Hormones & Steroids

Luteinizing hormone (LH)

Luteinizing hormone (LH) is a gonadotropic hormone that is produced by the pituitary gland and operates in conjunction with FSH to drive puberty, menstruation and fertility. A surge in LH levels triggers ovulation and the development of the corpus lutem in females, and in males it causes the Leydig cells to release testosterone. LH is composed of two noncovalently associated dissimilar amino acid chains, alpha and beta. The alpha chain is similar to that found in human thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH), and human chorionic gonadotropin (hCG). LH diagnostic assays are useful to evaluate fertility issues, the function of reproductive organs (ovaries or testicles), or to detect ovulation. In children it can also be useful to evaluate early or delayed sexual maturation. The most sensitive LH assays on the market are monoclonal antibody based competitive-ELISAs. However, lateral flow devices using antibody sandwich-based formats are widely used for at-home ovulation tracking.

Reagents for Immunoassay Development


MAb to LH • Cross-reactivity: hCG (<0.01%), FSH (>0.1%) • Capture Antibody


MAb to LH • > 90% pure (SDS-PAGE) • Detection Antibody

Suitable for use in ELISA


MAb to LH • Cross-reactivity: hCG (<0.01%), FSH (>0.1%) • Capture Antibody MAb to LH • > 90% pure (SDS-PAGE) • Detection Antibody



LH > 98% pure • Sourced from human pituitary glands • Activity: 15,600 IU/mg

Suitable as a Control or Calibrator for EIA Assays

• Contaminants (<0.5% w/w): FSH (1 IU/mg), hGH (<0.001 mg/mg), PRL (<0.001 mg/mg), TSH (<0.01 IU/mg) • Lyophilized from 50 mM Ammonium Bicarbonate



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