Product list | Continued
CD8 CD8 is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor. CD8-positive T-cells represent a major arm of the cell-mediated anti-tumor response and a promising target for developing T-cell-based immunotherapies against lung cancer. The chronic presence of lung tumors induces dysfunctions in CD8-positive T-cells and sensitizes them to activation-induced cell death, which may be associated with poor clinical responses. Monoclonals • Produced in vivo MAL08-804
CD24 CD24, a heat stable antigen, is a surface marker expressed in many tumor types. It has been identified as a marker of cancer stem cells (CSCs) and several studies suggest that CD24-positive tumors are related to a poor prognosis and for several cancer types. Monoclonals • Recognizes B-cells from pre-B to mature-B stage
• Suitable for use in FC and IHC • Produced in vivo , lyophilized P42118M
CD28 CD28 is one of the proteins expressed on T-cells that provides co-stimulatory signals required for T-cell activation and survival. It is also the receptor for CD80 and CD86 proteins. Studies have shown that it is a marker associated with tumoral expansion in multiple myeloma. Monoclonals • Induces T-cell proliferation in co-stimulation with CD2 monoclonal antibodies • Suitable for use in FC • Produced in vivo P42235M CD30 CD30 is a cell membrane protein of the tumor necrosis factor receptor family and a tumor marker. CD30 is associated with anaplastic large cell lymphoma. It is expressed in embryonal carcinoma and on classical Hodgkin Lymphoma Reed-Sternberg cells. In 2011, the FDA approved an agonistic anti-CD30 drug conjugate, Brentuximab vedotin, for the treatment for CD30-positive lymphomas Monoclonals • Suitable for use in FC, IHC and IFA • Produced in vivo , lyophilized P42705M
CD13 (Aminopeptidase N)
CD13 is a Zn 2+ dependent membrane-bound ectopeptidase that preferentially degrades proteins and peptides with a N-terminal neutral amino acid. It has been associated with the growth of different human cancers and is suggested to be a suitable target for anti-cancerous therapy. Monoclonals • Suitable for use in FC and IHC • Produced in cell culture, biotin conjugated P01150B
CD15
CD15 is a complex cluster of cell surface glycoproteins and glycolipids having a common terminal pentasaccaharide known as the Lewisx (Lex) antigen. In haematopathology, CD15 is important for the diagnosis of classical Hodgkin’s disease and the characterization of acute leukemia. CD15 may be used for histopathological grading of gliomas and differentiating between malignant gliomas and non-neoplastic glial cells. Hepatocellular, gastric, and colonic carcinoma and thyroid medullary carcinoma also appear to have worse prognosis if positive for CD15. Monoclonals • Suitable for use in FC, IHC and IFA • Produced in cell culture P01158B
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Cancer & Tumor Markers- Reagents for Assay Development
10 | Cancer & Tumor Markers for Assay Development
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