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用于开发心脏和代谢标志 物体外诊断试剂的原料 ISO认证

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心脏和新陈代谢诊断

心血管和代谢疾病是全球导致死亡的主要原因。一项进取性的诊断和治疗方 法可以从实质上降低死亡和危及生命的并发症的风险。

心血管疾病(CVD)是全世界主要的健康问 题,造成的死亡人数占全世界总死亡人数的三 分之一。它通常通过代谢性疾病分类,因为这 种疾病通常是代谢异常或糖尿病导致的结果。 但是与新血管疾病相关的疾病分类包括冠心 病、脑血管疾病和动脉末梢疾病。 心脏标志物在评估急性冠脉综合症(ACS)患 者风险和提供快速诊断方面尤其有效。心脏标 志物是蛋白质、激素、酶或其他心肌细胞表达 的物质,它们通常通过细胞坏死释放到血液 中。一些诊所日常使用的生物标志物包括肌酸 激酶(CK)、肌酸激酶-MB(CK-MB)、肌红 蛋白、心脏肌钙蛋白T(cTnT)和心脏肌钙蛋 白I(cTnI)。目前肌钙蛋白被认为是心脏损伤 最灵敏和最具特异性的指标。其他有用的标志 物包括NT-proBNP,它有助于预测心律不齐复 发事件升高的风险。

Retrieved 2013: www.cardiac-biomarkers.com

具有潜力的新型标志物正在被不断研发,功能基因组学、蛋白质组学和代谢组学已经取得了进步,生物信息学已经 引发了研发过程的革命。总的来说,与使用单一标志物相比使用一种以上的生物标志物能增加早期预测的价值,技 术的进步将提高多标志物使用的性能,有望在未来提高CVD的治疗效果并实现个体化治疗。 代谢疾病包括正常的新陈代谢被破坏的疾病如糖尿病和血脂蛋白异常(异常脂类代谢)。与生活方式、环境或药物 相关的主要或次要因素可能引发这类疾病。代谢综合征是一种能提高糖尿病、中风和心脏疾病风险的特殊条件的集 合,影响着世界上四分之一的成年人群。在过去的几年中,几个专家组致力于设定4个可用于临床环境鉴别患者是否 患有代谢综合征的诊断指标。这些风险因素包括腰围变大、三酸甘油酯水平升高、高密度脂蛋白胆固醇下降、血压 升高以及空腹血糖升高。由于症状的出现情况外加特殊人群非代谢综合征风险因素不同,风险升高的量级也不同。

用于开发心脏和代谢标志物体外诊断试剂的原料

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产品快速查找清单

L 凝集素氧化LDL受体1 (sLOX) . 可溶型. ............................................16 瘦蛋白............................................16 脂蛋白 HDL, LDL, VLDL 受体.........16 脂蛋白相关磷脂酶 A2 (Lp-PLA2). 16 低密度脂蛋白受体蛋白 (LRP)........17 M 丙二醛 (MDA) . .............................17 单核细胞趋化蛋白 1 . (MCP-1/MCAF)............................17 过氧化物酶(MPO).........................17 肌红蛋白 (MYO). ..........................17 N 神经元特异性烯醇化酶 (NSE).......18 中性粒细胞明胶酶相关脂笼蛋白 (NGAL) / 脂质运载蛋白-2.............18 P 纤维酶原激活物抑制剂 1 (PAI-1). .18 血小板因子IV (PF-IV).....................19 妊娠相关血浆蛋白 A (PAPP-A). ...19 原降钙素 (PCT)..............................19 原骨胶原 II型I.................................20 胰岛素原........................................20

R 松弛素............................................20 肾素................................................20 S S-100 .............................................20 S-腺苷高半胱氨酸 (SAH). ..............21 血清淀粉样蛋白A (SAA)...............21 基质细胞衍生因子1α (SDF-1α).....21 T 凝血酶............................................21 血小板反应蛋白 ............................21 组织纤溶酶原激活物(tPA). ...........21 肌钙蛋白复合物 ............................22 肌钙蛋白C-心脏 (cTnC). ..............22 肌钙蛋白I-心脏 (cTnI)....................22 肌钙蛋白I-骨骼 (sTnI).....................23 肌钙蛋白T-心脏 (cTnT). .................23 肿瘤坏死因子α (TNF-alpha). .......23 U 尿鸟苷素........................................23 V 维生素D.........................................24 血管甲型血友病因子 (VEF)...........24

A 脂联素..............................................8 白蛋白..............................................8 血管紧张素......................................9 载脂蛋白 A & B................................9 载脂蛋白C....................................10 载脂蛋白 E.....................................10 B 脑利钠肽(BNP), ProBNP+. NT-ProBNP.....................................10 C 羧甲基赖氨酸 (CML) ....................11 sCD40 配体(sCD40L). ..................11 I & III型胶原....................................11 C肽和胰岛素原. ............................12 C-反应蛋白 (CRP).........................12 肌酸激酶 BB (CK-BB). ...................12 肌酸激酶MB (CK-MB)...................13 肌酸激酶MM (CK-MM)................13 CX3CR1. .......................................13 血清胱抑素C.................................13 D D-二聚体........................................14 E 内皮型一氧化氮合酶 (eNOS). ......14 内皮素-1. .......................................14 表皮生长因子 (EGF) .....................14 F 脂肪酸结合蛋白(FABP).................14 纤维蛋白原/ 纤维蛋白肽 A. ..........15 G 半乳糖凝集素3. .............................15 胃促生长素....................................15 磷酸化酶同工酶 BB (GPBB)..........15 H 糖化血红蛋白 (HbA1c).................15 I 白介素8 (IL-8). ...............................15

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=公司简介

迈迪安生命科学公司是家大规模生产以下产品的领军制造商: • 抗体

• PCR多聚酶 • 核苷酸 • 体外诊断关键试剂

• 病毒抗原 • 重组蛋白

40年以来,迈迪安生命科学公司始终坚持以提供创新的生命科学解决方案和建立值得信赖的合作伙 伴关系为我们的宗旨。我们的重点是为体外诊断试剂公司提供优质的原料和服务,使其有助于推动 这些领域的发展。

• 具有蛋白质纯化的专业知识基础的各类抗原和抗体的商业化大规模生产 • 包括各类抗原,抗体,及其封闭剂的完整的免疫学诊断试剂产品系列

• 大规模生产的用于分子生物学检测的各种试剂 • 具有开发体外诊断新技术经验的技术支持部门

• 具有专门的研发团队和生产团队 • 具有严格和成熟的质量管理体系

ISO Certified 13485:2016

用于开发心脏和代谢标志物体外诊断试剂的原料

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全面的生产能力和服务

免疫学诊断 • 抗 原及抗体 • 重 组蛋白 • B 阻断剂

分子诊断 • 核 苷酸 • 酶 • 终 点PCR/定量PCR试剂 • 二 代测序 合同定制 • 抗 原及抗体 • 细 胞库及病毒库的建立 • P CR/qPCR检测研发 全球分布

迈迪安生物科学公司 母公司 | 成立于1977年 | 纳斯达克:VIVO 总部位于俄亥俄州辛辛那提 | 750+名员工 | 在70多个国家设有办事处

美国

欧洲

亚太平洋

澳大利亚,悉尼 销售和客户服务

田纳西州, 孟菲斯 病毒抗原 重组蛋白 I体外抗体 PCR 试剂

英国,伦敦 PCR / qPCR 试剂研发 . PCR 试剂生产及销售 德国,卢肯瓦尔德 核苷酸大规模生产各类PCR 酶 法国,巴黎 EU 诊断销售和客户服务 比利时,滑铁卢 EU 诊断销售和客户服务 意大利,米兰 EU 诊断销售和客户服务

中国,北京. 销售和分销. 全资子公司

马萨诸塞州,比尔瑞卡 Magellan, Leadcare 佛罗里达州,博卡拉顿 体外抗体 魁北克,加拿大 GenePOC, 分子诊断

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公司简介

• 3400+产品 •高度特异性&灵敏度 •抗体配对 •大批量

抗原和抗体

传染病 ToRCH • Toxo • Rubella • CMV • HSV-1, 2

童年 • Mumps • Rubeola • EBV

热带 • Nipah • Dengue 1, 2, 3, 4

• Coxsackie • Rotavirus • RSV • Parvo B19 • VZV

• Chikungunya • Mayaro Virus • Malaria • Chagas • Lassa Virus

胃肠道 • Norovirus • Astrovirus • Adenovirus • Rotavirus •  Clostridium difficile •  Cryptosporidium •  Campylobacter •  E. coli •  Salmonella •  Giardia Iamblia

食物和水 • Hepatitis A •  Campylobacter jejuni •  E. coli •  Legionella pneumophila •  Salmonella •  Shigella •  Bacillus anthracis •  Clostridium •  Listeria •  Streptococcus •  Staphylococcus •  Giardia lamblia •  Cryptosporidium

呼吸 • RSV

• Leishmaniasis • Leptospirosis • Newcastle disease • Yellow Fever • Zika • Lyme disease • Ebola

• Influenza A,B • Parainfluenza •  Mycoplasma pneumoniae •  Chlamydia pneumoniae •  Legionella pneumophila •  Mycobacterium tuberculosis •  Streptococcus •  Staphylococcus • SARS Coronavirus • Adenovirus

性病 • HSV-1, 2 • HIV-1, 2 • HPV • Chlamydia • Neisseria • Syphilis

•  H. pylori Hepatitis

• HAV • HBV • HCV • HEV

用于开发心脏和代谢标志物体外诊断试剂的原料

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癌症

心脏的

• PIVKA-II • CA125 • CA15-3 • CA19-9 • CA72-4 • CA50 • CA242 • CEA • Cyfra 21-1 • erbB-2/HER2 • AFP

• Troponin I, T • Myoglobin • BNP • NT-proBNP • CRP • PCT • CK-MB • Apo A,B,E • NSE • FABP • SAH • Galectin-3

• EGFR • HE4 • NSE • P53 • PMA

• Cystatin-C • D-Dimer • MPO • Fibrinogen • EGF • sCD40L • CD54 • Lp-PLA2 • PAPP-A • Vitamin D • Renin

• PAP • PSA

• PSMA • S-100 • B2M • Thyroglobulin

免疫球蛋白/阻滞剂

激素

• TRU Block™ & IgM Diluent • Animal IgGs – Bovine, Chicken, Goat, Mouse, Rabbit, Sheep • Human IgA, IgG, IgM, IgE

• LH, FSH, hCG, hGH • AMH • Cortisol, Estradiol • Insulin, C-peptide • Prolactin • Progesterone • PTH

• PAPP-A • TSH, T4, T3, ACTH • Thyroglobulin

• Kappa Light chain • Lambda Light chain • Goat Anti-Human IgG, IgM, IgA • Goat Anti-Mouse IgG

滥用药物

• Amphetamine • Barbital • Benzodiazepine • Buprenorphine

• Fentanyl • Ketamine • K2 • MDMA (Ecstasy) • Methadone • Methamphetamine • Morphine

• Norketamine • Opium • Oxycodone • PCP • Phenobarbital • Propoxyphene • THC

• Cocaine • Cotinine • EDDP 自身免疫性 • Jo-1 • PCNA

过敏原 • Animal • Dust Mite • Mold • Pollen

• Histone • GMB • C1q • ScI-70 • B2-Gly-1

• pANCA • cANCA • Sm Ag • dsDNA

• Cathepsin G • Calprotectin

• La (SS-B) • Ro (SS-A)

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主要心血管标志物

抗体和配对

脑利钠肽(BNP), ProBNP + NT-ProBNP H86245M

胱抑素C H86023M H86218M H86013M

MAb to BNP ( Capture ), ELISA & WB MAb to BNP ( Detection ), ELISA & WB

MAb (Capture) , ELISA MAb (Detection) , ELISA MAb (Alternate Detection)

H86507M

* Recognizes BNP. H86451M

M Ab to NT-proBNP a.a. 61-76 (Capture) , ELISA & WB M Ab to NT-proBNP a.a. 1-12 (Detection) , ELISA & WB

D-二聚体 N01265M MAb, ELISA

H86912M

N01273M MAb ( Capture ), ELISA & WB N01274M MAb ( Detection ), ELISA & WB N01270M MAb (Capture) , ELISA, LF & WB N01269H MAb (Detection) , ELISA, LF & WB * Highly specific for D-dimer and other cross linked fibrin degradation products containing D-dimer, but no reactivity with Fragment D or E. No cross-reaction was found with purified intact fibrinogen or fibrinogen degradation products. N86304M MAb (Capture) , ELISA & WB N86352M MAb (Detection) , ELISA & WB * Reacts with high molecular weight fibrin degradation products. Does not cross react with fibrinogen or D-monomer.

* Recognizes BNP, proBNP and NT-proBNP. K4A660R

P Ab to BNP (Rabbit) ELISA, RIA, & IHC, lyophilized

H01420M

M Ab to NT-proBNP a.a. 61-76 ( Capture ), ELISA & WB M Ab to NT-proBNP a.a. 15-20 ( Detection ), ELISA & WB M Ab to NT-proBNP a.a. 15-20 ( Alternate Detection ), ELISA & WB M Ab to NT-proBNP a.a. 5-12 (Capture) , ELISA & WB M Ab to NT-proBNP a.a. 22-36 (Detection) , ELISA & WB

H01419M

H01423M

* Detects NT-proBNP and proBNP. H01422M

脂肪酸结合蛋白(FABP) H01324M

MAb (Capture) , ELISA & LF MAb (Detection) , ELISA & LF

H01424M

H01323M

纤维蛋白原 N86413M MAb, ELISA & WB

* Detects NT-proBNP regardless of glycosylation.

C-反应蛋白 (CRP) M86005M MAb (Capture) , ELISA M01239M MAb (Detection) , ELISA * Recognizes antigen in the presence and in the absence of Ca 2+ .

半乳凝素-3 K01361M

MAb, ELISA, WB & IHC

* Reacts with human and mouse Galectin-3. K01381M MAb, ELISA * Reacts with human and mouse Galectin-3. 糖原磷酸化酶同工酶BB (GPBB) H86807M MAb, ELISA & WB 脂蛋白相关磷脂酶A2 (Lp-PLA2) H01390M

肌酸激酶(CK) MAC01-288 MAb to CK-BB, ELISA H31795M

M Ab to CK-MB (Capture/Detection) , ELISA & LF P Ab (Goat) to CK-MM (Capture/Detection) , ELISA & LF

K31315G

* Abs can be used as capture or detection in a sandwich assay. MAC02-186 MAb to CK-MM, ELISA * 50% cross reactivity with CK-MB and < 1% cross reactivity with CK-BB. MAC02-512 MAb to CK-MM, ELISA * 52% cross reactivity with CK-MB, and no cross reactivity with CK-BB.

MAb (Capture) , ELISA MAb (Detection) , ELISA

H01393M H01389M H01392M H01393M

MAb (Alternate Detection) , ELISA

MAb (Capture) , ELISA MAb (Detection) , ELISA

5 | Cardiac & Metabolic Markers for Assay Development 用于开发心脏和代谢标志物体外诊断试剂的原料 5

髓过氧化物酶(MPO) H87207M MAb, ELISA & IHC * Recognizes both native and recombinant human MPO.

肌红蛋白(MYO) H86142M

肌钙蛋白I (cTnI) H86285M

MAb (Capture) , ELISA MAb (Detection) , ELISA

H86703M

M Ab to a.a. 86-90 (Capture) , ELISA &WB

H01347M M Ab to a.a. 24-40 (Detection) , ELISA & WB * Reacts equally with free cTnI and complexed cTnI, does not cross react with sTn. H01340M MAb to a.a. 41-49, ELISA H86241M MAb to a.a. 87-91, ELISA &WB H86596M MAb to a.a. 169-178, ELISA &WB K31015M MAb (Capture) , ELISA K31341G P Ab to a.a. 27-39 (Goat, Detection) , ELISA, WB & IHC K31342G P Ab to a.a. 69-86 (Goat, Alternate Detection) , ELISA & IHC * Cross reactivity with sTn is < 0.1% (ELISA).

H01328M H01327M

MAb (Capture) , ELISA & LF MAb (Detection), ELISA & LF

降钙素原(PCT) E86561M

MAb (Capture) , ELISA & WB MAb (Detection) , ELISA & WB

E86420M

* Specific to procalcitonin and calcitonin. E86412M

MAb (Capture) , ELISA MAb (Detection) , ELISA

E86813M

* Specific for procalcitonin and katacalcin.

妊娠相关血浆蛋白A (PAPP-A) E86141M

肌钙蛋白 T (cTnT) H86429M

MAb (Capture) , ELISA & WB

M Ab to a.a. 60-70 (Capture) , ELISA &WB M Ab to a.a. 95-181 (Detection) , ELISA & WB

E86910M MAb (Detection) , ELISA & WB * Detects both heterotetrameric (found in placental blood) and homodimeric (found in atherosclerotic plaques) PAPP-A. E86114M MAb, ELISA & WB S-腺苷 - 同型半胱氨酸 (SAH) K01395C PAb (Chicken), ELISA * Affinity purified, treated with Adenine-9--D-Ribofuranoside to remove cross reaction to Adenosine.

H86111M

* Does not cross react with sTn.

维生素D K01214M

MAb to Vitamin D (25 OH), ELISA, LF,

CLIA & ELISA * Pairs with antigens A01697B & A01698B. K01213M

MAb to Vitamin D (25 OH), ELISA & RIA

* Pairs with antigens A01697B & A01698B. K24124M-LQ MAb to 25-OH Vitamin D3, ELISA K24124M MAb to 25-OH Vitamin D3, ELISA K24123M MAb to 1,25 (OH) 2 Vitamin D3, ELISA *Recognizes Native Human 25 OH Vitamin D2 and 25 OH Vitamin D3.

可溶性CD40配体(sCD40L) P86106M MAb, ELISA P42374M MAb, FC & IFA

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主要心血管标志物

人体抗原 (用作标准品、质控品和校准品)

脑利钠肽(BNP), ProBNP + NT-ProBNP A24760H P roBNP, recombinant protein (E. coli) of N-terminal (a.a. 1-76, MW 8.39 kDa) A01261H N T-proBNP, recombinant protein (E. coli) of N-terminal (MW 8.589 kDa). Contains an additional methionine residue at the N-terminus (in comparison with native NT-proBNP) N86583H B NP and NT-proBNP Free Plasma, from

纤维蛋白原 A95150H F rom human plasma, MW 340kDa, isoelectric point of 5.1–6.3

Lp-PLA2 A01413H Recombinant (E.coli) ,> 95% pure (SDS-PAGE) 髓过氧化物酶(MPO) A38104H F rom human neutrophils, > 96% pure (SDS-PAGE), approximate activity of 1,100 Units/mg Protein 肌红蛋白 A38131H From human heart, 99% pure (SDS-PAGE)

normal human plasma, used for preparation of any proBNP-related standards and calibrators

A97201H F rom human fluids and reactive with monospecific goat anti-CRP, 95% pure (SDS-PAGE)

妊娠相关血浆蛋白 A (PAPP-A) A86864H F rom human retroplacental blood.

肌酸激酶(CK) VTI830

C K-BB, produced in cell culture (yeast), represents native full length protein and is enzymatically active C K-MB Isoenzyme Type I, produced in cell culture (yeast), enzymatically active C K-MB Isoenzyme Type II, produced in cell culture (yeast), represents native full length protein and is enzymatically active C K-MM Isoenzyme Type I, produced in cell culture (yeast), represents full length protein without the C-terminal lysine on both subunits and is enzymatically active C K-MM Isoenzyme Type III, produced in cell culture (yeast), represents full length protein and is enzymatically active

Heterotetrameric complex consisting of PAPP-A and pro-MBP subunits, > 85% pure (SDS-PAGE), lyophilized

VTI840

降钙素原(PCT) A01367H Recombinant protein (E. coli) representing a.a.

VTI810

3-116 which corresponds to the unprocessed human protein, contains a 6-His tag at N-terminal

VTI850

肌钙蛋白 (cTnT & cTnI) A86111H I-T-C Complex, from human heart, formed by combining cardiac Troponin T, I and C in a molar ratio of 1:1:1 A86813H c TnT, from human heart, > 98% pure (SDS-PAGE) A38150H c TnI, from human heart, > 98% pure (SDS-PAGE), single band ~24 kDa 维生素D A01694D  25-OH Vitamin D3 BSA Conjugate, ≥ 99% Pure (HPLC) A01698B  Vitamin D Biotin Conjugate, > 95.7% Pure (HPLC) A01697B Vitamin D BSA Conjugate A50674H  Vitamin D Binding Protein (Gc-Globulin), > 95% Pure (SDS-PAGE) A01409H 1,25 Dihydroxy Vitamin D3, > 99% Pure (HPLC)

VTI820

胱抑素C A01259H From human urine, 95.5% pure A01435H F rom human urine, 95% pure (SDS-PAGE), major band at ~13 kDa, suitable for TIA applications D-二聚体 A01408H From human plasma, > 90% pure A01463H From human plasma, > 95% pure (SDS-PAGE) 脂肪酸结合蛋白(FABP) A86865H From human heart, > 95% pure (SDS-PAGE)

7 | Cardiac & Metabolic Markers for Assay Development 用于开发心脏和代谢标志物体外诊断试剂的原料 7

产品列表

脂联素 一种在一定程度上调节新陈代谢过程包括血糖管理和脂肪酸氧 化的蛋白质激素。低水平的脂联素与肥胖相关的心血管疾病发 病率的增加有关,如局部缺血性心脏病、外周动脉疾病。 抗体配对 • 适用于ELISA • 体内产生MAb CAPTURE DETECTION H01263M H01262M * Detects total Adiponectin H01286M H01285M * Detects total Adiponectin H01289M H01262M * Detects lowmolecular weight form H01290M H01263M * Detects lowmolecular weight form H01296M H01297M * Detects total Adiponectin H01297M H01296M * Detects total Adiponectin 抗原 A01260H • Native antigen from pooled human plasma • Affinity purified, > 95% pure (SDS-PAGE)

缩略语表 6-His – Polyhistidine-tag

Aff.Pur. – Affinity Purified, analyte-specific column Alk.Phos. – Alkaline Phosphatase conjugated product C. Eggs – Chicken Eggs CLIA – Chemiluminescence Immunoassay CVD – Cardiovascular Disease DB – Dot Blot DFA – Direct Immunofluorescence Assay FC – Flow Cytometry FITC – Fluorescein conjugated product GST – Glutathione S-transferase HRP – Horseradish peroxidase conjugated product IB – Immunoblot

ICC – Immunocytochemistry IEP – Immunoelectrophoresis IFA – Immunofluorescence Assay

白蛋白

IgG – Immunoglobin G IgM – Immunoglobin M IHC – Immunohistochemistry IP – Immunoprecipitation LF – Lateral Flow Lysate – Cells which have been lysed MAb – Monoclonal antibody Monospecific – Single band when tested by immunoelectrophoresis Neat – Whole, unpurified, undiluted antisera Neph – Product has been quality controlled by Nephelometry PAb – Polyclonal antibody Purified/IgG – Refer to the Certificate of Analysis regarding the extent of purification and the purification process used. RIA – Radioimmunoassay RID – Radial Immunodiffusion SDS-PAGE – Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis TIA – Product has been quality controlled by Turbidimetry WB – Western blot

低白蛋白血症是一种身体状况,表现为血液白蛋白水平异常较 低。心脏病患者这种情况很常见,并随着年龄的增加和疾病的深 入更加普遍。它可以作为易发性心衰和晚期肾病和老年患者的独 立预测指标。 单抗 • 在ELSIA内识别人血清白蛋白 • 在体内生成 H86424M 抗体配对 • 适用于ELISA、WB和血清和尿液内人血清白蛋白定量检测 • 不与牛血清白蛋白或蛋白白蛋白反应 • 体内生成MAb CAPTURE DETECTION H86157M H86910M H86157M H86611M 多抗 CATALOG SOURCE FORMAT APPLICATION L01242G Goat Monospecific TIA,Neph,IEP G5P01-0484 Goat Biotin EIA K01263G Goat Monospecific IEP K04301G Goat Monospecific IEP K62110G Goat Monospecific IEP K90032P Sheep HRP EIA 抗原 H8P01-767 • Native antigen from aphoresis plasma • Low B12 and low folate

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多抗 CATALOG

载脂蛋白 A-I (Apo A-I) 载脂蛋白A-I是血浆内高密度脂蛋白(HDL)的主要蛋白成分在 脂类代谢中发挥着重要作用。 单抗 • 不与 Apo A-II或Apo B交叉反应 • 适用于RIA 和 ELISA • 在体内生成 血管紧张书是一种引起导致高血压的血管收缩的肽激素。它是肾 素血管紧张素系统的一部分,是降血压药物的主要目标。血管紧 张素I通过血管紧张素转化酶(ACE)转化为血管紧张素II。ACE 抑制剂广泛用于动脉高血压和心血管疾病的治疗。 单抗 • Suitable for use in ELISA • Produced in vivo E01296M (Angiotensin I) * Does not cross-react with II and III E01297M (Angiotensin II) * Cross-reacts with I and III 抗原 A01310S • Synthetic antigen . (Asn-Arg-Val-Tyr-Val-His-Pro-Phe-OH) • > 98% pure (HPLC), lyophilized 血管紧张素

SOURCE FORMAT

APPLICATION

K04321G Goat K45890G Goat K97211R Rabbit G5C21-766 Goat K34001G Goat K34004G Goat K74001P Goat K45890S

Monospecific IEP

Neat

EIA,WB

Aff.Pur. Aff.Pur. Aff.Pur.

EIA,IB

IEP

EIA,WB EIA,WB EIA,WB

Sheep Neat

Biotin

HRP

EIA,IB

抗原 A50216H

• Native antigen from human plasma HDL • > 95% pure (SDS-PAGE)

载脂蛋白 B (Apo B) Apo B是LDL微粒内主要的载脂蛋白,高水平ApoB以两种主要 的亚型ApoB48和ApoB100出现在血浆内。ApoB48是从小肠到 乳糜唯一的蛋白,ApoB100在肝脏生成的脂蛋白内被发 现。APOB100水平与冠心病有关,是LDL水平较好的预测指标。 单抗 • 适用于ELISA和RIA • 在体内生成

MAC23-031 MAC23-035 H45160M H45161M H45640M H45606M 多抗 CATALOG

MAC20-001 MAC20-029 H45402M H45404M H45625M 多抗 CATALOG

SOURCE FORMAT

APPLICATION

SOURCE FORMAT

APPLICATION

K45252G Goat

Aff.Pur.

EIA,WB EIA,WB

Apo B G5C23-766 Goat K01235G Goat K04323G Goat K62200G Goat Apo B–48/100 K45253G Goat K34003G Goat K34005G Goat

K45252P

Goat

HRP

Aff.Pur.

N/A

K01234G Goat K23600G Goat K04329G Goat

Monospecific IEP

Monospecific IEP Monospecific IEP

Neat

RID

Monospecific IEP

Monospecific EIA,IEP,TIA

K97110S EIA, WB * K04329G & K97110S are specific for ApoA only (not ApoA I) Sheep Aff.Pur.

Aff.Pur.

EIA,WB EIA,WB EIA,WB

Biotin

载脂蛋白 A-II (Apo A-II) Apo A-II是第二丰富的HDL蛋白微粒并在胆固醇逆转运和至;脂 类代谢中发挥着重要作用。它主要在肝脏内生成并调节脂蛋白脂 肪酶和肝甘油三脂酯酶。Apo A-II试验可用作CVD风险评估辅 助试验。

HRP

抗原 A50220H

• Native Apo B100 from human plasma LDL • > 95% pure (SDS-PAGE) and lyophilized • Native Apo B100 from human plasma LDL • Cross-reacts with anti-LDL

A34300H

9 | Cardiac & Metabolic Markers for Assay Development 9 用于开发心脏和代谢标志物体外诊断试剂的原料

载脂蛋白E (ApoE) 极低密度脂蛋白(VLDL)的主要成分,与肝脏特异受体和边缘 细胞结合。具有3种主要等位基因:E3、E4和E2。E3具备正常 功能和正常形态,E2变体与受体的结合能力下降并与高CVD风 险有关,E4变体与LDL胆固醇水平升高和HLD胆固醇水平降低有 关,并与发展为较高的冠心病风险有关。 单抗

载脂蛋白 AI/B (Apo AI/B) 校准品

抗原 A62934H

• Native antigen from human plasma • Apo AI: 313.0 mg/dL (lot dependent) • Apo B: 307.0 mg/dL (lot dependent)

载脂蛋白 CII (Apo CII)

• 与人血浆VLDL反应 • 适用于ELISA和IHC • 体内生成,冻干 H61529M 多抗 CATALOG G5C27-766 Goat K34002G Goat K74190G Goat K62710G Goat

载脂蛋白 CIII 一种调节脂蛋白脂肪酶和卵磷脂胆固醇酰基转移酶的蛋白质, 能引起高甘油三脂血症。血浆脂蛋白Apo CIII水平预测冠心病, 并与代谢综合征有关。 多抗 CATALOG SOURCE FORMAT APPLICATION K74130G Goat Neat EIA,IB K74140G Goat Aff.Pur. EIA,IB K74140P Goat HRP EIA,IB K74170B Goat Biotin EIA,IB K97113R Rabbit Aff.Pur. EIA,IB 抗原 A34129H • Native antigen from human plasma (VLDL) • 95% pure (SDS PAGE) .Apo CII是脂蛋白脂肪酶的辅助因子,这是一种在乳糜内水解甘 油三酸酯的酶,可用作CVD风险评估的辅助试验。 多抗 CATALOG SOURCE FORMAT APPLICATION K74322G Goat Neat EIA,IB K97112R Rabbit Aff.Pur. EIA,IB 抗原 A50302H • Native antigen from human plasma VLDL • 95% pure (SDS-PAGE)

SOURCE FORMAT APPLICATION

Aff.Pur.

N/A

HRP

EIA,WB EIA,WB

Aff.Pur.

Monospecific IEP,TIA

K74180B

Goat

Biotin

EIA,WB

H01378G Goat

Purified

IEP

抗原 A50120H

• Native antigen from human plasma (VLDL) • > 95% pure (SDS-PAGE)

脑利钠肽(BNP), ProBNP+NT-ProBNP BNP(B型钠尿肽)是一种激素而且是对充血性心脏病诊断具有 重要作用的生物标志物。心肌缺血、梗塞和急性肺栓塞中都研究 了它的作用。BNP分泌时,它附着于76氨基酸N端片段—NT- proBNP,具有生物不活跃性。一旦释放,BNP结合到并活化心 钠素(ANP)受体。 单抗 • Reacts with proBNP, N-terminal • Suitable for proBNP and NT-proBNP immunoassay H86705M a.a. 13-27 H86010M a.a. 28-45 *Also works in WB H86916M a.a. 46-60 *Also works in WB H86288M a.a. 61-76

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• NT-proBNP recombinant (E. coli) • > 95% pure (Silver Staining SDS-PAGE) • Suitable for enzyme linked fluorescent assay

R01616

脑利钠肽(BNP), ProBNP+NT-ProBNP 续

抗体配对 • Suitable for use in ELISA and WB • Specific for Human BNP unless otherwise specified CAPTURE DETECTION H86051M H86245M H86051M H86262M

• NT-proBNP recombinant (E. coli) • Suitable for use in ELISA • > 95% pure (Tricine SDS-PAGE)

A01261H

A24607H

• proBNP, N-terminal recombinant (synthetic) • Represents a.a.1-76 • > 95% pure (HPLC), lyophilized • proBNP, N-terminal recombinant (E. coli) • Represents the N-terminal a.a.1-76 • > 95% pure (SDS-PAGE), lyophilized

H86245M H86507M H86245M H86573M H86051M H01365M H01365M H86507M H01365M H86573M H86245M H01255M H01365M H01366M H86051M H86915M H86451M H86912M H86451M H86915M H86511M H86214M H01420M H01422M H86451M H86132M H01420M H01419M H01420M H01423M

A24760H

*Recognizes BNP & pro-BNP *Recognizes BNP & pro-BNP

羧甲基赖氨酸 (CML) 一种已知的糖氧化产物,形成于糖类和脂质氧化,随年龄增长在 组织内积累,CML是一般氧化应激的标志物,与动脉血压与和 的发病机理有关。 多抗 CATALOG SOURCE FORMAT APPLICATION K97135G Goat Aff. Pur. EIA,WB

*Recognizes pro-BNP

*Recognizes proBNP & NT-proBNP *Recognizes proBNP & NT-proBNP *Recognizes proBNP & NT-proBNP *Recognizes proBNP & NT-proBNP *Detects NT-proBNP and proBNP *Detects NT-proBNP and proBNP *Detects NT-proBNP and proBNP

sCD40 配体(sCD40L)

多抗 CATALOG

SOURCE FORMAT APPLICATION

TNF超家族成员主要表达于T细胞。研究表明SCDMA40L可能参与 位于心脏的动脉粥样硬化过程,尤其是在动脉粥样硬化进展炎 症、血栓和再狭窄方面发挥重要作用。 单抗 • Suitable for use in ELISA and WB • Can be used for detection of human sCD40L in serum P86210M

K4A660R Rabbit K4A670R Rabbit

Neat

EIA,IFA,IHC,RIA

Purified EIA,IHC,RIA

K24410R 抗原 R01614

Rabbit

Neat

RIA

• proBNP recombinant (E. coli) • Suitable for enzyme linked fluorescent assay • 95% pure (Silver Staining SDS-PAGE)

I & III型胶原

• proBNP recombinant (E. coli) • > 95% pure (SDS-PAGE)

A24108H

心肌胶原逐步累积出现与每个心脏病病例并在降低心脏功能方 面发挥作用。N端和C端前肽胶原1型和II型是2种主要的心脏胶 原类型并反映胶原形成和降解。它们可作为心肌纤维化诊断的 标志物,正在被研究。 单抗 • Specific for both native and heat denatured human . Collagen Type I • Suitable for ELISA and IHC M1A340M

• proBNP recombinant (E. coli) • Suitable for use in ELISA as a calibrator, . standard or an immunogen for antibody development • Contains one additional Methionine residue at the N-Terminus (in comparison with native proBNP) • > 95% pure (Tricine SDS-PAGE)

A01455H

A24810H

• proBNP, C-terminal (synthetic) • Represents amino acids 1-32 • > 95% pure (HPLC), lyophilized

11 | Cardiac & Metabolic Markers for Assay Development 用于开发心脏和代谢标志物体外诊断试剂的原料 11

单抗 • Recognizes CRP with or without the presence of Ca 2+ • Suitable for use in ELISA • Produced in vivo M01238M * Can also be used in IHC and WB

I & III型胶原续

多抗 CATALOG

SOURCE FORMAT APPLICATION

Collagen Type I T33131G Goat

M66112M M66113M M86007M M86842B

Aff.Pur.

EIA,IB,ICC,IHC

Collagen Type III T40233R

* Can also be used in IHC

Rabbit

Purified EIA,IFA,IHC

* Biotin conjugated

M86842M • Recognizes CRP. • Suitable for use in ELISA (Unless otherwise specified) • Produced in vivo M01319B * Biotin conjugated

抗原 A33123H

• Native Human Collagen Type III • Sourced from placental villi, > 90% pure (SDS-PAGE) • Suitable as a immunoassay standard and for antibody production

M01319M M01295M 多抗 CATALOG

* No applications have been tested

C肽和胰岛素原

C肽是一种氨基酸结合物,是胰岛素的副产品,它的水平通常表 示胰腺生成胰岛素的量。研究显示血清C肽水平与没有糖尿病成 年患者的心血管相关疾病以及冠脉相关死亡事件有关。 单抗 • Reacts with human free C-peptide and Proinsulin • Suitable for use in ELISA and RIA • Produced in vivo

SOURCE FORMAT APPLICATION

L01237G Goat L01238G Goat

Purified Purified

IEP IEP

M01333C C. Egg Aff. Pur.

N/A

抗原 A01430H

• Native antigen from human fluids • 98% pure (SDS-PAGE) • Native antigen from human fluids • 95% pure (SDS-PAGE, Non-Reduced) • Suitable for use in IEP and RID

E01336M E86588M • Reacts with C-peptide • Suitable for use in ELISA and RIA E86710M MHP18-601 MHP18-6014 * Biotin conjugated

A97201H

• Recombinant (E. coli) • Pentamer structure

A01250H

肌酸激酶 BB (CK-BB) CK-BB主要发现与脑部,脑部损伤、脑膜炎、异常细胞增殖、严 重震荡、中风、低体温症、肠道血流受限后,反应为水平上升。 用于肌酸激酶检测,测定心肌损伤生成总肌酸激酶百分比。 单抗 • Produced in vivo MAC01-288 抗原 VTI830 • Recombinant (P. pastoris) • Full length protein with amino acid sequence identical to the native enzyme • > 95% pure (SDS-PAGE) • Suitable for use in ELISA H6C01-323 • Native antigen from human brain • Activity: 730 Units/mL at 37ºC (lot dependent)

C-反应蛋白 (CRP)

CRP主要用作炎症标志物。高敏CRP试验可用于检测CVD、心 脏病和中风的风险。 抗体配对 • Suitable for use in ELISA, high sensitivity • MAbs produced in vivo CAPTURE DETECTION M86005M M01239M * Recognizes CRP with or without Ca2+. M01243M M01239M * Recognizes CRP with or without Ca2+. M01331M M01330M

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抗原 VTI850

肌酸激酶MB (CK-MB)

• Recombinant (P. pastoris), Isoenzyme Type I • Full length protein without the C-terminal lysine on both subunits • Suitable for use in WB and ELISA • Recombinant (P. pastoris) , Isoenzyme Type I • Identical amino acid sequence to . native protein • Suitable for use in ELISA • Native antigen from human skeletal muscle • > 95% pure (SDS-PAGE) • Native antigen from human heart, lyophilized

CK-MB表达在心肌内,它用于急性心梗和可能的心肌再梗死的 诊断。血液循环中的CK-MB的半衰期相对较短(大约12小时) 。CK-MB相对具有心脏特异性,即使健康人群的血液中也含有 低浓度的CK-MB同工酶。 单抗 • Suitable for use in ELISA and LF • Produced in vivo

VTI820

H01298M H01299M 抗体配对 • Suitable for use in ELISA and LF • MAbs produced in vivo CAPTURE DETECTION H31795M K31315G

A31315H

A38925H

CX3CR1

.趋化因子受体,一种新型膜结合趋化因子,主要表达于心梗和心 衰内皮细胞。与CX3CR1结合时,趋化因子作为黏附分子并能黏 附白细胞。炎症条件下这种结合形式能裂解并释放可溶的予以部 分疾病状态有关的趋化因子,包括动脉粥样硬化、肾小球肾炎和 脑部缺血。 多抗 CATALOG SOURCE FORMAT APPLICATION K88201R Rabbit Aff.Pur. IHC,WB * Extracellular Loop V28 K88093R Rabbit Aff.Pur. FC,IHC(p),WB * N-Terminal V28

* K31315G is a polyclonal Goat anti-CK-MM * K31315G is a polyclonal Goat anti-CK-MM

K31315G H31795M H01330M H01329M 抗原 VTI840

• Recombinant (P. pastoris) , Isoenzyme Type I • Suitable for use in ELISA • Recombinant (P. pastoris) , Isoenzyme Type I • Suitable for use in ELISA

VTI810

肌酸激酶MM (CK-MM)

血清胱抑素C

发现于骨骼肌和心脏。如果发生心肌损伤、脑损伤或骨骼碰撞损 伤、癫痫、肌肉萎缩症、肌肉炎症或其他骨骼肌疾病后,CK- MM水平升高。用于肌酸激酶检测,测定心肌损伤生成总肌酸激 酶百分比。 单抗 • Suitable for use in ELISA • Produced in vivo

传统用作肾功能生物标志物,最近被研究用于预测CVD的出现或 恶化。在不同的心血管条件下,血清胱抑素C是敏感的肾功能不 全标志物,是心衰发展的预测指标,并单独与后续CVD和预后有 关。 抗体配对

• Suitable for use in ELISA • MAbs produced in vivo CAPTURE DETECTION H86023M H86013M 多抗 CATALOG

• 52% cross-reactivity to CK-MB • 0% Cross-reactivity to CK-BB

MAC02-186 MAC02-512 多抗 CATALOG

SOURCE FORMAT APPLICATION

SOURCE FORMAT

APPLICATION

H01371C C. Egg Aff.Pur.

N/A

G5C02-766 Goat H01310G Goat K31315G Goat

Aff.Pur. Purified Aff.Pur.

N/A N/A

抗原 A01259H

• Native antigen from human urine • 95.5% Pure • Native antigen from human urine

EIA,LF

* K31315G pairs with MAb to CK-MB H31795M

A01419H

13 | Cardiac & Metabolic Markers for Assay Development 用于开发心脏和代谢标志物体外诊断试剂的原料 13

D-二聚体 D-Dimer是纤维蛋白转化的标志物,水平升高说明存在凝块,这 一结果在深静脉血栓、肺栓塞、浸染血管内凝血、急性主动脉剥 离、心梗、恶性病、产科并发症、妊娠3月和手术中均有报告。它 是急性早期冠脉综合症诊断的标志物可用于传统心梗的评估。 单抗 • Does not cross-react with fibrinogen and D-monomer (unless noted otherwise) • Suitable for use in ELISA and WB N86925M * Reacts with highmolecular weight fibrin degradation products N86925B * Biotin conjugated 抗体配对 • Suitable for use in ELISA and WB • Reactive with D-Dimer and other fribin . degradation products • MAbs produced in vivo CAPTURE DETECTION N01270M N01269H * Does not cross-react Fragment D or E, also suitable for LF N01273M N01274M * Does not cross-react with Fibrinogen

内皮素-1 内皮素1由内皮对血管紧张素II、炎症介质和血管剪切压力反应形 成,这种蛋白对血管收缩、活性氧活化和血管再成型负责。临床 试验证明内皮素拮抗剂对于患有原发高血压、肺高血压和心衰的 患者具有潜在的益处。 单抗 • Suitable for IRMA assays and IHC on frozen sections • Specific for Endothelin ET-1 • Produced in cell culture H54085M 表皮生长因子 (EGF) EGF具备用作心脏标志物的潜力,因为它可以在心脏肝细胞内增 殖。研究表明人类心脏具有心脏干细胞(CSC)储备,可以被多 种生长因子活化重建受损心肌。EGF能联合其他生长因子活化 CSC显著促进增殖、迁移和损伤恢复。 抗原 VTI880 • Recombinant (P. pastoris)

• Suitable for use in WB • >95% pure (SDS-PAGE)

N86304M N86925M N86304M N86043M 多抗 CATALOG H01371C C. Egg

A42115H

• Recombinant (E. coli) • >98%pure (RP-HPLCand SDS-PAGE), lyphilized

SOURCE FORMAT APPLICATION

脂肪酸结合蛋白(FABP) 心脏型FABP是一种小型包浆蛋白(15kDa),它因缺血从心肌 细胞中释放。它是心梗早期标志物可在急性冠脉综合症发生1-3 小时内检测。 抗体配对

Aff.Pur.

N/A

抗原 A01408H

• Native antigen from human plasma • > 90% pure (SDS-PAGE and gel-scanning) • Native antigen from human plasma • Suitable for ELFA • 95% pure (SDS-PAGE) • Native antigen from human plasma • > 90% pure (SDS-PAGE and gel-scanning), lyophilized

A01463H

• Suitable for use in ELISA • MAbs produced in vivo CAPTURE DETECTION H86101M H86505M H01314M H86101M H01314M H01315M H01324M H01323M

A86870H

一氧化氮合酶是L精氨酸酶催化一氧化氮的产物。eNOS仅仅在血 管内生成NO,作为血管防护因子能使内皮细胞抵抗血管疾病。 在存在心血管风险因子如高血压、高胆固醇、糖尿病或慢性吸烟 患者中,活性氧的生成刺激血管壁导致eNOS降解和CVD。 单抗 • Specifically recognizes eNOS phosphorylated at . serine 1177 • Suitable for EIA and WB • Produced in vivo Q67250M 内皮型一氧化氮合酶 (eNOS)

* Also works in LF assays

抗原 A86865H

• Native antigen from human heart • Suitable for use as a immunoassay standard, immunogen for antisera production, or a tracer for iodination • > 95% pure (10-20% gradient SDS-PAGE) • FABP3 Recombinant (E.coli) • Suitable for use in ELISA • 95% pure (silver staining SDS-PAGE)

R01617

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纤维蛋白原/ 纤维蛋白肽 A 纤维蛋白原是一种血浆糖蛋白,是凝血的关键成分,通过丛化血 管内血小板,具有促进血酸凝块形成的能力。一些研究显示纤维 蛋白原水平升高是冠心病的主要风险因素。 抗体配对 • Suitable for use in ELISA • For specific fibrinogen detection, pair a capture . anti-fibrinopeptide A antibody with a detection . anti-fibrinogen antibody • MAbs produced in vivo CAPTURE DETECTION N86710M N86413M * N86710M is specific for Fibrinopeptide A 多抗 CATALOG SOURCE FORMAT APPLICATION

磷酸化酶同工酶 BB (GPBB) GPBB是一种磷酸化酶的同工酶,是肝糖分解的关键酶。研究表 明它可以作为急性心梗和不稳定心绞痛的早期标志物。 单抗 • Suitable for use in ELISA and WB • Produced in vivo H86807M 糖化血红蛋白 (HbA1c) 由于血糖在血液中循环,其中一些自然与血红蛋白结合形成糖化 血红蛋白。特定糖尿病并发症的发展与糖化血红蛋白有关,主要 用于慢性糖血症的测量。 单抗

• Suitable for use in sandwich ELISA • Does not cross-react with HbA10 • Produced in vivo H01331M

K01394C C. Eggs

Aff.Pur.

N/A

抗原 A95150H

* Can also work in indirect ELISA (antigen capture)

• Native antigen from human plasma • Isoelectric point: 5.1 - 6.3

H01388M

* Can also work in WB

抗体配对 • Suitable for use in ELISA • MAbs produced in vivo CAPTURE DETECTION H01291M H01292M H01367M H01369M H01367M H01368M

半乳糖凝集素3

半乳糖凝集素3是一种半乳糖苷结合蛋白G,能结合并活化受损 心脏组织内的肌成纤维细胞,导致胶原合成和后续有为题的纤维 化。它与冠心病患者病情恶化有关,2010年FDA首次批准半乳 糖凝集素3作为标志物试验。 单抗 K01361M *Suitable for use in WB,IHC,IP and ICC, produced in vivo K01381M *Suitable for use in FC, produced in vivo K01382M *Suitable for use in FC, produced in cell culture 抗原 A01421H • Recombinant (E.coli) • 95% pure (SDS-PAGE)

* H01291M is an MAb to hemoglobin * H01367M is an MAb to hemoglobin * H01367M is an MAb to hemoglobin

抗原 A01273H

• Native antigen from human erythrocytes • > 96% HbAlc (HPLC analysis using a . Mono S Column)

白介素8 (IL-8) IL-8是巨噬细胞、淋巴球、上皮细胞和内皮细胞生成的嗜中性趋 化因子,促进中性粒细胞趋化性。CAD患者的研究表明IL-8能预 测心血管事件,独立于其他细胞因子和高敏CRP。 单抗 • Recognizes both recombinant and native human IL-8 • Does not cross-react with human Monocyte Chemotactic Activating Factor (MCAF) or RANTES • Suitable for use in ELISA, WB and neutralizing assays P14670M

胃促生长素

临床研究显示胃促生长素在CHF治疗中发挥重要作用。胃促生长 素已知的心血管效果包括降低血管水平外周阻力,和/或调节交 感神经紧张活性。胃促生长素还具有作为心衰异常代谢机制标志 物的潜力。 单抗 • Suitable for use in ELISA • Produced in vivo E86621M

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抗原 A94005H

白介素8 (IL-8) 续 抗原 A42280H

• Native HDL from human plasma • > 95% of total lipoprotein content by electrophoresis • Native HDL from human normolipidemic plasma • Devoid of VLDL, IDL and LDL • Ultracentrifugation at density 1.063–1.210 • Native HDL 2 (HDL2) Subfraction from human normolipidemic plasma • Devoid of VLDL, IDL, LDL, and HDL3 • Ultracentrifugation density at 1.063 - 1.125 • Native HDL 3 (HDL3) Subfraction from human normolipidemic plasma • Devoid of VLDL, IDL, LDL, and HDL2 • Ultracentrifugation density at 1.120–1.21g/mL • Reconstituted HDL from human plasma • A complex of human Apolipoprotein A-I and 1-palmitoyl-2-oleoyl phosphatidylcholine prepared at a molar ratio of 1 to 100 by the cholate removal method • Native LDL from human plasma • > 95% pure (total lipoprotein content by electrophoresis) • Suitable for use in IEP • Native VLDL from human plasma • Devoid of IDL, LDL, and HDL • Purification by ultracentrifugation at . density 1.006 • Native VLDL from human plasma • > 95% of total lipoprotein content (SDS-PAGE) • Suitable for use in ELISA and IEP

• Recombinant (E. coli), a.a. 1-72 • > 98% pure (HPLC, FPLC and reducing and non-reducing SDS-PAGE)

A95132H

• Recombinant (E. coli) , a.a. 1-77 • > 98% pure (HPLP and SDS-PAGE)

A42208H

A95322H

凝集素氧化LDL受体1 (sLOX) 可溶型

一种氧化低密度脂蛋白主要的内皮受体,在动脉粥样硬化中发挥 作用。动脉粥样硬化前的环境引起表达,包括高血压、高血脂和 糖尿病,它在粥样硬化损伤中累积,与斑块破裂关系密切。尤其 是sLOX-1水平在急性冠脉综合症早期阶段升高,表明其可以作 为急性冠脉综合症的早期诊断标志物。 单抗 • Specific for human recombinant sLOX-1 (a.a. 58-273) • Suitable for use in ELISA and WB • Produced in vivo H86922M

A95332H

A34275H

A95124H

瘦蛋白

一种16kDa蛋白激素,在调节能量摄入和能量消耗中发挥重要作 用,包括食欲/饥饿和新陈代谢。瘦蛋白在肥胖和心血管栓塞之 间发挥纽带作用。血清瘦蛋白浓度与都中心血管风险有关,包括 中风、慢性心衰和心梗。 抗原 A42327H • Recombinant (E. coli) • > 95% pure (RP-HPLC and SDS-PAGE) 脂蛋白 HDL, LDL, VLDL 受体 脂蛋白诊断如LDL胆固醇和HDL胆固醇诊断血脂异常是重要的心 血管疾病和II型糖尿病的风险因素。 单抗 • MAb to LDL Receptor • Recognizes an epitope in the region of repeat #1 of the ligand binding region • Suitable for WB, FC, IFA H44070M • MAb to LDL Receptor-Related Protein (LRP) • Will not block ligand binding • Suitable for use in ELISA, WB, IHC, and FC H63650M

A34013H

A50261H

脂蛋白相关磷脂酶 A2 (Lp-PLA2) Lp-PLA2是一种炎症细胞产生的蛋白,主要和LDL一起循环并造 成LDL氧化磷脂质水解。它能大幅增加动脉粥样硬化斑块并直接 参与动脉粥样硬化的发展和斑块破裂。 单抗

• Suitable for use in ELISA • Produced in cell culture H01389M

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脂蛋白相关磷脂酶 A2 (Lp-PLA2) 续

单核细胞趋化蛋白 1 (MCP-1/MCAF)

过氧化物酶(MPO) MPO是一种过氧化物酶以及剧烈运动期间炎症和中性粒细胞活 化的标志物。此外,它与包含LDL的脂质氧化、巨噬细胞和中性 粒细胞渗透、不稳定冠脉斑块形成以及斑块破裂有关。MPO早 冠脉疾病患者体内升高,并作为预后标志物鉴别形成微脉管障碍 前具有不稳定斑块的患者。 单抗 • Suitable for use in ELISA • Produced in vivo (unless stated otherwise) H87207M *Also works in WB, IHC, FC and produced in cell culture K86005M *Also works in WB MCP1是一种巨噬细胞、平滑肌细胞和动脉粥样硬化斑块内皮细 胞生成的细胞因子,是动脉粥样硬化斑块的重要指标。尤其是, 高水平的MCP-1与较差的预后和死亡风险增加有关,独立于其他 ACS患者的风险因素。 抗原 A01251H • Recombinant (E. coli) • Non-glycosylated polypeptide chain . containing 76 a.a. • > 98% pure (RP-HPLC and SDS-PAGE), lyophilized

抗体配对 • Suitable for use in ELISA • Produced in cell culture CAPTURE DETECTION H01390M H01393M H01390M H01389M H01392M H01393M 多抗 CATALOG

SOURCE FORMAT APPLICATION

H01332S H01333S 抗原 A01413H

Sheep Sheep

Purified Aff.Pur.

EIA,IHC,WB EIA,IHC,WB

• Recombinant (E. coli) • > 95% pure (SDS-PAGE) • Contains a His-tag

A62924H

• Lp(a) Calibrator • Sourced from defibrinated human plasma • Suitable for use in Turbidimetry

低密度脂蛋白受体蛋白 (LRP) LRP是大型多功能受体,清除多种配体空隙,包括选定的脂蛋 白、多种蛋白酶抑制剂复合物以及血小板反应蛋白。LRP鉴别配 体范围表明它在配体过程发挥作用包括代谢、细胞增殖、迁移和 组织侵入。 单抗 • Suitable for use in WB, IHC, and FC • Produced in vivo H63180M * Specifically reacts with the 515 kDa alpha-chain of human LRP/alpha2 H63080M * Specific for human light chain of LRP, 85 kDa 丙二醛 (MDA) MDA是一种多元不饱和脂肪降解形成的反应醛,导致LDL氧化 修饰形成丙二醛低密度脂蛋白(MDA-LDL)。MDA-LDL是不稳 定心绞痛和急性心梗ACS患者敏感的标志物。MDA-LDL不仅可 以作为氧化应激标志物还可以作为斑块不稳定标志物。 多抗 CATALOG SOURCE FORMAT APPLICATION K97120G Goat Neat, Lyophilized EIA,WB K97120P Goat HRP, Lyophilized EIA,WB

K86006M K86016M 多抗 CATALOG

*Also works in WB

SOURCE FORMAT APPLICATION

K50891R Rabbit

Purified

EIA,IEP,WB

抗原 A01462H

• Native antigen from human neutrophils • Suitable for use in ELISA • Native antigen from human neutrophils • > 96% pure (SDS-PAGE) • Native antigen from human neutrophils • 95% pure (SDS-PAGE), lyophilized

A38104H

A50181H

肌红蛋白 (MYO) 肌红蛋白是主要的肌肉组织载氧色素,肌肉损伤时如心脏病 后,在血清内呈现高水平。肌红蛋白达到其最大诊断灵敏度是 在症状出现5小时内,它是心梗的早期标志物。但是,患者并发 创伤或肾衰时,特异性较差。

17 | Cardiac & Metabolic Markers for Assay Development 用于开发心脏和代谢标志物体外诊断试剂的原料 17

• Recombinant (E. coli) , a.a. 2-434 • > 95% pure (SDS-PAGE) • Suitable for use in ELISA, LF, WB, DB and IHC

A01359H

肌红蛋白 (MYO) 续 抗体配对 • Suitable for use in ELISA • MAbs produced in vivo (unless noted otherwise) CAPTURE DETECTION H31572M K31015G * K31015G is a polyclonal (goat)

A01448H • Recombinant (E. coli) , a.a. 1-434 • 95% pure (SDS-PAGE) • Suitable for use in ELISA 中性粒细胞明胶酶相关脂笼蛋白 (NGAL) . / 脂质运载蛋白-2

H86142M H86703M H31927M K31015G H01328M H01327M H86703M H86142M 多抗 CATALOG H01370C C. Eggs K31015G Goat

* H31927 is produced in cell culture

* Also works in LF

一种参与调解细胞凋亡和在细胞膜间运输铁质的糖蛋白。最近发 现其通过影响MMP-9与动脉粥样硬化有关。它是血管再造和斑 块稳固的重要媒介,NGAL水平在存在动脉粥样硬化斑块患者和 心梗患者体内升高。 多抗 CATALOG SOURCE FORMAT APPLICATION K01392C C. Eggs Aff.Pur. N/A

SOURCE FORMAT APPLICATION

Aff.Pur. Aff.Pur.

N/A

EIA

抗原 A38131H

• Native antigen from human heart tissue • 99% pure (SDS-PAGE, reduced) • Native antigen from human heart tissue • > 95% pure (SDS-PAGE), lyohphilized • Suitable for use as a reference or standard in immunoassays • Recombinant (P. pastoris) • > 90% pure (determined by SDS-PAGE) • Suitable for use in ELISA and WB

抗原 9278

• Recombinant (CHO cells) • 95% pure (SDS-PAGE) • Suitable for use in WB 纤维酶原激活物抑制剂 1 (PAI-1)

A86850H

A01428H

PAI-1是组织纤维酶原激活物、尿激酶纤维蛋白溶酶原激活剂的主 要抑制剂。Pain-1水平使患者有形成动脉粥样硬化斑块的倾向。 临床证据表明PAI-1水平升高与动脉粥样硬化有关,PAI-1水平升 高可以作为心梗的预测指标。 单抗 • Recognizes both free and complexed forms of . Human PAI-1 • Suitable for use in ELISA • Produced in vivo N63913M 多抗 CATALOG SOURCE FORMAT APPLICATION K63132R Rabbit Purified EIA,IHC,WB 抗原 A63625M • Recombinant (E. coli) • >95% pure (SDS-PAGE), 80 ± 5% active by uPA titration

神经元特异性烯醇化酶 (NSE) NSE是三种烯醇化酶鉴别型之一,是一种糖酵解酶。研究表明 NSE浓度在缺血性中风后在脑脊液内升高。 抗体配对 • Specific for the gamma subunit without detectable cross-reactivity with the alpha or beta subunits

• Suitable for use in ELISA • MAbs produced in vivo CAPTURE DETECTION M86520M M86101M M86406M M86101M M86416M M86101M M86141M M86201M M86101M M86520M 抗原 A86803H

• Native antigen from human brain • > 95% pure (SDS-PAGE) • Suitable for use in ELISA and WB

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原降钙素 (PCT) 原降钙素是一种激素降钙素肽前体,作为急性炎症诊断标志物很 有前景。尤其是它与早期动脉粥样硬化和细菌感染的炎症标志物 有关。 单抗 • Suitable for use in ELISA and WB (unless otherwise noted) • Produced in vivo E01308M * Biotin conjugated E86131M * Also detects calcitonin 抗体配对 • Suitable for use in ELISA and WB • MAbs produced in vivo CAPTURE DETECTION

妊娠相关血浆蛋白 A (PAPP-A) PAPP-A是高分子量锌结合金素蛋白酶,与易损斑块有关,可能预 测CVD和死亡事件。人体PAPP-A抗原从胎盘血获得,是一种杂 四聚物复合物,包括2种PAPP-A子单位和2种proMBP子单位。从 粥样硬化斑块纯化的人PAPP-A抗原是一种同型二聚体,包括2种 PAPP-A子单位。 单抗 • Detects heterotetrameric PAPP-A (htPAPPA), unless . noted otherwise E86509M E86509M E01261M 抗体配对 • Detects heterotetrameric PAPP-A (htPAPPA), unless . noted otherwise • Suitable for use in ELISA • MAbs produced in vivo 血小板因子IV (PF-IV) PF-IV是隶属于CxC趋化因子家族的小型细胞因子,在损伤修复 和炎症中发挥着重要作用。最近的研究证明它可以作为急性MI患 者血小板活化的标志物。 抗原 A95841H • Native antigen from supernatant of thrombin-activated platelets (human) • > 95% pure (SDS-PAGE)

E86561M E86494M E86561M E86420M E86813M E86112M E01291M E86494M E01330M E01331M E01341M E01340M E01342M E01340M E86412M E86813M E86813M E86112M E01342M E01340M

* Also works in LF assays * Also detects katacalcin * Also detects katacalcin * Also detects katacalcin and works in LF assays

抗原 A01454H

• Recombinant (E. coli) • Represents a.a. 1-116, contains no tags

• Suitable for use in ELISA • MAbs produced in vivo CAPTURE DETECTION E86509M E01261M E86141M E86910M E01345M E01344M E01343M E01261M

• > 95% pure, lyophilized • Suitable for use in ELISA

• Recombinant (E. coli) • Represents a.a. 3-116, contains a His-tag • > 95% pure (SDS-PAGE) • Suitable for use in ELISA and WB

A01367H

* Pair also detects dimeric PAPP-A * Pair detects dimeric PAPP-A only * Pair detects dimeric PAPP-A only

抗原 A86864H

• Native antigen sourced from pooled human retroplacental blood • Specific for heterotrimeric complex (PAPP-A and pro-MBP subunits) • Suitable for use in IFA • > 85% pure (SDS-PAGE), lyophilized • Recombinant (human cell line) • Specific for homodimeric form (dPAPP-A) • Suitable for use as a standard in ELISA or for antibody production • > 90% pure (SDS-PAGE)

A01684H

19 | Cardiac & Metabolic Markers for Assay Development 用于开发心脏和代谢标志物体外诊断试剂的原料 19

原骨胶原 II型I 原骨胶原III型是骨胶原III型—一种结缔组织如皮肤、肺、子宫和 血管系统内发现的纤维胶原的前体分子,通常与I型胶原有关。 该物质血清水平升高与动脉粥样硬化有关。 多抗 CATALOG SOURCE FORMAT APPLICATION T40331R Rabbit Purified EIA,IFA,IHC,RIA

肾素 肾素是由肾脏释放的酶,属于肾素 - 血管紧张素系统的一部分, 肾素 - 血管紧张素系统是一组相互作用的调节血压的激素。. 肾素测定是一种血液测试以发现高血压的诱因。它通常与醛固酮 (由肾上腺制成的激素)一起进行测试,以完全了解个体的激素 水平。 抗体配对

• Suitable for use in ELISA • Produced in cell culture CAPTURE DETECTION E01363M E01364M E01365M E01363M E01365M E01364M E01366M E01364M E01366M E01363M

胰岛素原

胰岛素原始胰岛素的激素原前体。在晚期II性糖尿病中,胰岛素 原与胰岛素分子分泌,和胰岛素的量同时增加。研究显示升高的 完整胰岛素原似乎表明β细胞消耗阶段的晚期,它还是胰岛素抗 药性的高特异性标志物。 单抗 • Does not cross react with human C-peptide

S-100 S-100蛋白家族参与细胞过程的调节包括细胞周期进程和分化。研 究显示S100-beta血清测量可能有助于急性中风的诊断和预后。 单抗 • Produced in vivo MEM24-211 * Works in IHC Q86403M * Recognizes S-100 (beta-beta) and S-100 (alpha-beta), . works in WB 抗体配对 • Suitable for use in ELISA and IP • MAbs produced in vivo CAPTURE DETECTION Q86006M Q86610M * Specific for S-100 beta-beta and alpha-beta Q86003M Q86610M * Specific for S-100 beta-beta and alpha-beta 抗原 A86809H • Native antigen from human brain • Contains beta-beta homodimer (S-100b) and alpha-beta heterodimer (S-100a) • > 95% pure, lyophilized • Suitable for ELISA, as an immunogen for antiserum production and tracer for iodination A86289H • Native S-100b from human brain • > 95% pure, lyophilized • Suitable for ELISA, as an immunogen for antiserum production and tracer for iodination

• Suitable for use in ELISA • MAbs produced in vivo E83802M • Does not cross react with human C-peptide

• Suitable for use in ELISA • MAbs produced in vivo • Recognizes human insulin

E83102M 抗体配对 • Does not cross react with human C-peptide

• Suitable for use in ELISA • MAbs produced in vivo CAPTURE DETECTION E86209M E86102M E86104M E86210M E01339M E83102M E01339M E86802M

* E86102M recognizes human insulin

* E83102M recognizes human insulin

松弛素

松弛素是一种肽激素,在生殖和非生殖器官中发挥不同的作用。 最近的研究发现松弛素水平在心衰时升高并与该疾病的严重性有 关。松弛素还被认为是一种治疗急性心衰患者的药理学药物。 单抗 • Suitable for use in ELISA and FC • Produced in cell culture E24520M * Specific for Relaxin 1 and does not cross-react with Relaxin 2 E24720M * Recognizes Relaxin 1 and 2

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凝血酶 凝血酶是一种具有促凝血、促炎和粗凋亡效果的多功能蛋白 酶。凝血酶可能会对内皮和心肌细胞产生不利影响,它可能是缺 血再灌注损伤的中介物。 单抗

S-腺苷高半胱氨酸 (SAH) SAH通过S腺苷-L蛋氨酸(SAM)脱甲基形成,作为半胱氨酸和 腺苷生成的中间阶段。CVD患者的SAH升高,该物质作为多种 血管功能紊乱疾病的指标。 多抗 CATALOG SOURCE FORMAT APPLICATION K01395C C. Eggs Aff.Pur. N/A 血清淀粉样蛋白A (SAA) SAA是一种敏感的急性炎症标志物,与一些慢性炎症疾病如淀粉 样变性、动脉粥样硬化和类风湿性关节炎有关。全身性炎症(高 SAA水平)可能促进动脉粥样硬化斑块不稳定,此外还能直接导 致动脉粥样硬化形成。 抗体配对 • Suitable for use in ELISA and WB • Recognizes native and recombinant human SAA • MAbs produced in vivo CAPTURE DETECTION H01381M H01383M H01382M H01384M

• Suitable for use in ELISA • Produced in cell culture N95905M

血小板反应蛋白 血小板反应蛋白属于机制细胞蛋白属是一种非结构性细胞外基质 蛋白,这种蛋白调节细胞机制交互反应和和损伤组织或肿瘤内的 细胞功能。心脏应激或损伤期间该物质急剧升高表明他们在心脏 重塑中发挥重要作用。它可以作为急性冠脉综合症的标志物。 抗原 A50163H • Native antigen sourced from human platelets • > 95% pure (SDS-PAGE), lyophilized

组织纤溶酶原激活物(tPA)

H86177M H86180M H86180M H86177M H86177M H86178M H86178M H86177M 多抗 CATALOG

它是一种催化纤溶酶原向纤溶酶转化的丝氨酸蛋白酶,是斑块崩 解的主要作用酶。它的抗原水平升高是冠脉风险增加的标志物。 多抗 CATALOG SOURCE FORMAT APPLICATION K63250R Rabbit Purified EIA,IHC,WB

SOURCE FORMAT APPLICATION

H01379R Purified EIA, IEP H14115M Mouse Purified EIA, WB 抗原 R01619 • Recombinant (E. coli) • 122 a.a. long with N-terminal His tag • Suitable for use in ELISA 基质细胞衍生因子1α (SDF-1 α ) Rabbit 该物质是一种2种形式的细胞趋化因子,SDF-1α和SDF-1β轮流拼 接相同基因。研究表明SDF- α 水平在心脏疾病中水平升高。它已 经被作为房颤的预后标志物。

肌钙蛋白复合物

肌钙蛋白是一种三种常规蛋白(肌钙蛋白C、肌钙蛋白I和肌钙蛋 白T)形成的复合物也就是构成骨骼肌和心肌完整的肌肉收缩,但 非平滑肌。肌钙蛋白I和肌钙蛋白T是心肌不稳定心绞痛和心梗的 灵敏儿特异的标志物。肌钙蛋白C与心脏和骨骼肌有关但不能用 于心肌损伤的诊断。 抗原 A86608H • Native antigen from human heart tissue • >95% pure (SDS-PAGE) A86111H • Native antigen from human heart tissue • Complex of Troponin I-T-C in a molar . ratio 1:1:1

Antigen A42028H

• Recombinant (E. coli) • >98% pure (RP-HPLC and SDS-PAGE), lyophilized

21 | Cardiac & Metabolic Markers for Assay Development 用于开发心脏和代谢标志物体外诊断试剂的原料 21

抗体配对 • Suitable for use in ELISA • MAbs produced in vivo (unless otherwise noted) CAPTURE DETECTION H86465M H86458M

肌钙蛋白C-心脏 (cTnC) .该物质是肌钙蛋白复合物的一部分,负责与钙结合活化肌肉收 缩。在心肌中,该物质与心脏肌钙蛋白I结合延缓骨骼肌钙蛋白I 和慢抽搐骨骼肌的肌钙蛋白T。 抗原 A86857H • Native antigen from human heart tissue • > 98% pure (SDS-PAGE), lyophilized 肌钙蛋白I-心脏 (cTnI) 作为肌钙蛋白复合物的一部分,该物质在细肌丝中与肌动蛋白结 合,保持肌动-原肌球蛋白复合物的位置病在心肌组织内以单一同 种型出现。该物质具有一些磷酸化位点和磷酸作用变化模式对疾 病发生反应。磷酸化cTnI改变了蛋白质构造,修改了它与其他肌 钙蛋白的作用,改变了它对钙的肌丝反应。心脏肌钙蛋白I和T的 试验已经广泛作为心梗的诊断工具。 单抗 • Suitable for use in ELISA and WB • Reacts equally with free cardiac Troponin I (cTnI) and Complexed cTnI (unless otherwise noted) • Not affected by phosphorylation • Produced in vivo EPITOPE BINDING H01250M a.a. 1-15 * Also works in IHC H86008M a.a. 18-28 * Also works in IHC H01247M a.a. 148-158 * Also works in IHC, reacts mostly with free cTnI (not complexed) H86267M a.a. 169-178 H86550M a.a. 186-192 H86004M a.a. 190-196 * Also works in IHC H86307M a.a. 25-40 H01340M a.a. 41-49 H86207B a.a. 41-49 * Biotin conjugated H01246M a.a. 65-74 * Also works in IHC, reacts with free cTnI only (not complexed) H86286M a.a. 86-90 * Also works in IHC H86241M a.a. 86-90 H86596M a.a. 169-178 * Also works in IHC • Suitable for use as a standard, immunogen for antisera production, tracer for iodination

* Also works in WB and IP, no cross-reactivity with skeletal . muscle troponin I * K31341G is a polyclonal (goat) cTnI, also works in IHC * K31342G is a polyclonal (goat) cTnI, also works in IHC

K31015M K31341G K31015M K31342G H01326M H01325M H86285M H01347M H01395M H01343M H01395M H86465M H01395M H86280M H86625M H01395M H01395M H01396M H01340M H01396M 多抗 CATALOG

* Also works in LF * Also works in WB

* Also works in WB * Also works in WB * Also works in WB

SOURCE FORMAT APPLICATION

K01350G Goat K31342G Goat

Aff.Pur. Aff.Pur.

EIA

EIA,IHC

* K31342G reacts with region a.a. 69-86 抗原 R01620

• Recombinant (E. coli) • 95% pure (SDS-PAGE Coomassie staining) • Suitable for use in ELISA • Recombinant (P. pastoris) Complex of cTnI (fragment) and cTnC (full length) • > 85% pure (determined by SDS-PAGE) • Suitable for use in ELISA and WB • Native antigen from human heart • >98% pure (SDS-PAGE) • Suitable for use in ELISA, as antigen for antisera production, and as a tracer for iodination • Native antigen from human heart • >98% pure (SDS-PAGE) • Calibrator Set using native antigen from . human heart • Calibrators correspond to 0, 0.5, 1, 3, 10, 50, and 100 ng/mL Cardiac Troponin I

A01429H

A86853H

A38150H

A86860H

22

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