Antibody and Antigen Detection Assays Hepatitis C (HCV)
QUICK PRODUCT SELECTION BASED ON HCV GENOME
HCV RNA Region encoding polyprotein precursor
5’NTR
STRUCTURAL PROTEINS
NON-STRUCTURAL PROTEINS
3’NTR
HCV Chimeric (Core/NS3/NS4/NS5) (E. coli) • BN1032 (NS3+ Capsid) • R01599 (a.a. 11-45, 1208-1430, 1885-1923, 2332-2423) • R01600 (a.a. 11-53, 1210-1450, 1337-1483, 1888-1925, 2332-2423) • R18523 (amino acid sequence is proprietary)
C
E1 E2
NS1 NS2
NS3
NS4A NS4B NS5A NS5B
Metalloprotease Serine protease RNA helicase
IFN-resistance protein
Envelope glycoproteins
RNA polymerase
Nucleocapsid
Cofactors
Transmembrane protein
HCV Core MAbs
HCV NS5 Ag (E. coli)
HCV NS3 Ag (E. coli)
• BN1101 • BN1102
• R18206 (genotype 1a, a.a. 2322-2423) • R18190 (genotype 1, a.a. 2212-2313)
• R01518 (genotype 1a, a.a. 1192-1459) • R18800 (genotype 2b, a.a. 1192-1459) • R18358 (genotype 1a, a.a. 1192-1459) • R8A442 (a.a. 1450-1643)
• C65185M (structural) • C8A016M (a.a. 1-80) • C8A216M (a.a. 70-90) • C01253M (1a & 2) • C65317M (a.a. 33-38) • C11423M (a.a. 36-115)
HCV NS4 Ag (E. coli)
HCV Core Ag • BN1031 (genotype 1a, E. coli ) • BN1033 (genotype 1b, E. coli ) • BN1034 (genotype 2a, E. coli ) • BN1035 (genotype 3a, E. coli ) • BN1036 (genotype 4a, E. coli ) • BN1037 (genotype 6a, E. coli ) • VTI710 ( P. pastoris ) • R18140 (genotype 1, E. coli )
• R18541 (mosaic) • R8A116 (genotype 4a+b, a.a. 1658-1863)
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Hepatitis- Reagents for Assay Development
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