Cancer & Tumor Markers Catalog

Carcinoembryonic Antigen (CEA) CEA is a type of glycoprotein molecule that is produced by cells of the gastrointestinal tract during embryonic development and CEA is generally present in low levels in the blood. Elevated levels of CEA are detectable in certain types of cancer and to-date CEA is the most widely used tumor marker for assessing prognosis, detecting recurrence and monitoring treatment in people with colorectal cancer. High levels of CEA are also detectable in cancers of the pancreas, stomach, breast, lung, medullary carcinoma of the thyroid, and ovarian cancer. Monoclonals • Suitable for use in enzyme conjugation, radio-labeling or solid phase immobilization • Produced in vivo H45655M • Suitable for use in FC • Specific for epitope group V M01329M Antibody Pairs

Catalase Catalase is an important enzyme that protects cells from oxidative damage by reactive oxygen species. Catalase is frequently down-regulated in tumors although the underlying mechanism remains unclear. It has been recommended for use as a biomarker for the diagnosis, prognosis, and treatment of breast cancer.

Antigen A50136H

• Native antigen from human erythrocyte • 95% pure (SDS-PAGE) • > 50,000 units/mg protein (lot dependent)

CD1d CD1d encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. Studies have shown that breast cancer cells, through downregulation of CD1d and subsequent evasion of NKT-mediated antitumor immunity, gain increased potential for metastatic tumor progression. Monoclonals • Suitable for use in IHC and IP • Produced in cell culture P01242M CD3 CD3 consists of a protein complex with four chains and it is required for T-cell activation. CD3 expression can be detected at all stages of T-cell development. Studies have shown that patients with an unresponsive CD3 receptor have a significantly higher incidence of recurrent head and neck squamous cell carcinoma. CD3 is also under investigation as a target for immunosuppressant therapies for type 1 diabetes and other autoimmune diseases. Monoclonals • Produced in vivo MAL66-801

• Suitable for use in ELISA • MAbs produced in vivo CAPTURE DETECTION MAM02-008 MAM02-009 MAM02-009 MAM02-007 MAM02-009 MAM02-008 MAM02-009 MAM02-881 M01250M M01246M

* Also works in IHC

Polyclonals CATALOG SOURCE FORMAT

APPLICATION

K10290G Goat

Neat

ELISA

Antigens A01442H

• Native antigen from human fluids • Suitable for use in ELISA • 98% (SDS PAGE) • Native antigen from human fluids • Suitable for use in ELISA • Purified antigen from cell culture • > 50% pure (SDS-PAGE) • Purified antigen from human colon adenocarcinoma cell line • 95% pure (SDS-PAGE)

A86808H

A32030H

A38151H

Please note that cell culture derived antigens offer several advantages over the native fluid versions, including greater availability of the product.