Cancer & Tumor Markers Catalog

Insulin Like Growth Factor Binding Protein 3 (IGFBP-3) IGFBP-3 is a transporter protein produced in the liver that is thought to regulate growth through its main binding protein Insulin-like growth factor-1 (IGF-1). High circulating concentrations of IGF-I are associated with an increased risk of cancer (especially breast cancer), whereas IGFBP-3 concentrations are associated with a decreased cancer risk. Antibody Pairs • Suitable for use in CLIA, ELISA and RIA • Recognizes native and recombinant Human IGFBP-3 CAPTURE DETECTION K01411M K01410M Integrin alpha M (CD11b/MAC-1) The Integrin alpha M subunit, also known as MAC-1 alpha subunit or CD11b, combines with the integrin beta 2 subunit (CD18) to form the non-covalent heterodimer integrin alpha M/beta 2, also known as the MAC-1 receptor. Integrin alpha M has been suggested to be an independent prognostic factor of gastric cancer patients, as well as lymph node metastasis and tumor size. Monoclonals • Produced in vivo , FITC labelled P42530F Interferon gamma (IFN-gamma) IFN-gamma is a cytokine that plays physiologically important roles in promoting innate and adaptive immune responses. In cancer, it has been shown to prevent the development of primary tumors, regulate tumor growth and to promote the host response to tumor. Monoclonals • Suitable for use in ELISA • Produced in vivo P18442M * Neutralizing antibody, lyophilized P86424M * Also works in WB Antibody Pairs • Suitable for use in ELISA and WB • Produced in vivo CAPTURE DETECTION P86842M P01309M

Interleukin 1 alpha (IL-1a) and Interleukin 1 Receptor (IL-1R)

IL-1a is a pleiotropic cytokine that is localized in the cytosol or cell membrane and is believed to regulate the intracellular environment. Its receptor is IL-1R and it is responsible for mediating its effects. It is known to be upregulated in many tumor types and has been implicated as a factor in tumor progression via the expression of metastatic and angiogenic genes and growth factors. Antigens A42201H • Recombinant IL-1a (E. coli) • > 97% pure (HPLC and SDS-PAGE), lyophilized Lactate Dehydrogenase (LDH) LDH is an enzyme composed of four subunits that catalyzes the conversion of lactate to pyruvic acid. It is released during tissue damage and is involved in tumor initiation and metabolism. Studies have shown differential expression between the LDH isoenzymes and overall, LDH expression can act as a general marker in the prognosis of cancers. Specifically expression of LDH-5 in tumors and the stroma has been found to be a strong prognostic factor for diffuse or mixed-type gastric cancers. Antigens A38357H • Native LDH sources from human heart • Specific Activity: 260 Units/mg protein (lot dependent) • Purified by ammonium sulfate precipitation

A38155H

• Native LDH1 from human erythrocytes • Specific Activity: 125 Units/mg protein (lot dependent) • Ammonia sulfate suspension • Native LDH2 from human erythrocytes • Specific Activity: 300 Units/mg protein (lot dependent) • Ammonia sulfate suspension • Native LDH3 from human erythrocytes • Specific Activity: 240 Units/mg protein (lot dependent) • Ammonia sulfate suspension • Native LDH4 from human erythrocytes • Specific Activity: 220 Units/mg protein (lot dependent) • Ammonia sulfate suspension • Native LDH5 from human erythrocytes • Specific Activity: 460 Units/mg protein (lot dependent) • Ammonia sulfate suspension

A38252H

A38353H

A38454H

A38558H