Cancer & Tumor Markers Catalog

erbB-2, HER2/neu Receptor tyrosine-protein kinase erbB-2 also frequently called HER2 (human epidermal growth factor receptor 2) is a member of the human epidermal growth factor receptor family. Overexpression of HER2 plays an important role in the development and progression of certain aggressive types of breast cancer. Approximately 15% of all newly diagnosed breast cancers are HER2-positive and the purpose of HER2 testing is to identify patients who could benefit from effective HER2-targeted therapies, such as trastuzumab (Herceptin), lapatinib (Tykerb), pertuzumab (Perjeta), and T-DM1 (Kadcylapatients). Monoclonals

Factor H (Beta 1H)

Factor H is a member of the regulators of the complement activation family and is a complement control protein. There are a number of clinical implications arising from aberrant factor H activity including stroke, schizophrenia and cancer. Specifically, it has been identified as a tumor marker for bladder cancer. Polyclonals CATALOG SOURCE FORMAT APPLICATION K90030C Sheep Purified DD,IE,IEP

Factor VIII (FVIII)

• Reacts with peptide ILDV4 • Suitable for use in ELISA • Produced in vivo M01296M

FVIII is an essential blood-clotting protein, also known as anti-hemophilic factor. Inhibitors to FVIII develop in malignancies which can lead to an acquired hemophilic state and an increased risk for deep vein thrombosis and pulmonary embolism. Monoclonals • Antibody binds human factor VIII A2 domain in immunoblotting techniques • Suitable for use in ELISA and WB N01277M

* Reacts with peptide ILDV4 (dephosphorylated) * Reacts with peptide ILDV4 (phosphorylated) * Reacts with peptide ILDV2 (dephosphorylated) * Reacts with peptide ILDV2 (phosphorylated)

M01297M M01298M M01299M Antigens R01605

• Recombinant (HEK293 cells) • Suitable for use in ELISA • 95% Pure (SDS-PAGE), lyophilized, contains a His-tag

Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH)

Epithelial Cell Adhesion Molecule (EpCAM) EpCAM is a glycoprotein involved in cell-cell adhesion, signaling, cell migration, proliferation, and differentiation. Its expression is restricted to normal epithelial cells in healthy individuals but in cancer, its expression distribution varies depending on the type of carcinoma. It is considered a tumor-associated antigen and may act as a potential prognostic marker for various cancers. Monoclonals • Suitable for use in ELISA and WB • Produced in vivo M01310M * Recognizes a.a. 116-242

GAPDH catalyzes the conversion of glyceraldehyde-3-phosphate to D-glycerate 1,3-bisphosphate which is the 6th step in the process of glycolysis. It is overexpressed in multiple human cancers, such as cutaneous melanoma, and its expression is positively correlated with tumor progression. It has also been implicated in several neurodegenerative diseases and disorders. Monoclonals

• Suitable for use in ELISA and WB • Produced in vivo , HRP conjugated

H86045P H86504P

* Reacts with monomeric and dimeric forms (not tetrameric form), also works in IFA and ICC

Antibody Pairs • Suitable for use in ELISA • Produced in vivo CAPTURE DETECTION H86504M H86045M

* Reacts with monomeric and dimeric forms (not tetrameric form), also works in WB

H86504M H86903M