Cancer & Tumor Markers Catalog

Product list | Continued

Trypsin Trypsin is a serine protease family member found in the digestive system where it hydrolyses proteins. It is expressed by many tumors and plays a significant role in tumor invasion, especially in stomach cancer cells. Elevated expression of trypsin in colorectal cancer also correlates with unfavorable clinicopathological characteristics and shortened survival. Antigens A50188H • Native antigen from human pancreas • > 95% pure (SDS-PAGE), lyophilized Tumor Necrosis Factor alpha (TNF-alpha) TNF-alpha is a cytokine produced by activated macrophages and is involved in the regulation of immune cells. Dysregulation of TNF production has been implicated in a variety of diseases including cancer, Alzheimer’s, Psoriasis, and inflammatory bowel disease. In breast cancer, high TNF-alpha serum concentrations correlate with late-stage breast tumor phenotypes suggesting a role of TNF-alpha as a breast cancer marker. Antibody Pairs • Suitable for use in ELISA, IHC and neutralization • Produced in vivo CAPTURE DETECTION H86410M H86650M Urokinase (uPA) uPA is a serine protease used clinically as a thrombolytic agent in the treatment of severe or massive deep venous thrombosis, pulmonary embolism, and myocardial infarction. Substantial evidence implicates uPA, urokinase plasminogen activator receptor (uPAR) and plasminogen activator inhibitor-1 (PAI-1) in the neo-vascularization, invasion and metastasis of many solid tumors. Clinical studies have demonstrated an association between high levels of expression of this system in tumors and poor patient prognosis and outcome. Polyclonals CATALOG SOURCE FORMAT APPLICATION K63819R Rabbit Purified ELISA,IHC,WB

Vitronectin Vitronectin is a glycoprotein that regulates proteolysis initiated by plasminogen and is involved in hemostasis. Studies have shown that serum levels of Vitronectin are correlated with tumor size, and clinical stage suggesting that it could serve as a promising serum marker for the early diagnosis of breast cancer. Monoclonals • Suitable for use in ELISA and IB • Produced in cell culture N77810M Polyclonals CATALOG SOURCE FORMAT APPLICATION K63964R Rabbit Purified ELISA,WB Antigens A63731H • Native antigen from human plasma • > 95% pure (SDS-PAGE)

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24 | Cancer & Tumor Markers for Assay Development

Cancer & Tumor Markers- Reagents for Assay Development

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