Product list | Continued
Lysozyme
Leptin Leptin is a hormone made by adipose cells that helps to regulate energy balance by inhibiting hunger and regulating of fat stores. In the context of cancer, leptin expression can be induced under hypoxic conditions which often occurs in solid tumors. Leptin expression is upregulated in several types of cancer including breast, colorectal, prostate, ovarian, and lung cancer. Monoclonals • Suitable for use in IHC and ELISA • Produced in vivo H4A342M * Reacts with C-terminal, a.a. 92-145 Antigens A42327H • Recombinant (E. coli) • > 95% pure (RP-HPLC and SDS-PAGE), lyophilized Lamin Lamins are the major component of the nuclear lamina with several functions including structural support of the nucleus, facilitating chromatin organization, gene regulation and DNA repair. They are often aberrantly expressed or localized in tumors and they are suggested to be a marker of good or poor patient survival depending on tumor subtype. In prostate cancer, lamins are specifically involved in cell proliferation, migration and invasion. Polyclonals CATALOG SOURCE FORMAT APPLICATION T24210R Rabbit Purified IHC,WB T24210R is specific for Lamin 5 Antigens A24210H • Native Lamin 5 from human foreskin keratinocytes • Suitable for use in WB • > 95% pure (SDS-PAGE)
Lysozymes are enzymes that damage bacterial cell walls and they can be found in a number of secretions, such as tears, saliva, human milk, and mucus. In certain cancers (especially myelomonocytic leukemia) excessive production of lysozyme by cancer cells can lead to toxic levels of lysozyme in the blood leading to kidney failure and low blood potassium. Antigens A01399H • Recombinant (rice seed) • 90% pure (SDS-PAGE), lyophilized
Microtubule Associated Protein 2 (MAP-2)
MAP-2 is a protein involved in microtubule assembly, an essential step in neuritogenesis. Accumulating evidence shows that changes in the expression or post-translational modification of MAPs can contribute to the dysregulation of microtubule dynamics and consequently lead to the development of serious diseases, including cancer. MAP-2 has specifically been implicated to play a role in oral cancer. Monoclonals • Reacts with high molecular weight forms of MAP-2 (2a&2b) • Suitable for use in WB and IHC (unless noted otherwise) • Produced in cell culture Q01119M
Mast CellTryptase (MCT)
MCT is considered to be an important marker of mast cell activation as well as an important mediator of inflammation and angiogenesis. It plays a role in pancreatic cancer angiogenesis and tumor growth and in breast cancer invasion
and migration. Monoclonals • Recognizes alpha and beta isoforms of MCT • Suitable for use in ELISA, WB and IHC • Produced in cell culture H01317M
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18 | Cancer & Tumor Markers for Assay Development
Cancer & Tumor Markers- Reagents for Assay Development
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