1 (HSV-1) Antigen (Strain F) Concentrate Herpes Simplex Virus Type 1 (HSV-1) Glycoprotein D Glycosylated, Recombinant Herpes Simplex Virus Type 1 (HSV-1) Glycoprotein G, Recombinant Herpes Simplex Virus Type 1 (HSV-1) Glycoprotein D, Recombinant

N/A

Ag 7309

Vero Cells

EIA

Ag VTI510

CLIA, WB

Purified

IgG2b

Pichia pastoris

Ag VTI520

CLIA, WB

Purified

IgG2b

S. cerevisiae

Ag R18430

EIA, WB

Purified Purified Purified Purified

IgG2b

E. coli

Herpes Simplex Virus Type 1 (HSV-1) Herpes Simplex Virus Type 1 (HSV-1)

MAb C01290M Mouse MAb C01291M Mouse MAb C65141M Mouse MAb C8A020M Mouse MAb C66150M Mouse MAb C65120M Mouse MAb C05014MA Mouse PAb B65131G Goat PAb B65133G Goat PAb B65134G Goat

EIA EIA IFA

IgG2a

IgG3 IgG1 IgG1

Herpes Simplex Virus Type 1 (HSV-1) Glycoprotein C Herpes Simplex Virus Type 1 (HSV-1) Glycoprotein D Herpes Simplex Virus Type 1 (HSV-1) Glycoprotein G-1 Herpes Simplex Virus Type 1 (HSV-1) Glycoprotein E Herpes Simplex Virus Type 1 (HSV-1) Nucleocapsid Protein (155kDa)

EIA, IP, WB Purified

WB

Purified Purified

IgG

EIA, IFA

IgG1 IgG1

IFA, IP, WB Purified

Herpes Simplex Virus Type 1 (HSV-1) Herpes Simplex Virus Type 1 (HSV-1) Herpes Simplex Virus Type 1 (HSV-1)

EIA, IFA EIA, IFA

Purified

N/A N/A N/A

FITC HRP

EIA

HSV-2 Herpes Simplex Virus Type 2 (HSV-2) Antigen (Strain G) >10% Viral Protein Herpes Simplex Virus Type 2 (HSV-2) Antigen (Strain G) Concentrate Herpes Simplex Virus Type 2 (HSV-2) Glycoprotein D, Glycosylated, Recombinant Herpes Simplex Virus Type 2 (HSV-2) Glycoprotein D, Recombinant Herpes Simplex Virus Type 2 (HSV-2) Glycoprotein D (gD) Herpes Simplex Virus Type 2 (HSV-2) Glycoprotein E Herpes Simplex Virus Type 2 (HSV-2) Glycoprotein G (gG-2) Recombinant Herpes Simplex Virus Type 2 (HSV-2) Glycoprotein G (gG) Herpes Simplex Virus Type 2 (HSV-2) Glycoprotein G (gG) Herpes Simplex Virus Type 2 (HSV-2) Glycoprotein G, Recombinant Herpes Simplex Virus Type 2 (HSV-2) Glycoprotein G, Recombinant Herpes Simplex Virus Type 2 (HSV-2) Glycoprotein G Herpes Simplex Virus Type 2 (HSV-2) Glycoprotein G-2 Herpes Simplex Virus Type 2 (HSV-2) Glycoprotein G-2

Partially Purified Partially Purified

N/A

Ag 7705

Vero Cells

EIA

N/A

Ag 7749

Vero Cells

EIA

Ag VTI540

EIA, WB

Purified

IgG2b

P. pastoris

Ag R18530

EIA, WB

Purified Purified Purified Purified Purified Purified Purified Purified Purified Ascites Purified Purified

IgG2b

E. coli

MAb C01859M

Mouse

EIA, IFA

IgG1 IgG1

MAb C65901M Mouse

EIA

EIA, LF, CLIA, WB

N/A N/A N/A

Ag

R01673

E. coli

Ag R01594 Ag R01591 Ag R18350

Synthetic Synthetic

EIA, WB EIA, WB EIA, WB

IgG2b

E. coli

Ag VTI530

EIA, WB

IgG2b

S. cerevisiae

MAb C65116M Mouse MAb C66501M Mouse MAb C66516M Mouse MAb C01292M Mouse

IFA WB WB EIA

IgG1

IgG IgG

Herpes Simplex Virus Type 2 (HSV-2)

IgG1

Sexually Transmitted Diseases (STDs)- Reagents for Assay Development 31

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