Cancer & Tumor Markers Catalog

CD37 CD37 antigen is a transmembrane protein of the tetraspanin superfamily that is highly expressed on B-cells during the pre-B to peripheral mature B-cells. In normal tissues, CD37 expression is restricted to lymphoid tissues. However, CD37 is highly expressed on malignant B-cells in non-Hodgkin lymphoma and chronic lymphocytic leukemia which suggests that CD37 could be a promising therapeutic target for B-cell malignancies. Monoclonals • Suitable for use in ELISA, IHC and IP • Produced in vivo K8A069M CD42 CD42 is a cell-surface glycoprotein involved in cell–cell interactions, cell adhesion and migration. It participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Monoclonals

CD57 CD57 is a glycoprotein with cell adhesion functions normally expressed on NK-cells. It serves as a marker of NK cells and neuroendocrine tumors and helps distinguish high grade prostatic adenocarcinoma (CD57-positive) from high grade urothelial carcinoma (CD57-negative). Monoclonals • Suitable for use in WB, IHC and FC • Produced in cell culture P01287M CD59 CD59 is a glycoprotein expressed on all human peripheral blood leukocytes, erythrocytes, and several human cell lines. It is a potent inhibitor of the complement membrane attack complex (MAC) action. Its overexpression has been observed in many types of solid cancers, such as pancreatic cancer and lung cancer. Monoclonals • Reacts with a well-defined epitope (W40, R-53) on CD59 • Suitable for use in FC and IP • Produced cell culture MAL59-043 CD66b CD66b, also known as carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8), is expressed mainly on granulocytes such as a GPI anchored molecule and its main functions are cell adhesion, cell migration, and pathogen binding. Under normal conditions, neutrophils have minimal expression of CD66b, however, in chronic myeloid leukemia its expression is upregulated. Monoclonals

• Specific for CD42b • Suitable for use in FC • Produced in vivo , lyophilized N42409M

CD49d CD49d is an integrin alpha subunit composed of a β 4 (CD49d) and a β 1 (CD29) chain and serves as a receptor for fibronectin and VCAM-1. It is normally expressed on monocytes, T-cells, and eosinophils and mainly functions as a cell adhesion and signaling molecule. In cancer, it is an independent prognostic marker for disease progression in patients with chronic lymphocytic leukemia. Monoclonals

• Suitable for use in FC and IFA • Produced in vivo , FITC labelled P42531F

• Suitable for use in FC and IFA • Produced in vivo , lyophilized P42764M