Cancer & Tumor Markers Catalog

Centromere Protein B (CENPB) CENPB is a highly conserved DNA protein that facilitates centromere formation. It is used as a serologic marker for autoimmune diseases, specifically sclerosis and other rheumatic conditions. It is also a potential biomarker of small-cell lung cancer and a prognostic marker for breast cancer (indicating prolonged survival). Antigens A01375H • Recombinant ( Sf9 Insect Cells) • Suitable for use in ELISA and WB • > 95% pure (SDS-PAGE)

Cyfra 21-1, Cytokeratin 19 Fragment Cyfra 21-1 is a sensitive and specific tumor marker of lung cancer, especially of the squamous cell subtype. An assay for Cyfra 21-1 was first approved by the FDA in 2011 to monitor disease progression and treatment of lung cancer patients. It is also reported to be a potential biomarker for ovarian cancer. Monoclonals • Suitable for use in ELISA • Produced in vivo

M01300M Antigens A32340H

R01646

• Recombinant ( Sf9 Insect Cells) • Suitable for use in ELISA and WB • 90% pure (SDS-PAGE)

• Native antigen from MCF-7 Cell Supernatant • Calibrator Grade with low cross-reactivity • Suitable for use in CLIA

c-Myc c-Myc a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. A mutated version causing consituative expression of c-Myc is found in many cancers, including Burkitt lymphoma the cervical, ovarian, colon, breast, lung and stomach cancers. Monoclonals • Produced in vivo MAB07-510 * Suitable for use in WB and IHC Collagen Type VI Collagen Type VI is a widely distributed extracellular matrix macromolecule that plays a crucial role in tissue development and is highly expressed in cancers. Studies show that it promotes chemotherapy resistance, and specifically in breast cancer it regulates cancer progression and metastasis. Antigens A33129H • Native antigen from human placental villi • Suitable for use as a standard, or for antibody production • > 90% pure (SDS-PAGE)

Defensin-beta Human defensins are small cationic peptides produced by neutrophils and epithelial cells and they form two genetically distinct alpha and beta subfamilies. Defensins are involved in various aspects of the innate and acquired immune responses and recently, single nucleotide polymorphisms of beta-defensins have been correlated with increased susceptibility to cancer. Specifically, in oral cancer beta-defensins are down-regulated indicating that it may play a role in tumor suppression. Monoclonals • Suitable for use in ELISA • Produced in cell culture, lyophilized EPITOPE BINDING P24141M a.a. 1-36, Defensin-beta 1 * Also works in WB P24011M a.a. 4-41, Defensin-beta 2 Antigens A24100H • Synthetic peptide representing a.a. 4-41 (Defensin-beta 2) • > 95% pure (HPLC), lyophilized A24601H • Synthetic peptide representing a.a. 3-39 (Defensin-beta 4) • > 95% pure (HPLC), lyophilized