Infectious Diseases & Toxins

Infectious Diseases & Toxins Reagents for Assay Development ISO Certified 13485:2016

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Infectious Diseases Infectious diseases are a leading cause of death worldwide, particularly in low income countries and especially in young children. The leading killers are HIV/AIDS, tuberculosis and malaria, however, lower respiratory infections (including pneumonia) and diarrheal diseases are also 2 of the top 10 causes of death globally according to the most recent survey by the World Health Organization (WHO).

Infectious diseases can be caused by several different types of pathogenic organisms including viruses, bacteria, protozoa and fungi. Transmission can occur through several different mechanisms such as contact with aerosolized droplets or infected skin, ingestion of contaminated food and water, sexual contact or through specialized hosts called vectors (e.g. mosquitoes). The prevention and control of infectious diseases has been one of the principal public health activities of this century however they continue to pose a great health problem. New diseases are continuing to emerge and growing evidence also suggests that genetic changes in infectious agents are increasing their risk of causing serious diseases. Early diagnosis can play a critical role in preventing and controlling the spread of disease by reducing its morbidity and mortality. Traditional methodologies for diagnosing infectious diseases such as microbial or viral culture and microscopy, are continually being replaced by rapid and/or more sensitive alternatives such as immunoassays and molecular diagnostics. Rapid, point-of-care (POC) IVD tests that are easy to use have been largely sought after for their convenience, portability, and quick turn-around times allowing for faster decision making in regards to treatment and disease control. Diagnostic assays that directly identify an infectious agent have become increasingly essential to

THE TOP TEN LEADING CAUSES OF DEATH

Low income countries

High income countries Ischemic heart disease

Rank Worldwide

Ischemic heart disease

Lower respiratory infection

1

2 Stroke 3 COPD

HIV/AIDS

Stroke

Diarrheal diseases Lung Cancers

Lower respiratory infection

Alzheimer’s disease

4

Stroke

Ischemic heart disease

5 Lung Cancers

COPD

Lower respiratory infection

6 HIV/AIDS

Malaria

Diarrheal diseases

Preterm birth complications Tuberculosis

7

Colon Cancer

8 Diabetes

Diabetes

Birth asphyxia and trauma

Hypertensive heart disease

9 Road injury

Hypertensive heart disease

10

Malnutrition

Breast Cancer

Source: World Health Organization (2012)

managing patient treatment and preventing disease outbreaks.

Infectious Diseases & Toxins - Reagents for Assay Development II

Catalog Guide

Company Overview. ...................................................1 Tropical Diseases. .......................................................5 ToRCH & Childhood Diseases...................................10 Hepatitis....................................................................17 Sexually Transmitted Diseases (STDs)......................21 Respiratory Infections...............................................26 Gastrointestinal Diseases. ........................................35 Food & Water Safety Testing....................................42 Toxins & Biological Warfare. .....................................50 Veterinary & Animal Health.......................................54

III

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Company Overview

Meridian Life Science, Inc. is a leading large scale manufacturer of: • Antibodies • Viral antigens • Recombinant proteins • PCR enzymes • Nucleotides • Critical assay reagents Meridian has been providing innovative life science solutions and building trusted partnerships for over 40 years. Meridian’s focus is to offer products and services that help to advance the development of diagnostic assays and vaccine development. • Commercial scale manufacturing of antigens and antibodies with protein purification expertise • Full line of immunoassay reagents, including antigens, antibodies and blockers

• Large scale production of reagents for molecular assays • Technical support with assay development experience • Dedicated R&D and manufacturing teams • Robust and mature Quality System ISO certified

Infectious Diseases & Toxins - Reagents for Assay Development 1

Extensive Capabilities and Services Immunodiagnostics • A ntigens & Antibodies • Recombinant Proteins • Blocking reagents Molecular Diagnostics • Nucleotides • enzymes • qPCR/PCR reagents • NGS reagents Contract Services • A ntigens & Antibodies • C ell & Viral Banking • P CR/qPCR Assay Development

Global Presence

MERIDIAN BIOSCIENCE, INC. Parent Company | Founded in 1977 | Nasdaq: VIVO Headquartered in Cincinnati, OH | 750+ Employees | Presence in 70+ Countries.

North America

EMEA

Asia Pacific

SYDNEY, AUSTRALIA Warehouse & Sales BEIJING, CHINA Wholly Owned Subsidiary

MEMPHIS, TN Viral Antigens Recombinant Proteins In Vitro Antibodies PCR Reagents BILLERICA, MA

LONDON, UK PCR Manufacturing & Sales PCR /qPCR Molecular Reagents LUCKENWALDE, GERMANY Large Scale Nucleotides PCR Enzymes Manufacturing PARIS, FRANCE EU Diagnostics Sales & Admin WATERLOO, BELGIUM EU Diagnostics Sales & Admin MILAN, ITALY EU Diagnostics Sales & Admin MODI’IN, ISRAEL BreathID ® Breath Test Systems

Magellan, Leadcare BOCA RATON, FL In Vivo Antibodies QUEBEC, CANADA GenePOC, Molecular Diagnostics

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Company Overview

• 3400+ products • High specificity & sensitivity • Antibody pairing • Large lot sizes

Antigens & Antibodies

Infectious disease

ToRCH • Toxo • Rubella • CMV

CHILDHOOD • Mumps • Rubeola • EBV • Coxsackie • Rotavirus • RSV • Parvo B19 • VZV RESPIRATORY • RSV

• HSV-1, 2 TROPICAL • Nipah • Dengue 1, 2, 3, 4

• Chikungunya • Mayaro Virus • Malaria • Chagas • Lassa Virus

GASTROINTESTINAL • Norovirus • Astrovirus • Adenovirus • Rotavirus •  Clostridium difficile

FOOD & WATER • Hepatitis A •  Campylobacter jejuni •  E. coli •  Legionella pneumophila •  Salmonella •  Shigella •  Bacillus anthracis •  Clostridium •  Listeria •  Streptococcus •  Staphylococcus •  Giardia lamblia •  Cryptosporidium

• Leishmaniasis • Leptospirosis • Newcastle disease • Yellow Fever • Zika • Lyme disease • Ebola STDs

• Influenza A,B • Parainfluenza •  Mycoplasma pneumoniae •  Chlamydia pneumoniae •  Legionella pneumophila •  Mycobacterium tuberculosis •  Streptococcus •  Staphylococcus • SARS Coronavirus • Adenovirus

•  Cryptosporidium •  Campylobacter •  E. coli •  Salmonella •  Giardia Iamblia •  H. pylori HEPATITIS

• HSV-1, 2 • HIV-1, 2 • HPV • Chlamydia • Neisseria • Syphilis

• HAV • HBV • HCV • HEV

Infectious Diseases & Toxins - Reagents for Assay Development 3

Cancer

Cardiac

• PIVKA-II • CA125 • CA15-3 • CA19-9 • CA72-4 • CA50 • CA242 • CEA • Cyfra 21-1 • erbB-2/HER2 • AFP

• EGFR • HE4 • NSE • P53 • PMA

• Troponin I, T • Myoglobin • BNP • NT-proBNP • CRP • PCT • CK-MB • Apo A,B,E • NSE • FABP • SAH • Galectin-3

• Cystatin-C • D-Dimer • MPO • Fibrinogen • EGF • sCD40L • CD54 • Lp-PLA2 • PAPP-A • Vitamin D • Renin

• PAP • PSA

• PSMA • S-100 • B2M • Thyroglobulin

Immunoglobulins/Blockers

Hormones

• TRU Block™ & IgM Diluent • Animal IgGs – Bovine, Chicken, Goat, Mouse, Rabbit, Sheep • Human IgA, IgG, IgM, IgE

• LH, FSH, hCG, hGH • AMH • Cortisol, Estradiol • Insulin, C-peptide • Prolactin • Progesterone • PTH

• PAPP-A • TSH, T4, T3, ACTH • Thyroglobulin

• Kappa Light chain • Lambda Light chain • Goat Anti-Human IgG, IgM, IgA • Goat Anti-Mouse IgG

Drugs of Abuse • Amphetamine • Barbital • Benzodiazepine • Buprenorphine

• Fentanyl • Ketamine • K2 • MDMA (Ecstasy) • Methadone • Methamphetamine • Morphine

• Norketamine • Opium • Oxycodone • PCP • Phenobarbital • Propoxyphene • THC

• Cocaine • Cotinine • EDDP

Autoimmune

Allergens

• Jo-1 • PCNA • pANCA • cANCA • Sm Ag • dsDNA

• Histone • GMB • C1q • ScI-70 • B2-Gly-1

• Animal • Dust Mite • Mold • Pollen

• Cathepsin G • Calprotectin

• La (SS-B) • Ro (SS-A)

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Tropical & Vector-Borne diseases

Tropical and Vector-Borne diseases are among the most complex of all infectious diseases to prevent and control. Tropical diseases typically thrive in hot, humid conditions and include infections such as Malaria, Leishmaniosis, Dengue and Chagas. Many of these pathogens are also Vector-Borne diseases, transmitted between humans by a vector which is typically a blood-sucking arthropod (e.g. mosquitoes, ticks, fleas, lice and mites). Serological point-of-care (POC) diagnostics are the most rapid and convenient methods available for tropical and vector-borne diseases. Tests either detect antigens from the infectious agent or virus specific IgG/IgM antibodies and use formats such as solid-phase dip-sticks (ELISA), particle agglutination, and lateral flow. Ideally screening assays should have minimal cross-reactivity with other infectious diseases and have a high sensitivity, especially during the early stages of the infection. There have been numerous approaches used to improve the specificity of these assays including (1) using smaller and more specific regions (sub-units) of the epitopes; (2) using multiple antigens to different epitopes within a single assay; and (3) incorporating antigens which represent common genetic variations of the disease.

Antibody Pairs

C01914M C01913M CAPTURE DETECTION C01914M C01652M C01652M C01649M C01652M C01651M C01652M C01650M

CAPTURE DETECTION C01912M CO1906M C01912M CO1907M C01912M CO1911M C01912M CO1909M C01912M CO1910M CO1906M CO1911M CO1906M CO1907M CO1906M CO1909M CO1909M CO1911M CO1906M CO1910M CO1909M CO1910M CO1909M CO1907M CO1907M CO1911M CO1907M CO1910M CO1910M CO1911M

Dengue Virus NS1

Ebola Virus NP C01964M C01965M

Yellow Fever NS1

Nipah Virus G Protein

C01975M C01974M

Pan pLDH (Malaria)

C01834M C01835M

C01836M C01837M C01584M C01585M C01584M C01586M C01817M C01816M

P. falciparum (Malaria) HRP-2

P. falciparum pLDH (Malaria)

C01833M C01835M

C01887M C01888M C01887M C01889M C01888M C01888M C01888M C01890M C01889M C01888M C01867M C01868M

Antigen and Antibody

Zika Virus NS1

R01710 C01932M ANTIGEN ANTIBODY R01710 C01931M R01710 C01930M R01931M R01710 R01930M R01710

P. falciparum HRP-2 (Malaria)

Infectious Diseases & Toxins - Reagents for Assay Development 5

Full product list

Specificity

Catalog #

Type

Host

ALPHAVIRUS Alphavirus

C01643M MAb

Mouse

BORRELIA B. afzelii

R14210 R01707 R01576 R01609 R01526 B65302R B65303F B65304P B65307B

Ag Ag Ag Ag Ag

Broth E. coli E. coli E. coli E. coli Rabbit Rabbit Rabbit Rabbit Mouse E. coli E. coli E. coli E. coli E. coli E. coli E. coli E. coli E. coli E. coli E. coli E. coli E. coli E. coli Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse

B. afzelii

B. afzelii Osp-C B. afzelii VlsE

B. burgdorferi flagellin

B. burgdorferi B. burgdorferi B. burgdorferi B. burgdorferi

PAb PAb PAb PAb

B. burgdorferi Osp-A B. burgdorferi Osp-A B. burgdorferi Osp-C B. burgdorferi Osp-C B. burgdorferi VlsE B. garinii flagellin

C65550M MAb

R8A131 R01669 R8A123 R01523 R01521 R01610 R01436 R01587 R01671 R01684 R01685 R02001 R01589 R01364

Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag

B. garinii VlsE

CHAGAS (TRYPANOSOMA CRUZI) T. cruzi (Chagas) 1F8

T. cruzi (Chagas) 1F8 T. cruzi (Chagas) B13

T. cruzi (Chagas) chimeric 1 T. cruzi (Chagas) chimeric 2 T. cruzi (Chagas) chimeric 3

T. cruzi (Chagas) FRA

T. cruzi multiantigen Chimeric Chagas

CHIKUNGUNYA Chikungunya

C01640M MAb C01641M MAb C01642M MAb C01891M MAb C01892M MAb C01893M MAb C01894M MAb C01895M MAb

Chikungunya Chikungunya

Chikungunya Env. Chikungunya Env. Chikungunya Env. Chikungunya Env. Chikungunya Env.

Chikungunya Env. Proteins E1, E2, E3

R01768 R01703 R01704 R01654 R01653 R01711 R01702

Ag Ag Ag Ag Ag Ag Ag

Insect Cells

Chikungunya Capsid Chikungunya Capsid

E. coli E. coli

Chikungunya E1 Mutant Chikungunya E1 Wild-Type Chikungunya E1-E2 Wildtype

Insect Cells Insect Cells Insect Cells Insect Cells

Chikungunya E2

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Tropical & Vector-Borne diseases

Full product list continued

Specificity

Catalog #

Type

Host

DENGUE VIRUS Dengue Env.

C01896M MAb C01898M MAb C01899M MAb C01649M MAb C01650M MAb C01651M MAb C01652M MAb C01838M MAb C01913M MAb C01914M MAb C03045M MAb

Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Native

Dengue Env. Domain III of Serotypes 1-3 Dengue Env. Domain III of Serotypes 1-3

Dengue NS1 Dengue NS1 Dengue NS1 Dengue NS1 Dengue NS1 Dengue NS1 Dengue NS1

Dengue Types 1,2,3,4

Dengue Type 1 (Strain West Pacific 74) Dengue Type 1, Env. (a.a. 281-675) Dengue Type 1, Env. (a.a. 281-675) Dengue Type 1, NS1 (a.a. 777-1131) Dengue Type 1, NS1 (a.a. 777-1131) Dengue Type 2 (Strain 16681) Dengue Type 2, Env. (a.a. 281-675) Dengue Type 2, Env. (a.a. 281-675) Dengue Type 2, Env. N-Terminal Dengue Type 2, NS1 (a.a. 777-1131) Dengue Type 2, NS1 (a.a. 777-1131)

R01687 R01556 R01659 R01552 R01656 R02220 R01557 R01660 R01431 R01553 R01657 R01432 R01767 R01688 R01558 R01661 R01554 R01658 R01689 R01559 R01662 R01591 R01555 R01663

Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag

Drosophila Drosophila Drosophila Drosophila

Native

Drosophila Drosophila

E. coli

Drosophila Drosophila

Dengue Type 2, NS1

E. coli

Insect Cells

Dengue Type 2 premembrane (prM) Env. Dengue Type 3 (Strain CH53489) Dengue Type 3, Env. (a.a. 281-673) Dengue Type 3, Env. (a.a. 281-673) Dengue Type 3, NS1 (a.a. 775-1129) Dengue Type 3, NS1 (a.a. 775-1129) Dengue Type 4 (Strain TVP-360) Dengue Type 4, Env. (a.a. 280-674) Dengue Type 4, Env. (a.a. 280-674) Dengue Type 4, NS1 (a.a. 775-1126) Dengue Type 4, NS1 (a.a. 776-1130) Dengue Type 4, NS1 (a.a. 776-1130)

Native

Drosophila Drosophila Drosophila Drosophila

Native

Drosophila Drosophila

E. coli

Drosophila Drosophila

EBOLA Ebola Virus Ebola Virus Ebola Virus

C01762M MAb C86037M MAb C86180M MAb C01964M MAb C01965M MAb C01966M MAb C01967M MAb C01968M MAb C01969M MAb C01970M MAb C01971M MAb C01972M MAb C01973M MAb

Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse E. coli E. coli

Ebola Virus NP Ebola Virus NP Ebola Virus NP Ebola Virus NP Ebola Virus VP40 Ebola Virus VP40 Ebola Virus VP40 Ebola Virus VP40 Ebola Virus VP40 Ebola Virus VP40 Ebola Sudan NP Ebola Zaire NP

R01577 R01578

Ag Ag

Infectious Diseases & Toxins - Reagents for Assay Development 7

Specificity

Catalog #

Type

Host

JAPANESE ENCEPHALITIS (JEV) JEV

C01550M MAb

Mouse E. coli Mouse Mouse Mouse Mouse Mouse

JEV

R01435

Ag

JEV NS1 JEV NS1 JEV NS1 JEV NS1 JEV NS1

C01976M MAb C01977M MAb C01978M MAb C01979M MAb C01980M MAb

LASSA VIRUS Lassa Virus GP1 Protein LEISHMANIA L. chagasi K39 (a.a. 680-955)

R01787

Ag

Insect Cells

R01574 R01513

Ag Ag

E. coli E. coli

L. donovani KMP-11

LEPTOSPIRA BIFLEXA L. biflexa

B65401R

PAb

Rabbit

MARBURG VIRUS Marburg Virus

C01424M MAb C01425M MAb C01426M MAb C86103M MAb

Mouse Mouse Mouse Mouse

Marburg Virus Marburg Virus Marburg Virus

NEWCASTLE DISEASE VIRUS (NDV) NDV

C01352M MAb C86015M MAb C01629M MAb

Mouse Mouse Mouse

NDV

NDV Ribonucleoprotein

NIPAH VIRUS (NiV) NiV G Protein

C01974M MAb C01975M MAb

Mouse Mouse

NiV G Protein NiV G Protein

R01766

Ag

Insect Cells

PLASMODIUM (MALARIA) P. falciparum HRP-2

C01584M MAb C01585M MAb C01586M MAb C01816M MAb C01817M MAb C01836M MAb C01837M MAb C01930M MAb C01931M MAb C01932M MAb C86943M MAb

Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse E. coli E. coli E. coli E. coli Mouse Mouse E. coli E. coli E. coli

P. falciparum HRP-2 P. falciparum HRP-2 P. falciparum HRP-2 P. falciparum HRP-2 P. falciparum HRP-2 P. falciparum HRP-2 P. falciparum HRP-2 P. falciparum HRP-2 P. falciparum HRP-2 P. falciparum MSP1 P. falciparum HRP-2 P. falciparum HRP-2 P. falciparum MSP1 P. falciparum MSP1 P. falciparum MSP3 P. falciparum MSP4 P. falciparum MSP8 P. falciparum MSP9 P. falciparum MSP10

R01710 R01478 R01603 R01604

Ag Ag Ag Ag

C86634M MAb C86636M MAb

R01601 R01602 R01439

Ag Ag Ag

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Tropical & Vector-Borne diseases

Full product list continued

Specificity

Catalog #

Type

Host

P. falciparum pAldolase

R01595 R01597

Ag Ag

E. coli E. coli Mouse Mouse E. coli E. coli E. coli Mouse Mouse Mouse

P. falciparum pLDH P. falciparum pLDH

C01833M MAb C86328M MAb

P. vivax CSP P. vivax CSP P. vivax pLDH

R01440 R01598 R01596

Ag Ag Ag

Plasmodium HRP-2 Plasmodium pan pLDH Plasmodium pan pLDH Plasmodium pan pLDH

C01834M MAb C01835M MAb C66509M MAb

TICK-BORNE ENCEPHALITIS VIRUS Tick-borne Encephalitis Virus, gE

R18082

Ag

E. coli

WEST NILE VIRUS West Nile Virus Env. West Nile Virus Env. West Nile Virus Env.

C01538M MAb C01541M MAb C01542M MAb

Mouse Mouse Mouse E. coli E. coli Mouse Mouse Mouse Mouse Mouse Mouse Mouse

West Nile Virus Env. N-Terminal West Nile Virus Pre-M, N-Terminal

R8A104 R8A560

Ag Ag

YELLOW FEVER VIRUS Yellow Fever NS1

C01906M MAb C01907M MAb C01908M MAb C01909M MAb C01910M MAb C01911M MAb C01912M MAb

Yellow Fever NS1 Yellow Fever NS1 Yellow Fever NS1 Yellow Fever NS1 Yellow Fever NS1 Yellow Fever NS1 Yellow Fever NS1 Yellow Fever Env.

R01706 R01709

Ag Ag

Insect Cells Insect Cells

ZIKA VIRUS Zika Env.

C01860M MAb C01861M MAb C01862M MAb C01863M MAb C01937M MAb C01864M MAb C01865M MAb C01866M MAb C01867M MAb C01868M MAb C01869M MAb C01870M MAb C01887M MAb C01888M MAb C01889M MAb C01890M MAb

Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse

Zika Env. Zika Env. Zika Env. Zika Env. Zika NS1 Zika NS1 Zika NS1 Zika NS1 Zika NS1 Zika NS1 Zika NS1 Zika NS1 Zika NS1 Zika NS1 Zika NS1 Zika Env. Zika NS1 Zika NS1

R01635 R01636

Ag Ag

Insect Cells Insect Cells

C01885G C01886G

PAb PAb

Goat Goat

Zika NS1, Affinity Purified

Infectious Diseases & Toxins - Reagents for Assay Development 9

ToRCH & Childhood Diseases

ToRCH is an acronym for a group of infections that can cause congenital abnormalities and it has become an important part of prenatal care to recognize these infections in the first trimester of pregnancy.

Although the organisms typically cause only asymptomatic or mild infection to the mother, they can have much more serious consequences to the fetus. If the infection occurs during the first three months of pregnancy and if it is a primary infection (newly acquired during pregnancy), the risk of congenital abnormalities is much higher compared to a secondary or reactivated infection. An important part of prenatal care is to recognize these infections in the mother and the fetus and provide suitable care. ToRCH tests measure antibodies against five groups of chronic infections and all of these infectious diseases are associated with congenital abnormalities resulting from maternal infection: • Toxoplasmosis • Rubella • Cytomegalovirus (CMV) • Herpes simplex virus (HSV) • Other infections (usually Syphilis, Hepatitis B, Coxsackie virus, Epstein-Barr virus, Varicella-zoster virus, and Human parvovirus)

For most ToRCH organisms, the initial screening test is based on the detection of antibodies to the organism. Assays are commercially available for the detection of IgG, IgM, or both IgG and IgM antibodies. In most cases, IgG reactivity in the absence of IgM reactivity is indicative of a past infection, while IgM reactivity in the absence of IgG reactivity indicates a current infection. However, for some ToRCH diseases such as toxoplasmosis and CMV, IgG avidity has recently been found to be useful for identifying primary infections. An IgG antibody produced in the first few months following an initial infection has a lower avidity than an IgG antibody produced several months or years later. Consequently, low-avidity antibody can be used to specifically identify high-risk mothers with a primary infection. To protect a fetus from ToRCH infections, early diagnosis through first trimester screening is critical.

Antibody Pairs

CAPTURE DETECTION

C01686M C01688M C01686M

C01687M C01686M C01689M

Listeria

C01729M C01730M C65196M C65194M C65196M C65197M C65063M C65065M C01770M C01776M C01775M C01774M C01775M C01773M C01769M C01773M C01770M C01773M C01774M C01773M C65064M C65065M

Rotavirus

RSV

Antigen Pairs

CAPTURE DETECTION

T. pallidum (Syphilis)

R01681

R01682

R - Reversible

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ToRCH & Childhood Diseases

Full product list Specificity COXSACKIE Coxsackie A16 (G10 Strain) Coxsackie A9 (P.B. Bozek Strain) Coxsackievirus B1 (Tucson Strain) VP1

Catalog #

Type

Host

R17160 R17900 R01517

Ag Ag Ag

Native Native E. coli

CYTOMEGALOVIRUS (CMV) CMV (Strain AD 169)

B47821R

PAb

Rabbit Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Native E. coli E. coli Native Native Native E. coli E. coli E. coli E. coli E. coli E. coli E. coli E. coli E. coli Native Native Native Mouse E. coli E. coli E. coli E. coli E. coli E. coli Mouse Native Native E. coli E. coli E. coli Mouse Mouse Mouse Mouse Mouse

CMV Glycoprotein B CMV Glycoprotein B

C65826M MAb C8A024M MAb C86314M MAb C65089M MAb C65841M MAb C01245M MAb C8A023M MAb C8A022M MAb

CMV 65kDa EA CMV 65kDa LA CMV 70kDa IEA

CMV pp65 CMV pp65

CMV pp72 IEA CMV Antigen II CMV Chimeric 1

EV9268 R01686 R18102 EV7509

Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag

CMV Glycoprotein B (C194 Strain)

CMV Glycoprotein B CMV Grade III Antigen CMV (Strain AD 169)

7507 7600

CMV pp38 (UL80a) (Strain AD 169)

R18512 R01561 R01565 R18062 R18412 R01524 R01563 R01564 R18113

CMV pp52 (UL44) CMV pp52 (UL44) CMV pp52 (UL44)

CMV pp65 (UL83) (Strain AD 169)

CMV pp72 (UL123) CMV pp150 (UL32) CMV pp150 (UL32)

CMV pp150 (UL32) (Strain AD 169)

CMV-EXT-2, Concentrate

7517 7504 7511

CMV-G

CMV-M, Concentrate

ENTEROVIRUS Enterovirus 70

C01670M MAb

Enterovirus A Coxsackie A16

R01763 R01764 R01735 R01737 R01736 R01765

Ag Ag Ag Ag Ag Ag

Enterovirus A EV71 Enterovirus B Echo 18 Enterovirus B Cox B3 Enterovirus C Cox A24 Enterovirus D EV70

Enterovirus Pan-reactive VP3

C01700M MAb

EPSTEIN-BARR VIRUS (EBV) EBV

7420

Ag Ag Ag Ag Ag

EBV

R02100 R01672 R18740 R18230

EBV Epstein-Bar Nuclear Antigen-1

EBV (HHV-4) Early Antigen D

EBV (HHV-4) p23

EBV Early Antigen (BAM HI-Z) Zeta Protein

C65506M MAb C65502M MAb C65026M MAb C65221M MAb C65223M MAb

EBV Early Antigen (Restricted)

EBV Early Antigen-D

EBV gp220/350 EBV gp220/350

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Infectious Diseases & Toxins - Reagents for Assay Development

Specificity

Catalog #

Type

Host

EBV Latent Membrane Protein 2A EBV Nuclear Antigen-1 EBV Nuclear Antigen-1 EBV p138, Early Antigen D EBV p54, Early Antigen D EBV Viral Capsid Antigen gp125 EBV Viral Capsid Antigen p18 EBV Viral Capsid Antigen p23 EBV Viral Capsid Antigen EBV Viral Capsid Antigen gp125 HERPES SIMPLEX VIRUS (HSV) HSV Type 1

C01285R B65102G

MAb

Rat

PAb

Goat

R01522 R01525 R01575

Ag Ag Ag Ag Ag Ag

E. coli E. coli E. coli Native E. coli E. coli Mouse Mouse

8202

R01571 R01570

C65023M MAb C66405M MAb

B65131G B65133G B65134G B65121S B65123S B65124S

PAb PAb PAb PAb PAb PAb

Goat Goat Goat

HSV Type 1 HSV Type 1 HSV Type 2 HSV Type 2 HSV Type 2 HSV Type 1 HSV Type 1 HSV Type 1

Sheep Sheep Sheep Mouse Mouse Native Native E. coli

C01290M MAb C01291M MAb

7305 7309

Ag Ag Ag Ag

HSV Type 1 Concentrate HSV Type 1 Glycoprotein D HSV Type 1 Glycoprotein D HSV Type 1 Glycoprotein C HSV Type 1 Glycoprotein D HSV Type 1 Glycoprotein E HSV Type 1 Glycoprotein G HSV Type 1 Glycoprotein G-1

R18430 VTI510

P. pastoris

C65141M MAb C8A020M MAb C65120M MAb

Mouse Mouse Mouse

VTI520

Ag

S. cerevisiae

C66150M MAb

Mouse Mouse Mouse Native Native

HSV Type 1 Nucleocapsid Protein (155kDa)

C05014MA

MAb

HSV Type 2 HSV Type 2

C01292M MAb

7705 7749

Ag Ag Ag Ag

HSV Type 2 Concentrate HSV Type 2 Glycoprotein D HSV Type 2 Glycoprotein D HSV Type 2 Glycoprotein D HSV Type 2 Glycoprotein D HSV Type 2 Glycoprotein E HSV Type 2 Glycoprotein G-2 HSV Type 2 Glycoprotein G-2 HSV Type 2 Glycoprotein G HSV Type 2 Glycoprotein G HSV Type 2 Glycoprotein G HSV Type 2 Glycoprotein G HSV Type 2 Glycoprotein G

VTI540 R18530

P. pastoris

E. coli Mouse Mouse Mouse Mouse Mouse Mouse E. coli

C86302M MAb C01859M MAb C65901M MAb C66501M MAb C66516M MAb C65116M MAb

R18350 VTI530 EV9287 R01673 B65107R B65205R

Ag Ag Ag Ag

S. cerevisiae

Native E. coli Rabbit Rabbit Mouse Mouse

HSV Types 1 & 2 HSV Types 1 & 2

PAb PAb

HSV Types 1 & 2 Glycoprotein D HSV Types 1 & 2 Glycoprotein D HUMAN HERPES VIRUS (HHV) HHV Type 6 37kDa EA

C01294M MAb C65912M MAb

C65206M MAb C65020M MAb C65200M MAb

Mouse Mouse Mouse

HHV Type 6 gp60/110

HHV Type 6 p150

12

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ToRCH & Childhood Diseases

Full product list continued

Specificity

Catalog #

Type

Host

LISTERIA L. flagella

C01917M MAb

Mouse

Listeria

G5V99-500 A01710N B65420B B65420F B65420P B65420R

PAb

Goat

L. monocytogenes L. monocytogenes L. monocytogenes L. monocytogenes L. monocytogenes

Ag

Culture Rabbit Rabbit Rabbit Rabbit Mouse Mouse Mouse Mouse

PAb PAb PAb PAb

L. monocytogenes P60 L. monocytogenes P60 L. monocytogenes P60 L. monocytogenes P60

C01686M MAb C01687M MAb C01688M MAb C01689M MAb

LYMPHOCYTIC CHORIOMENINGITIS VIRUS (LCMV) LCMV

C44104M MAb

Mouse

MUMPS Mumps Grade III

EV9529

Ag Ag

Native Native Mouse Mouse Mouse E. coli E. coli E. coli E. coli E. coli E. coli

Mumps Virus

8099

Mumps Virus (NP) Mumps Virus (NP) Mumps Virus (NP) PARVOVIRUS Parvovirus B19 NS1 Parvovirus B19 VP1

C01719M MAb C01720M MAb C01721M MAb

R01637 R01638 R01640 R01642 R01643 R01641 R01639 R01644

Ag Ag Ag Ag Ag Ag Ag Ag

Parvovirus B19 VP1 (a.a. 1-230) Parvovirus B19 VP1 (a.a. 1-486)

Parvovirus B19 VP1 (a.a. 313-781) Parvovirus B19 VP1/VP2 (a.a. 485-781)

Parvovirus B19 VP2

Sf9 Cells

Parvovirus B19 VP2 (a.a. 233-781)

E. coli Mouse

Parvovirus B19 VP2

C01718M MAb

POLIOVIRUS Poliovirus 1

C30510M MAb C30027M MAb

Mouse Mouse

Poliovirus 3

RESPIRATORY SYNCYTIAL VIRUS (RSV) RSV

B65820G B65830G B65840G B65860G

PAb PAb PAb PAb

Goat Goat Goat Goat

RSV RSV RSV

RSV (NP) RSV (NP) RSV (NP) RSV (NP) RSV (NP)

C01287M MAb

Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse

C65067F

MAb

C65067M MAb C66432M MAb C87320M MAb C01769M MAb C01770M MAb C01771M MAb C01772M MAb C01773M MAb C01774M MAb C01775M MAb

RSV Fusion Protein RSV Fusion Protein RSV Fusion Protein RSV Fusion Protein RSV Fusion Protein RSV Fusion Protein RSV Fusion Protein

13

Infectious Diseases & Toxins - Reagents for Assay Development

Specificity

Catalog #

Type

Host

RSV Fusion Protein RSV Fusion Protein RSV Fusion Protein RSV Fusion Protein RSV Fusion Protein RSV Fusion Protein RSV Fusion Protein

C01776M MAb C01777M MAb C65063M MAb C65064M MAb C65065M MAb C65816M MAb C87610M MAb

Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Native Native

RSV Fusion Protein (46kDa & 22kDa S-S linked glycoprotein) C01286M MAb

RSV Fusion Protein, Type A and B Strains

C01626M MAb C01694M MAb C86001M MAb

RSV Long Strain RSV Long Strain RSV Long Strain RSV Long Strain

R29124 R86900

Ag Ag Ag

RSV Antigen (Long Strain) >10% Viral Protein

8175

FRhK Cells

ROTAVIRUS Rotavirus

C01729M MAb C01730M MAb C65194M MAb C65196M MAb C65197M MAb C65521M MAb C01295M MAb C66130M MAb C86310M MAb

Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse E. coli Mouse

Rotavirus Rotavirus Rotavirus Rotavirus

Rotavirus broad reactivity

Rotavirus Group A Specific Antigen, (Vp6) Rotavirus Group A Specific Antigen, (Vp6)

Rotavirus Group Specific Antigen

Rotavirus (Vp6) Rotavirus (Vp7)

R01728

Ag

C01715M MAb

Rotavirus (Nebraska Calf Diarrhea Virus)(all antigens) Rotavirus (Nebraska Calf Diarrhea Virus)(all antigens) Rotavirus (Nebraska Calf Diarrhea Virus)(all antigens) Rotavirus (Nebraska Calf Diarrhea Virus)(all antigens)

B65110G B65211G B65212G B65213G B01235S

PAb PAb PAb PAb PAb

Goat Goat Goat Goat

Rotavirus (all serotypes)

Sheep Native

Rotavirus SA-11

7844

Ag

RUBELLA Rubella (Virions) Rubella (Virions) Rubella (Virions)

B65105G B65703F B65704P EV9526

PAb PAb PAb

Goat Goat Goat

Rubella (Clone 2-42) Rubella (Clone 2-6) Rubella Capsid (C)

MAb MAb

Mouse Mouse Mouse Mouse Mouse Mouse

EV9525

C66496M MAb C66499M MAb C66503M MAb C86323M MAb

Rubella E1 Rubella E1

Rubella Virus E1

Rubella Virus, Purified, Strain HPV-77

9601

Ag Ag Ag Ag Ag Ag Ag Ag Ag

Vero Cells

Rubella Virus E1 Mosaic Rubella Virus E1 Mosaic

R01491 R18192 R18292 R18092

E. coli E. coli E. coli E. coli Native Native Native Native

Rubella Virus E2 Rubella Capsid (C)

Rubella IgM MAX TM Rubella Virus Grade III Rubella Virus Grade IV

6200 6075 6076 6123

Rubella Virus Grade IV PBS

14

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ToRCH & Childhood Diseases

Full product list continued

Specificity

Catalog #

Type

Host

RUBEOLA (MEASLES) Rubeola

C01723M MAb C01724M MAb C01725M MAb C01726M MAb

Mouse Mouse Mouse Mouse Native Native

Rubeola Rubeola Rubeola Rubeola

7604

Ag Ag Ag

Rubeola (Edmonston Strain)

R14120 EV9298

Rubeola (NP)

Sf9 Cells

STREPTOCOCCUS Streptococcus Group B Streptococcus Group B Streptococcus Group B TOXOPLASMA GONDII T. gondii (tachyzoites)

B65524P B65527B B65527R

PAb PAb PAb

Rabbit Rabbit Rabbit

B01438R

PAb

Rabbit Mouse Mouse Mouse Mouse Mouse Native Native Native E. coli E. coli E. coli E. coli Rabbit Rabbit Rabbit Rabbit Mouse Mouse E. coli E. coli E. coli E. coli Mouse E. coli E. coli E. coli E. coli Mouse Mouse E. coli E. coli E. coli E. coli Mouse

T. gondii

C86319M MAb C01589M MAb C01587M MAb C65620M MAb C01523M MAb

T. gondii (38kDa protein)

T. gondii (MIC3)

T. gondii p30 (SAG1)

T. gondii (SAG1)

T. gondii (RH Strain)

8200 8158 8159

Ag Ag Ag Ag Ag Ag Ag

T. gondii (RH Strain) Concentrated

T. gondii

T. gondii p29 (GRA7) T. gondii p30 (SAG1) T. gondii p30 (SAG1) T. gondii p35 (GRA8)

R18306 R01573 R18426 R01581

TREPONEMA PALLIDUM (SYPHILIS) T. pallidum

B65210B B65210F B65210P B65210R

PAb PAb PAb PAb

T. pallidum T. pallidum T. pallidum T. pallidum

C65811M MAb

T. pallidum and T. reiter

C01706M

MAb

T. pallidum p15 T. pallidum p15 T. pallidum p15

R01531 R01582 R8A101 R01681 R01682 R01497 R01528 R01583 R8A201

Ag Ag Ag Ag Ag Ag Ag Ag Ag

T. pallidum p15/p17/p47 T. pallidum p15/p17/p47

T. pallidum p17 T. pallidum p17 T. pallidum p17 T. pallidum p17 T. pallidum p17 T. pallidum p17

C01705M MAb C01707M MAb

T. pallidum p17/p15/p44.5/p47

R01705 R01529 R18044 R18830

Ag Ag Ag Ag

T. pallidum p41 T. pallidum p41 T. pallidum p41 T. pallidum p47

C01261M MAb

15

Infectious Diseases & Toxins - Reagents for Assay Development

Specificity

Catalog #

Type

Host

T. pallidum p47

C01263M MAb

Mouse E. coli E. coli E. coli E. coli E. coli E. coli E. coli Mouse Mouse Mouse Mouse Mouse Mouse Mouse Native

T. pallidum p47, mosaic of immunodominant regions

R01568 R01606 R8A403

Ag Ag Ag Ag Ag Ag Ag

T. pallidum p47 T. pallidum p47

T. pallidum , Treponemal Membrane Protein A Full Length R01632

T. pallidum , Treponemal Membrane Protein A T. pallidum , Treponemal Membrane Protein A T. pallidum , Treponemal Membrane Protein A

R01530 R01665 R8A404

VARICELLA ZOSTER VIRUS (VZV) VZV (gpI & IV) (VZVgE & gI)

C05100MA C05101MA C05102MA C05104MA C05105MA C05108MA C05107MA

MAb MAb MAb MAb MAb MAb MAb

VZV (gpI & IV) (VZVgE & gI)

VZV (gpII) (VZVgB) VZV (gpIII) (VZVgH) VZV (gpIV) (VZVgI)

VZV (Mixed)

VZV 175kDa, gene 62

VZV

7209

Ag Ag Ag Ag Ag

VZV gE (Ellen Strain)

R18330 R14041

E. coli

VZV Glycoprotein (Ellen Strain)

HEL Cells

VZV II

7740 7201

Native Native

VZV PBS

ZIKA VIRUS Zika Virus Env. Zika Virus Env. Zika Virus Env Zika Virus Env. Zika Virus Env. Zika Virus Env. Zika Virus NS1 Zika Virus NS1 Zika Virus NS1 Zika Virus NS1 Zika Virus NS1 Zika Virus NS1 Zika Virus NS1 Zika Virus NS1 Zika Virus NS1 Zika Virus NS1 Zika Virus NS1 Zika Virus NS1 Zika Virus NS1

R01635

Ag

Insect Cells

C01860M MAb C01861M MAb C01862M MAb C01863M MAb C01937M MAb C01864M MAb C01865M MAb C01866M MAb C01867M MAb C01868M MAb C01869M MAb C01870M MAb C01887M MAb C01888M MAb C01889M MAb C01890M MAb

Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse

R01636

Ag

Insect Cells

C01885G C01886G

PAb PAb

Goat Goat

Zika Virus NS1, Affinity Purified

16

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Hepatitis

Hepatitis refers to an inflammatory condition of the liver. It is commonly caused by a viral infection from one of five unrelated hepatotropic viruses: hepatitis A (HAV), hepatitis B (HBV), hepatitis C (HCV), hepatitis D (HDV) and hepatitis E (HEV). HAV is an acute, short-term disease, which is commonly transmitted by consuming food or water contaminated by feces from an infected person. HBV and HCV are transmitted through direct contact with infectious body fluids such as blood, or semen, and typically lead to an ongoing, chronic form of liver disease. HDV is a rare form of hepatitis that only occurs in conjunction with HBV infection as the virus cannot multiply without the presence of HBV. HEV is a waterborne disease mainly found in areas with poor sanitation and typically results from ingesting fecal matter that contaminates the water supply. The disease is usually acute but can be particularly dangerous in pregnant women. Viral hepatitis is primarily diagnosed through blood tests for levels of viral antigens, anti-viral antibodies, or viral DNA/RNA. Overall, hepatitis causes more than a million deaths a year, most of which occur indirectly from liver scarring or liver cancer.

Antibody Pairs

CAPTURE DETECTION C86317M C86340M C01556M C01558M C01556M C01557M C86743M C86334M C86843M C86534M C65218M C65318M C65218M C65814M C01693M C01692M C01549M C01548M

C86312M C86600M C86322M C86600M C86612M C86600M C86612M C86322M C01251M C01252M C01251M C01253M C01252M C65317M C01253M C65317M R01599 R01600 C01248M B65811P C01465M C01457M C01458M C01465M CAPTURE DETECTION C01246M C01249M C01246M C01250M C01246M B65811P C01247M B65811P C18212M C18286M C01247M C01249M C01248M C01249M

Hepatitis B Virus Core Antigen (HBcAg)

Hepatitis B Surface Antigen (ad/ay) (HBsAg)

Hepatitis B ‘e’ Antigen (HBeAg)

Hepatitis B Surface Antigen (HBsAg)

C86303M C86401M

Hepatitis B Surface Antigen (ayw) (HBsAg)

Hepatitis C Virus (HCV) Core Antigen

17

Infectious Diseases & Toxins - Reagents for Assay Development

Full product list

Specificity

Catalog #

Type

Host

HEPATITIS A VIRUS (HAV) HAV

C01853M MAb C01854M MAb C01855M MAb C65881M MAb C65885M MAb

Mouse Mouse Mouse Mouse Mouse

HAV HAV HAV

HAV Surface Protein HAV Strain HM175 HAV >60% Viral Protein

B65808G

PAb

Goat

8198 8505

Ag Ag Ag Ag Ag

FRhK-4 Cells FRhK-4 Cells

HAV Concentrate, >60% Viral Protein

HAV VP1

R18710 R18810 R18610

E. coli E. coli E. coli

HAV VP1-P2A

HAV VP3

HEPATITIS B CORE ANTIGEN (HBCAG) HBcAg

C01556M MAb C01557M MAb C01558M MAb C86317M MAb C86340M MAb C8A035M MAb C8A036M MAb C8A038M MAb

Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse E. coli E. coli E. coli

HBcAg HBcAg HBcAg HBcAg

HBcAg (ayw) (~80 a.a.) HBcAg (ayw) (a.a. 1-10) HBcAg (ayw) (a.a. 130-140) HBcAg (ayw) (a.a. 135-140) HBcAg (ayw) (a.a. 138-145) HBcAg (ayw) (a.a. 70-80) HBcAg (184 a.a.) 19kDa HBcAg (a.a. 1-144) 14kDa HBcAg (a.a. 1-183) 18kDa

C8A034B

MAb

C8A037M MAb C8A033M MAb

R65914 R8A100 R8A120 VTI610

Ag Ag Ag Ag

HBcAg (183 a.a.)

P. pastoris

HEPATITIS B ‘E’ ANTIGEN (HBEAG) HBeAg

C01548M MAb C01549M MAb C01692M MAb C01693M MAb C31170M MAb C65218M MAb C65318M MAb C65814M MAb C86334M MAb C86534M MAb C86743M MAb C86843M MAb

Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse E. coli E. coli E. coli Mouse Mouse Mouse Mouse Mouse Mouse

HBeAg HBeAg HBeAg HBeAg HBeAg HBeAg HBeAg HBeAg HBeAg HBeAg HBeAg

HBeAg (160 a.a.) 17kDa

R65915 R01401 R18915

Ag Ag Ag

HBeAg HBeAg

HEPATITIS B SURFACE ANTIGEN (HBSAG) HBsAg

C01815M MAb C86303M MAb C86401M MAb C86612M MAb

HBsAg HBsAg HBsAg HBsAg

MAV18-511

MAb

HBsAg (ad)

C45098M MAb

18

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Hepatitis

Full product list continued

Specificity

Catalog #

Type

Host

HBsAg (ad) HBsAg (ad) HBsAg (ad)

R01437 R01507 R01289

Ag Ag Ag

Human Plasma

Human

S. cerevisiae

HBsAg

B01435G B65811B B65811F B65811R B65811P B65180G B65803F B65804P B65807B

PAb PAb PAb PAb PAb PAb PAb PAb PAb

Goat

HBsAg (ad/ay) HBsAg (ad/ay) HBsAg (ad/ay) HBsAg (ad/ay) HBsAg (ad/ay) HBsAg (ad/ay) HBsAg (ad/ay) HBsAg (ad/ay) HBsAg (ad/ay) HBsAg (ad/ay) HBsAg (ad/ay) HBsAg (ad/ay) HBsAg (ad/ay) HBsAg (ad/ay) HBsAg (ad/ay) HBsAg (ad/ay) HBsAg (ad/ay) HBsAg (ad/ay) HBsAg (ad/ay) HBsAg (ad/ay) HBsAg (ad/ay) HBsAg (ad/ay) HBsAg (ad/ay) HBsAg (adr) HBsAg (adw) HBsAg (adw) HBsAg (adw) HBsAg (ayw) HBsAg (ayw) HBsAg (ayw) HBsAg (ayw)

Rabbit Rabbit Rabbit Rabbit

Goat Goat Goat Goat

C01455M MAb C01456M MAb C45100M MAb C92100M MAb C01246M MAb C01247M MAb C01248M MAb C01249M MAb C01250M MAb C01457M MAb C01458M MAb C01465M MAb C18212M MAb C18286M MAb

Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Horse

B03504C R01652 R01403 R18560 R86872

Ag Ag Ag Ag Ag

CHO Cells P. pastoris P. pastoris

S. cerevisiae

C86312M MAb C86313M MAb C86322M MAb C86600M MAb C8A032M MAb C45704M MAb

Mouse Mouse Mouse Mouse Mouse Mouse Mouse Human

HBsAg (adw/ayw)

HBsAg (ay) HBsAg (ay) HBsAg (ay) HBsAg (ay) HBsAg (ayw)

MAV18-004

MAb

R01508 R01290 R86870

Ag Ag Ag

S. cerevisiae S. cerevisiae

HEPATITIS B Hepatitis B Presurface S1 (108 a.a.) 13.5kDa

R65913 R01579 R01580

Ag Ag Ag

E. coli E. coli E. coli Mouse Mouse Mouse Mouse

Hepatitis B Presurface S1+S2 Hepatitis B Presurface S2

Hepatitis B Presurface (adw) (a.a. 132-137)

C8A031M MAb C01766M MAb C01767M MAb C01768M MAb

Hepatitis B X Antigen Hepatitis B X Antigen Hepatitis B X Antigen

19

Infectious Diseases & Toxins - Reagents for Assay Development

Specificity

Catalog #

Type

Host

HEPATITIS C VIRUS (HCV) HCV Core Antigen

C11423M MAb C65185M MAb

Mouse Mouse Mouse Mouse Mouse

HCV Core Antigen

HCV Core Antigen (a.a. 1-80) HCV Core Antigen (a.a. 1-80) HCV Core Antigen (a.a. 1-80) HCV Core Antigen (a.a. 1-120) HCV Core Antigen (a.a. 2-192) HCV Core Antigen (a.a. 33-38) HCV Core Antigen (a.a. 70-90) HCV Core Antigen (a.a. 80-120) HCV Core Antigen 1a and 2 HCV Core Antigen 1a and 2

C8A016B C8A016F

MAb MAb

C8A016M MAb

B65168G

PAb

Goat

C8A117M MAb C65317M MAb C8A216M MAb

Mouse Mouse Mouse Mouse Mouse Mouse Mouse E. coli E. coli E. coli E. coli E. coli E. coli

C8A017B

MAb

C01251M MAb C01252M MAb C01253M MAb

HCV Core Antigen Genotypes 1a and 2 HCV Core Antigen (a.a. 2-120) Genotype 1

R18140 R8A115 R01599 R01600 R8A442 R01518 B01437G

Ag Ag Ag Ag Ag Ag

HCV Core Antigen (a.a. 2-192) HCV Core NS3/NS4/NS5 HCV Core NS3/NS4/NS5 HCV NS-3 (a.a. 1450-1643)

HCV NS-3 c33c (a.a. 1192-1459) Genotype 1a

HCV E1 HCV E1 HCV E2

PAb

Goat

C65198M MAb C65167M MAb

Mouse Mouse

HCV E2 (a.a. 384-665)

B65581G

PAb

Goat

HCV NS-3

C65371M MAb C65859M MAb C8A217M MAb

Mouse Mouse Mouse

HCV NS-3 Region (a.a. 1252-1477) HCV NS-3 Region (a.a. 1350-1460)

HCV NS-3 Region

B65178G

PAb

Goat

HCV NS-3 c33c (a.a. 1192-1459) Subtype 1a HCV NS-3 c33c (a.a. 1192-1459) Subtype 2b

R18358 R18800 R01234 R18541

Ag Ag Ag Ag

E. coli E. coli E. coli E. coli

HCV NS-3, C-Terminal

HCV NS-4

HCV NS-4 Region

B65188G C8A018F

PAb

Goat

HCV NS-4 Region (Recomb. & Native) HCV NS-4 Region (Recomb. & Native) HCV NS-4a Region (a.a. 1700-1710) HCV NS-4b Region (a.a. 1710-1730) HCV NS-4a+b Antigen (a.a. 1658-1863) HCV NS-5 (a.a. 2212-2313) Genotype 1 HCV NS-5 (a.a. 2322-2423) Genotype 1a

MAb

Mouse Mouse Mouse Mouse E. coli E. coli E. coli Mouse Mouse E. coli

C8A018M MAb C8A236M MAb C8A246M MAb

R8A116 R18190 R18206

Ag Ag Ag

HCV NS-5a Region

C65388M MAb C8A256M MAb

HCV NS-5a Region (a.a. 2190-2300) HCV Nucleocapsid NS3/NS4/NS5

R18523 VTI710

Ag Ag

HCV Nucleocapsid Protein

P. pastoris

HEPATITIS D VIRUS (HDV) HDV HEPATITIS E VIRUS (HEV) HEV ORF2 and ORF3 HEV ORF2 (a.a. 403-461) HEV ORF2 (a.a. 633-659) HEV ORF3 (a.a. 92-123)

R18420

Ag

E. coli

R18250 R8A330 R8A310 R8A320

Ag Ag Ag Ag

E. coli E. coli E. coli E. coli

20

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Sexually Transmitted Diseases (STDs)

Sexually transmitted diseases (STDs) are a major global cause of acute illness, infertility, long-term disability and death, with serious medical and psychological consequences to millions of men, women and infants. Today, over 30 bacterial, viral and parasitic pathogens have been identified that can be transmitted sexually.

STDs are generally acquired by sexual contact specifically through blood, semen, or vaginal and other bodily fluids. Many STDs (chlamydia, gonorrhea, hepatitis, HIV, papillomavirus, Herpes Simplex Virus and syphilis) can also be transmitted non-sexually such as from mother to infant during pregnancy or childbirth, or through blood transfusions, or shared needles. Many STDs have no symptoms, therefore an infection may go unnoticed until complications occur. STDs rank among the top five disease categories for which adults seek health care. Early and rapid diagnosis of STDs increases the chance to limit effects of the disease. Since many people infected by a STD have few or no symptoms of their infection, they put others (including unborn children from pregnant mothers) at risk. There are five main methods for the diagnosis of STDs which include (1) culture (2) microscopy (3) detection of antigens or enzymes (4) detection of nucleic acid sequences (NAAT) and (5) detection of antibodies. Of the five approaches, the assays that provide the most rapid diagnosis have gained the most acceptance. As a result, this has largely limited the traditional use of culture and increased development efforts on rapid tests using microscopy (detection of antibodies by rapid serologic methods, and specific detection of cellular components, including antigens, enzymes, or nucleic acid sequences (especially with amplification).

Antibody Pairs

R01625 R01626 R01631 R01626 C65499M C01653M C01657M C65499M C01655M C65690M C01657M C01655M C65690M C01653M C01655M C01653M C01657M C65690M C01656M C65690M C65941M C65690M C11999M C11998M C01655M C01656M CAPTURE DETECTION C01566M C01565M

C. trachomatis

Human Immunodeficiency Virus Type I (HIV-1)

Human Papilloma Virus (HPV) Type 11 E7 Protein Human Immunodeficiency (HIV) Chimeric Human Papilloma Virus (HPV) Type 18 E7 Protein Human Papilloma Virus (HPV) Type 16 E7 Protein

C86166M C86913M

C86718M C86238M C86867M C86238M C86791M C86789M C86791M C86238M

C01571M C01569M

T. vaginalis

R - Reversible

21

Infectious Diseases & Toxins - Reagents for Assay Development

Full product list

Specificity

Catalog #

Type

Host

CHLAMYDIA Chlamydia species LPS Chlamydia species LPS Chlamydia species LPS

C65168M MAb C65815M MAb

Mouse Mouse Mouse Mouse

MAV07-347

MAb

C. trachomatis

C66435M MAb

C. trachomatis (EB's all antigens) C. trachomatis (EB's all antigens) C. trachomatis (EB's all antigens) C. trachomatis (EB's all antigens) C. trachomatis (EB's all antigens)

B65252G B65252R B65253R B65256G B65256R B65261G B65266G

PAb PAb PAb PAb PAb PAb PAb

Goat

Rabbit Rabbit

Goat

Rabbit

C. trachomatis (MOMP) C. trachomatis (MOMP) C. trachomatis (MOMP) C. trachomatis (MOMP) C. trachomatis (MOMP)

Goat Goat

C01363M MAb C65166M MAb

Mouse Mouse Mouse Mouse Mouse Mouse

MAV06-086

MAb

C. trachomatis and C. psittaci

C66436M MAb C01565M MAb C01566M MAb

C. trachomatis LPS C. trachomatis LPS

C. trachomatis LGV Type-2 (Strain 434) Elementary Bodies (EB) R02121

Ag

Mouse L Cells

HCV Core Antigen 1a and 2 HCV Core Antigen 1a and 2

C01251M MAb C01252M MAb C01253M MAb

Mouse Mouse Mouse E. coli Insect E. coli E. coli E. coli E. coli E. coli E. coli E. coli

HCV Core Antigen Genotypes 1a and 2 HCV Core Antigen (a.a. 2-120) Genotype 1 HUMAN IMMUNODEFICIENCY VIRUS (HIV) HIV-1 p24

R18140

Ag

R01785 R01625 R01626 R01631 R65908 R8A113 R01633 R01454 B65961B B65961G B65961P B65873G B65875G B65971G

Ag Ag Ag Ag Ag Ag Ag Ag

HIV Chimeric gp120 and gp41 HIV Chimeric gp120 and gp41 HIV Chimeric gp120 and gp41

HIV Type 1 gp41 Env.

HIV Type 1 gp41 Env. (a.a. 466-753)

HIV Type 1 gp41

HIV Type 1 gp41 Type O

HIV Type 1 gp120 HIV Type 1 gp120 HIV Type 1 gp120

PAb PAb PAb PAb PAb PAb

Goat Goat Goat Goat Goat Goat

HIV Type 1 (purified virions) HIV Type 1 (purified virions)

HIV Type 1 gp41

HIV Type 1 gp120 + most of gp41, C-Terminal HIV Type 1 gp120 + most of gp41, C-Terminal

R01593 R18550 R01276 R01532

Ag Ag Ag Ag

E. coli E. coli E. coli E. coli Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse Mouse

HIV Type 1 gp120 (v3 loop region) HIV Type 1 gp160 (a.a. 283-674)

HIV Type 1 gp41 HIV Type 1 gp41 HIV Type 1 gp41 HIV Type 1 p17 HIV Type 1 p24 HIV Type 1 p24 HIV Type 1 p24 HIV Type 1 p24 HIV Type 1 p24 HIV Type 1 p24

C18812M MAb C65911M MAb C8A015M MAb C8A014M MAb C01653M MAb C01655M MAb C01656M MAb C01657M MAb C11998M MAb C11999M MAb

22

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