Cancer & Tumor Markers Catalog

Antibody Pairs • Suitable for use in ELISA • Produced in vivo CAPTURE DETECTION E01311M E01309M E01310M E01309M Antigens A01309H

Superoxide Dismutase (SOD) SODs are a group of metalloenzymes (containing Fe, Mn, or Cu and Zn) that are an important antioxidant defense in all living cells. Many human tumors have shown significant changes in the activity and expression of SODs. The ratio of MnSOD to CuZnSOD activity has been suggested as a potential biomarker for gastric adenocarcinoma. Monoclonals • Specific for Cu/Zn SOD • Suitable for use in ELISA and WB • Produced in vivo H86141M

• Recombinant (Baculovirus), a.a. 19-846 • Suitable for use in ELISA and WB • 95% pure (SDS-PAGE), lyophilized

Thyroglobulin (Tg) Thyroglobulin is a dimeric protein produced by the follicular cells of the thyroid and is the precursor of thyroid hormones thyroxine (T4) and triiodothyronine (T3). It is an FDA approved tumor marker to evaluate the effectiveness of treatment for differentiated thyroid cancer and to monitor for recurrence. Antibody Pairs • Suitable for use in ELISA • Produced in vivo CAPTURE DETECTION E01326M E01325M Antigens A86852H • Native antigen from human thyroid • Suitable for use as a standard, for antibody TissueTransglutaminase (tTG) tTG is a calcium-dependent enzyme which catalyzes the crosslinking of proteins and plays a role in apoptosis, cell adhesion, metastasis, and extracellular matrix assembly. tTG is particularly notable for being the autoantigen in coeliac disease and has also shown to play a role in regulating tumor growth and metastasis in breast cancer. Antigens A01363H • Recombinant (HEK-293-EBNA cells) • Suitable for use in ELISA • 95% pure (SDS-PAGE), lyophilized R01650 • Recombinant ( Sf-21 Insect Cells) production or as a tracer for iodination • > 90% pure (SDS-PAGE), lyophilized

Thymus and Activation Regulated Chemokine (TARC)

TARC is a small CC chemokine that is constitutively expressed in the thymus. It is known to play an important role in Th2-mediated immune-inflammatory processes. Aberrant TARC expression is observed in many diseases including cancer, autoimmune disorders, and atherosclerosis. Serum TARC is a promising serum biomarker for gastric cancer and induces metastasis of breast cancer cells. Antigens A28330H • Recombinant (E. coli) • >97% pure (SDS-PAGE and HPLC analysis), lyophilized Thyroid Peroxidase (TPO) TPO is a membrane thyroid enzyme essential for thyroid hormone synthesis and it is present in large quantities in the cytoplasm of normal thyrocytes. In malignant tumors, TPO synthesis is inhibited to varying degrees and maturation is deregulated resulting in overexpression of short splice variants. It has diagnostic utility as a tumor marker in thyroid cancer. Monoclonals • Can be used for affinity purification of human TPO • Produced in vivo E86415M

• Suitable for use in ELISA • 90% Pure (SDS-PAGE)