ToRCH IgG/IgM Assay Development Guide

Commercial Assays & Recommended Products

Toxoplasma IgM

Detection System

Recommended Products

Assay Type

Solid Phase

Antigen

Mouse anti-human IgM, F(ab’)2 to Toxo & Rec. p30 antigen

Z01235M, C01523M and R01573 Z01235M, C01523M and 8200 Z01235M, C01523M and 8200 Z01235M, C01523M and 8200 W01259G, C01523M and 8200

Abbott ARCHITECT

CMIA IgM-capture sandwich method

Paramagnetic microparticles

Direct, CL

Abbott AxSYM

MEIA IgM-capture sandwich method

Microparticles Mouse anti-human IgM, MAb to Toxo p30 & native lysate Indirect, MUB

Siemens IMMULITE

CLIA IgM-capture sandwich method

Paramagnetic particles

Mouse anti-human IgM, MAb to Toxo & p30 antigen

Direct, CL

DiaSorin LIAISON

CLIA IgM-capture sandwich method

Paramagnetic particles

Mouse anti-human IgM, MAb to Toxo & native antigen Goat anti-human IgM, MAb to Toxo p30 & native antigen (RH Sabin strain)

Indirect, CL

BioMérieux VIDAS

ELFA IgM-capture sandwich method

Solid phase receptacles

Direct, MUB

Toxoplasma IgG

Detection System

Recommended Antigens

Assay Type

Solid Phase

Antigen

Abbott ARCHITECT ARCHITECT Avidity

Paramagnetic microparticles Paramagnetic microparticles

Rec. antigens to 30 and p35 (GRA8), anti-human IgG Rec. antigens to 30 and p35 (GRA8), anti-human IgG

CMIA

Indirect, CL R01573 and R01581

CMIA 2 assays with and without blocking buffer to dissociate low-avidity antibodies

Indirect, CL R01573 and R01581

Siemens AVIDA Centaur

Paramagnetic particles

CLIA

Native p30 antigen

Direct, CL

8200

Siemens IMMULITE 2000

Paramagnetic particles Paramagnetic microparticles Paramagnetic microparticles

Partially purified antigen, mouse anti-human IgG

CLIA

Indirect, CL 8200

DiaSorin LIAISON DiaSorin LIAISON Avidity

Native antigen, anti-human IgG Native antigen, anti-human IgG

CLIA

Indirect, CL 8200

CLIA 2 assays with and without a 6M urea elution step to dissociate low-avidity antibodies

Indirect, CL 8200

BioMérieux VIDAS BioMérieux VIDAS Avidity

Solid phase receptacles Solid phase receptacles

ELFA

Native antigen

Direct, MUB 8200

ELFA 2 assays (reference and test) with and without a disassociation wash step to remove low-avidity

Native antigen (RH Sabin strain), anti-human IgG

Direct, CL

8200

ELFA: Enzyme-linked fluorescence assay CLIA: Chemiluminescent Immunoassay CMIA: Chemiluminescent Microparticle Immunoassay MUB: Methyl-umbellifery CL: Chemiluminescence MEIA: Microparticle Enzyme Immunoassay ECLIA: Electrochemiluminescence Immunoassay

6 | ToRCH REAGENTS - IgG and IgM Assay Development

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