Cancer & Tumor Markers Catalog

Product list | Continued

Monoclonals • Recognizes Cadherin-E expressed on non-neuronal epithelial cells

Beta 2 Microglobulin (B2M) B2M is a protein involved with MHC class I molecules which is found on the surface of almost all nucleated cells. Elevated levels of B2M are noted in lymphoproliferative disorders, neoplasms (malignant and benign), inflammatory disease, and autoimmune diseases such as systemic lupus erythematosus and Sjögren’s disease. For cancer, it is not diagnostic for a specific type, but it has been associated with the amount of cancer present (tumor burden) and can be used as a prognostic tumor marker for some blood cell cancers. Monoclonals • Recognizes the HLA-B2M complex, free or associated with the membrane • Suitable for use in FC, IHC and IFA • Lyophilized H42114M • Reacts with soluble forms of B2M and B2M associated with cell-surface MHC Class I molecules and other membrane antigens • Suitable for use in ELISA, WB, FC, IP, and RIA MCP17-301 Polyclonals CATALOG SOURCE FORMAT APPLICATION K01372G Goat Aff.Pur. N/A Antigens A01447H • Native antigen from human urine

• Suitable for use in IHC and IP • Produced in vivo , lyophilized P91176M

Calcitonin Calcitonin is polypeptide hormone that is produced by the C-cells of the thyroid gland and it acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH). Calcitonin assay is used to identify patients with nodular thyroid diseases and to diagnose medullary thyroid cancer. Antibody Pairs

• Suitable for use in CLIA, ELISA and RIA • Recognizes Native Human Calcitonin CAPTURE DETECTION E01357M E01356M

Calprotectin L1 Calprotectin L1 is a neutrophil-derived protein that can be quantified in the feces and has become an established marker of whole gut inflammation. Fecal calprotectin levels are associated with lifestyle risk factors for colorectal cancer. Antibody Pairs

• Suitable for use in ELISA with stool samples • MAbs produced in cell culture, lyophilized CAPTURE DETECTION K01373M K01376M

• Suitable for use in ELISA • 98% Purity (SDS-PAGE)

A01410H

• Native antigen from human urine • > 98% Purity (SDS-PAGE), lyophilized • Native antigen from human urine • 98% Purity (SDS-PAGE) • Recombinant (E.coli) • 95% Pure (HPLC), lyophilized

• MAb to Calprotectin • Produced in cell culture • Suitable for ELISA and lateral flow CAPTURE DETECTION 9591 9591 Monoclonals • Suitable for use in ELISA • Produced in cell culture, lyophilized

A01412H

A01468H

Cadherin-E Cadherin-E is a calcium dependent cell adhesion molecule expressed predominately in epithelial tissues. It plays an important role in the growth and development of cells via the mechanisms of tissue architecture and the maintenance of tissue integrity. It is an important determinant of tumor progression, serving as a suppressor of invasion and metastasis (loss of Cadherin-E function promotes tumor progression).

K01374M K01375M

6 | Cancer & Tumor Markers for Assay Development Cancer & Tumor Markers- Reagents for Assay Development 6

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