Blood Donor Screening

Molecular Reagents Optimized RT-qPCR Master Mix

MDX025 Low LOD 1-Step RT-qPCR Mix Suitable for detecting RNA and DNA viruses at very low levels for applications such as blood bank or transplant viral testing. Novel buffer system optimized for multiplex assays. Perform first-stand DNA synthesis and qPCR in a single tube.

Product Performance Data: Low Limit of Detection (LOD) for both RNA and DNA Viruses

Amplification Curves Amplification Curves HIV-2 (5 IU/mL)

Amplification Curves plification Curves HCV (30 IU/mL) Amplification Curves

23.688 23.079 23.079 23.6 8

40.432

21.688 21.079 21.079 21.6 8

36.932

19.688 19.079 19.079 19.6 8

33.432

17.688 17.079 17.079 17.6 8

29.932

15.688 15.079 15.079 15.6 8

26.432

13.688 13.079 13.079 13.6 8

22.932

11.688 11.079 11.079 1.6 8

19.432

9.688 9.079 9.079 9.6 8

15.932

7.688 7.079 7.079 7.6 8

12.432

5.688 5.079 5.079 3.688 3.079 3.079 3.6 8 1.688 1.079 1.079 1.6 8 5.6 8

8.932

5.432

1.932

2 4 6 8 10 2 4 6 8 10 12

12 12

14 14 20 14

16 16

18 18 26

20 20

22 22

24 24 24

26 26

28 28

30 30

32 32 32

34 34 34

36 36 36

38 38 38

40 40 40

42 42 42

44 44 4

10 4 16

18

22

24

28

22 30 3

34

36

38

40

42

44

2

4

6

8

12

16

18

20

26

28

30

2

4

6

8

10

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4

6

8

10

12

14

16

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22

24

26

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32

34

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38

40

42

44

Cycles

Cycles

Cycles

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Amplification Curves HAV (5 IU/mL) Amplification Curves

Amplification Curves HBV (15 IU/mL) Amplification Curves

23.688

6.628

21.688

6.028

19.688

5.428

17.688

4.828

15.688

4.228

13.688

3.628

11.688

3.028

9.688

2.428

7.688

1.828

5.688

1.228

3.688

0.628

1.688

0.028

2

4

6

8

10

12

14

16

18

20

22

24

26

28

30

32

34

36

38

40

42

44

2

4

6

8

10

12

14

16

18

20

22

24

26

28

30

32

34

36

38

40

42

44

Cycles

Cycles

Cycles

Cycles

B19 (60 IU/mL)

Amplification Curves Amplification Curves HIV-1 (60 IU/mL)

Amplification Curves

Amplification Curves

63.075

43.077

57.075

39.077

35.077

51.075

31.077

45.075

27.077

39.075

23.077

33.075

19.077

27.075

15.077

21.075

11.077

15.075

7.077

9.075

3.077

3.075

2

4

6

8

10

12

14

16

18

20

22

24

26

28

30

32

34

36

38

40

42

44

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44

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Method: 24 replicates of purified blood viral extracts were tested in singleplex qPCR reactions using the Low LOD 1-Step RT-qPCR Mix at the indicated IU/mL. The singleplex reactions were HAV, HBV, HCV, HIV-1, HIV-2, Parvovirus B19. The amplification curve results illustrate that Low LOD 1-Step RT-qPCR Mix can be used with both RNA and DNA viruses as low as 5 IU/mL.

Sequencing Grade dNTPs Ready-to-use sequencing grade dNTPs available individually, as sets, or pre-blended dNTP mixes. Ultra-pure (>99% by HPLC) dNTPs supplied as lithium salts. Free of PCR inhibitors, DNase and RNase. For more information visit www.MeridianLifeScience.com.

Ordering information: USA E: info@meridianlifescience.com Toll free: +1 800 327 6299 UK E: info.uk@meridianlifescience.com Tel: +44 (0)20 8830 5300

Germany E: info.de@meridianlifescience.com Tel: +49 (0)3371 60222 00 Australia E: info.au@meridianlifescience.com Tel: +61 (0)2 9209 4180

美国迈迪安生命科学公司 电子邮件: vivian.li@meridianlifescience.com 电话: +86-159-1103-0750

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