Product list | Continued
CD71 CD71, the transferrin receptor, is involved in the cellular uptake of iron and is expressed on cells with high proliferation. Data suggests that it might be implicated in promoting the growth of endocrine resistance in breast cancer and may serve as a prognostic marker of poor outcome and resistance to tamoxifen. Monoclonals • Recognizes soluble and bound transferrin receptor • Suitable for use in ELISA and WB • Produced cell culture H01372M • Suitable for use in ELISA and WB • Produced in vivo H86602M CD90 CD90 is a cell surface glycoprotein involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. It is widely used as a marker for hematopoietic stem cells and has been identified as a valuable marker to differentiate epithelioid mesothelioma from lung carcinoma. It may also function as a tumor suppressor in nasopharyngeal carcinoma. Monoclonals • Suitable for use in WB, IFA, FC, and IP • Produced in cell culture P01283M CD105 (Endoglin) CD105 is an accessory protein of the transforming growth factor-beta receptor system and is expressed on vascular endothelial cells. Studies have identified CD105 expression in several solid tumor types, with the level of expression correlating to various clinicopathologic factors including decreased survival and presence of metastases. It is an independent predictive marker for death risk and unflavorable prognosis in patients with renal cell carcinoma. Monoclonals • Suitable for use in WB, IP and FC • Produced in vivo MAL105-226
CD147 CD147, an extracellular matrix metalloproteinase inducer, is correlated with tumor aggressiveness in various human malignanciesis including ovarian and gastric cancers. Its expression is highly associated with cancer invasion and metastasis and it has the potential to serve as a prognostic biomarker (e.g. poor outcome). Monoclonals • Recognizes an epitope in the N-terminal Ig domain (D1) • Suitable for use in FC • Produced in vivo P87535M * Also works in WB and IP
CD177
CD177 is an important membrane glycoprotein on neutrophils and serves as a marker for myeloproliferative diseases. Loss of CD177 expression is linked to higher metastasis incidence and shorter survival in breast cancer patients. Monoclonals • Suitable for use in WB, FC and IP • Produced in vivo MAL177-166
CD195 (CCR5)
CD195 is a protein on the surface of white blood cells that is involved in the immune system and it acts as a receptor for chemokines, specifically CCL3 (MIP1 α ), CCL4 (MIP1 β ) and CCL5 (RANTES). It is also used by HIV (along with CXCR4) to enter target cells. CD195 has been implicated to play a role in the metastasis of breast cancer and colorectal cancer. Monoclonals
• Suitable for use in FC • Produced cell culture P01240M
12
12 | Cancer & Tumor Markers for Assay Development
Cancer & Tumor Markers- Reagents for Assay Development
Powered by FlippingBook