Product list | Continued
Cancer Antigen 19-9 (CA19-9)
Cancer Antigen CA72-4 (TAG-72)
Also called sialylated Lewis (a) antigen, CA19-9 is a tumor marker used primarily in the management of pancreatic cancer. CA19-9 is also elevated in many types of gastrointestinal cancer, such as colorectal cancer, esophageal cancer and hepatocellular carcinoma. Apart from cancer, elevated levels may also occur in pancreatitis, cirrhosis, and diseases of the bile ducts. Monoclonals • Suitable for IHC • Produced in in vivo M01237M Antibody Pairs • Suitable for use in ELISA • MAbs produced in vivo (unless otherwise noted) CAPTURE DETECTION
CA72-4 is a mucinous glycoprotein used as a tumor marker for gastric carcinoma and ovarian cancer (clinical studies demonstrated diagnostic specificity of more than 95%). Elevated CA72-4 levels in serum and plasma have also been reported in other cancers including carcinomas of the pancreas, stomach, gallbladder, colon, cervix and endometrium. There is a good correlation between serologic CA72-4 levels and tumor stage and size. It has been used as an independent marker for the therapeutic monitoring and follow-up care of ovarian cancer patients, in particular in CA125 negative patients. Antibody Pairs
• Suitable for use in ELISA • MAbs produced in vivo CAPTURE DETECTION M01341M M01340M M01342M M01340M
M66106M M66108M M66107M M66106M M66107M M66108M M66108M M66106M Antigens A32502H
* Pair does not cross-react CA72-4, PSA, CA125, CA242, and CEA
Cancer Antigen 242 (CA242)
CA242 is related to the sialylated Lewis (a) blood group antigen (Ag-CA19-9) but it is chemically and immunologically distinct. It is used as a tumor marker for the early diagnosis of pancreatic cancer. It has been demonstrated that the CA242 and CA19-9 epitopes are co-expressed on the same mucins, however the detailed structure of the CA242 epitope has not been established. CA242 is suggested to be more specific than CA19-9 in the diagnosis of pancreatic cancer and overall there are differences in the relative expression of CA19-9 and CA242 between benign and malignant diseases and between carcinomas of various organs. Antigens A01267H • Cell culture derived protein • Suitable for use as a calibrator Please note that cell culture derived antigens offer several advantages over the native fluid versions, including greater availability of the product.
• Cell culture derived protein from human adenocarcinoma cell line • Suitable for use in CLIA • Native antigen from metastatic liver carcinoma • Suitable for use as a calibrator and an immunogen for antibody development • Cell culture derived protein • Concentrated (~76,000 U/mL), lot dependent
A86199H
A01458H
Please note that cell culture derived antigens offer several advantages over the native fluid versions, including greater availability of the product.
Cancer Antigen 50 (CA50)
CA50 cancer antigen is a glycolipid and elevated levels of CA50 are found in liver cirrhosis and diseases of the pancreas. CA50 is most prevalent in gastrointestinal cancers, but can also be associated with cancer outside the digestive tract. Antigens A01264H • Cell culture derived protein Please note that cell culture derived antigens offer several advantages over the native fluid versions, including greater availability of the product.
8 | Cancer & Tumor Markers for Assay Development Cancer & Tumor Markers- Reagents for Assay Development 8
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