Product list | Continued
Heat Shock Proteins Heat shock proteins are involved in protein folding, stability, transport and transcriptional regulation. They are also known to participate in many pathological processes, such as asthma, intimal hyperplasia, and insulin resistance. In addition they have a cytoprotective role and are essential for cancer cell survival and are often upregulated in cancer. Specifically, HSP20 may have value as a prognostic tumor marker for colorectal cancer and HSP27 as a prognostic marker of prostate cancer. Monoclonals • Suitable for use in ELISA, WB and IFA • Produced in vivo H86201M * Recognizes human recombinant HSP20 and HSP20 from human cardiac tissue Hemoglobin Hemoglobin is the iron-containing metalloprotein in red blood cells that transports oxygen. In diseases related to gastrointestinal bleeding such as colorectal cancer, hemoglobin is leaked into gastrointestinal tract and then discharged with the feces. Fecal occult blood tests (FOBT) are the specific name for assays that detect blood in the stool. Many commercial assays are ELISA or lateral flow based antigen detection assays that use antibodies specific to hemoglobin. Antibody Pairs • Suitable for use in ELISA CAPTURE DETECTION H01417M H01416M *Hemoglobin • MAb to Hemoglobin (FOB) • Recognizes Human Hemoglobin • Suitable for use in Lateral Flow and Turbidimetry (Latex) CAPTURE DETECTION H01409M H01410M Antigens A01703N • Suitable for use in LF • Purified, Liquid
Human Epididymis Protein 4 (HE4) HE4 belongs to the family of whey acidic four-disulfide core proteins and currently, the biologic function of HE4 is unknown. Expression of HE4 is found in the glandular epithelium of the reproductive tract, distal renal tubules, and respiratory epithelium. In cancer, the highest serum levels of HE4 are found in epithelial cancer, serous ovarian cancer and endometrioid cancer. The main established application of HE4 is in post- therapy monitoring of ovarian cancer patients who had elevated pretreatment levels with little or no expression of CA125. Antibody Pairs • Suitable for use in ELISA • Produced in vivo CAPTURE DETECTION
M01323M M01320M M01323M M01321M M01323M M01322M Antigens A01469H
• Native antigen from human epididymis cell line • Suitable for use in CLIA
A01466H
• Native antigen from human fluids • Suitable for use in CLIA • 90% Pure (SDS-PAGE)
Insulin Like Growth Factor I (IGF-I or Somatomedin C)
IGF-I is a peptide hormone involved in regulating human growth and development and is similar in molecular structure to insulin. It is produced primarily by the liver as an endocrine hormone and is a strong mitogen for a wide variety of cancer cell lines, including sarcoma, leukemia, and cancers of the prostate, breast, lung, colon, stomach, esophagus, liver, pancreas, kidney, thyroid, brain, ovary, and uterus (both cervical and endometrial). Monoclonals • Suitable for use in ELISA and RIA • Produced in cell culture E54061M
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16 | Cancer & Tumor Markers for Assay Development
Cancer & Tumor Markers- Reagents for Assay Development
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