Cancer & Tumor Markers Catalog

Cancer & Tumor Markers Reagents for Assay Development ISO Certified 13485:2016

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Company Overview

Extensive Capabilities & Services

Molecular Reagents qPCR | RT-qPCR | LAMP

Immuno Reagents Antigens | Antibodies | Blockers

ENZYMES • Hot-Start Taq technologies - chemical, antibody, aptamer • Lyo & Air-Dryable enzymes (glycerol free) Taq, Bst, RTase • Thermostable MMLV RT MASTER MIXES • Lyo & Air-Dryable formats • Inhibitor-tolerant mixes for stool, sputum, saliva, blood, plant, water. • For multiplexing, GC-rich templates

VIRUS MANUFACTURING • Live or inactivated • Proprietary Ag purification

RECOMBINANT PROTEINS •  E. coli, P. pastoris, S. cerevisiae , Sf9, Mammalian (CHO, HEK293) • 10L- 130L fermentation ANTIBODIES – MAbs/PAbs • 500+ MAbs produced in grams • Multi-Kilograms of MIgG / year • Hundreds of liters of GxhIgG • Ascites production (55,000 Mice)

NUCLEOTIDES • dNTPs, Na or Li salts • Ultra high purity, >99%

Cancer & Tumor Markers - Reagents for Assay Development II

Commercial scale manufacturing of antigens and antibodies with protein purification expertise.

Meridian has been providing innovative life science solutions and building trusted partnerships for over 43 years. Meridian’s focus is to offer complete solutions for the development of molecular and immunological assays.

• Full line of immunoassay reagents, including antigens, antibodies and blockers • Large scale production of reagents for molecular assays • Technical support with assay development experience • Dedicated R&D and manufacturing teams • Robust and mature Quality System

ISO Certified 13485:2016

Global presence

WATERLOO, Belgium

LONDON, United Kingdom

QUEBEC, Canada

LUCKENWALDE, Germany

BILLERICA, MA

MANASQUAN, NJ

BEIJING, China

PARIS, France

CINCINNATI, OH (Headquarters)

CHANGZHOU, China

MILAN, Italy

MEMPHIS, TN

BOCA RATON, FL

MODIIN, Israel

SYDNEY, Australia

Diagnostic Manufacturing | Life Science Manufacturing | Sales & Warehouse

MERIDIAN BIOSCIENCE, INC. Parent Company | Founded in 1977 | Nasdaq: VIVO | 750+ Employees Headquartered in Cincinnati, OH | Presence in 70+ Countries.

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Company Overview

Antigens & Antibodies

INFECTIOUS DISEASE EXPERTISE

Gastro •  H. Pylori

Tropical • Zika • Dengue 1, 2, 3, 4 • Chikungunya

ToRCH & Childhood • Toxo • Rubella • CMV

Viral Hepatitis • HAV • HBV • HCV • HDV • HEV

•  C. Difficile • Norovirus • Adenovirus • Rotavirus

• Malaria • Chagas

• HSV-1,2 • Rubeola • EBV • Mumps • Coxsackie • Rotavirus • RSV • Parvo B19 • VZV

• Cryptosporidium • Campylobacter •  E. Coli

• Leishmaniasis • Leptospirosis • Newcastle Disease • Yellow Fever • Nipah Virus • JEV

• Salmonella •  G. Lambia • Astrovirus

STD • HSV-1, 2 • HIV-1, 2 • HPV • Syphilis • Chlamydia • Neisseria

Respiratory • SARS-CoV-2

•  M. Pneumoniae •  C. Pneumoniae • Influenza A, B • Parainfluenza •  L. Pneumophilia • RSV •  M. Tuberculosis • Streptococcus • Staphylococcus • Adenovirus

IV

Cancer & Tumor Markers - Reagents for Assay Development

Cardiac • Troponin I, T • Myoglobin • BNP • NT-proBNP

Cancer • CA125 • CA15-3 • CA19-9 • CA72-4 • CA50 • CA242 • Cyfra 21-1 • CEA

Microbial Detection • Legionella • Salmonella • Cryptosporidium •  G. Lambia •  C. Jejuni •  E. Coli • Newcastle Disease • Canine Parvovirus • Rabies Virus • Serum Amyloid A (SAA) • Trichomonas foetus • Nipah • Transmissible Gastroenteritis Veterinary • ASFV • Avian Influenza • Borrelia •  Brucella abortus • Canine Distemper • Feline Immunodeficiency • Feline Leukemia • Foot-and-Mouth • Canine Heartworm • Infectious Bursal Disease • Marek Disease

Drug of Abuse • Amphetamine • Barbital • Benzodiazepine • Buprenorphine

• CRP • PCT • CK-MB • D-Dimer

• Cocaine • Cotinine • EDDP

• Fentanyl • Ketamine • K2 • MDMA (Ecstasy) • Methadone • Methamphetamine • Morphine • Norketamine • Opium • Oxycodone • PCP

• Cystatin-C • Galectin-3 • Vitamin D • Apo A, B, E • NSE • FABP • SAH • MPO • Fibrinogen • EGF

• Thyroglobulin • erbB-2/HER2 • AFP • EGFR

• HE4 • NSE • PMA • PAP • PSA

• PSMA • S-100 • PIVKA II • B2M

• Lp-PLA2 • PAPP-A

• Phenobarbital • Propoxyphene • THC

Hormones • LH, FSH, hCG, • hGH, AMH

Immunoglobulins/ Blockers • TRU Block ™ & IgM Diluent • Animal IgGs – Bovine, Chicken, Goat, Mouse, Rabbit, Sheep • Human IgA, IgG, IgM, IgE • Kappa Light chain • Lambda Light chain • Goat Anti-Human IgG, IgM, IgA • Goat Anti-Mouse IgG

Autoimmune • Jo-1 • PCNA

Allergens • Cat & Dog Allergen • Horse Allergen • Dust Mite • Alternaria alternate • Timothy Grass •  Platanus acerifolia • Mugwort • Cortisol • Estradiol • Insulin, C-peptide • Prolactin • Progesterone • PTH • PAPP-A • TSH, T3, T4, ACTH • Thyroglobulin

• pANCA • cANCA • Sm Ag • dsDNA • La(SSA) • Ro(SSA) • Histone • GMB • C1q • Scl-70 • SS-A • BS-Gly-1

•  B. Anthracis • Clostridium • Listeria

• Streptococcus • Staphylococcus

• Cathepsin G • Calprotectin

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Respiratory Infections & Diagnosis

Cancer is a leading cause of death worldwide. More than half of all cancer deaths each year are due to lung, stomach, liver, colorectal and female breast cancers. If recent trends in major cancers continue globally in the future, the burden of cancer will increase by 68% over the next 15 years. The high cancer mortality rates are primarily due to a delayed detection of the disease and differences in the policies on cancer screening between countries.

Early detection is the key focus of cancer diagnostics and an early diagnosis makes it possible to cure the disease completely and/or increase survival rates. However, the financial burden associated with the cost of managing and treating cancer is a growing concern. Non-invasive techniques such as serum immunoassays detecting specific tumor markers are highly sought after in order to minimize the costs associated with screening and monitoring the disease. They provide fast, cost-effective, and accurate cancer detection while providing a valuable aid to the clinician and increased comfort to the patient. Cancer biomarkers (also called tumor markers) are proteins produced either by the tumor itself or by the body in response to the presence of cancer. They can be broadly classified into four groups: (1) screening and early detection, (2) diagnostic confirmation, (3) prognosis and prediction of therapeutic response, and (4) monitoring disease and recurrence. Over the past decade, an improved understanding of carcinogenesis and tumor progression has revealed a large number of potential tumor markers. Some markers are associated with only one type of cancer, whereas others are associated with two or more cancer types. No “universal” tumor marker that can detect any type of cancer has been discovered.

FDA Approved Biomarkers for Cancer

Thyroid Cancer (Tg)

Breast Cancer (CA15-3/MUC-1, CA27-29, CEA, erb.2/HER2/new)

Pancreatic Cancer (CA19-9, CEA)

Liver Cancer (AFP)

Colon Cancer (CEA)

Ovarian Cancer (CA125, HE4)

Prostate Cancer (PSA)

VI | Cancer & Tumor Markers for Assay Development

Product Quickfind List

N NGAL/Lipocalin-2. ................................ 19 NSE....................................................... 19 O Osteopontin (OPN)............................... 19 P Pepsinogen I and Pepsinogen II ......... 20 PIVKA-II................................................. 20 Prolactin (PRL)...................................... 20 Prostate Secretory Protein (PSP)......... 20 PSA....................................................... 20 R Retinol Binding Protein 4 (RBP4)......... 21 S S-100. ................................................... 22 Serum Amyloid A (SAA)....................... 22 Sialyl Lewis A and Sialyl Lewis X......... 22 Superoxide Dismutase (SOD).............. 23 T Thymus and Activation Regulated Chemokine (TARC)............................... 23 Thyroid Peroxidase (TPO). ................... 23 Thyroglobulin (Tg)................................. 23 Tissue Transglutaminase (tTG)............. 23 Trypsin. ................................................. 24 TNF-alpha . ........................................... 24 U Urokinase (uPA).................................... 24 V Vitronectin. ........................................... 24

A Alpha 1 Antitrypsin (A1AT)..................... 4 Alpha 2 Macroglobulin (A2M)................ 4 Alpha Fetoprotein (AFP)......................... 4 Amylase.................................................. 5 Apolipoprotein CI (Apo CI). .................... 5 Apolipoprotein E (Apo E)........................ 5 B Beta 2 Microglobulin (B2M)................... 6 C Cadherin-E.............................................. 6 Calcitonin................................................ 6 Calprotectin L1....................................... 6 CA125..................................................... 7 CA15-3/MUC1)....................................... 7 CA19-9.................................................... 8 CA50....................................................... 8 CA72-4 (TAG-72). ................................... 8 CA242..................................................... 8 CEA......................................................... 9 Catalase.................................................. 9 CD1d....................................................... 9 CD3......................................................... 9 CD8....................................................... 10 CD13 (Aminopeptidase N)................... 10 CD15..................................................... 10 CD24..................................................... 10 CD28..................................................... 10 CD30..................................................... 10 CD37..................................................... 11 CD42 .................................................... 11 CD49d................................................... 11 CD57 .................................................... 11 CD59..................................................... 11 CD66b................................................... 11 CD90..................................................... 12 CD105 (Endoglin)................................. 12 CD147................................................... 12 CD177................................................... 12 CD195 (CCR5)...................................... 12 Centromere Protein B (CENPB)........... 13 c-Myc.................................................... 13 Collagen Type VI................................... 13 Cyfra 21-1............................................. 13

D Defensin-beta....................................... 13 Desmin................................................. 14 Disialoganglioside GD2........................ 14 E Elastase................................................ 14 EGFR. ................................................... 14 erbB-2, HER2/neu................................ 15 EpCAM ................................................ 15 F Factor H (Beta 1H). .............................. 15 Factor VIII (FVIII)................................... 15 G GAPDH ................................................ 15 H Heat Shock Proteins. ........................... 16 Hemoglobin.......................................... 16 HE4....................................................... 16 I IGF-I ..................................................... 16 IGFBP-3................................................ 17 Integrin alpha M (CD11b/MAC-1)........ 17 Interferon gamma (IFN-gamma).......... 17 IL-1a and IL-1R .................................... 17 L Lactate Dehydrogenase (LDH)............ 17 Lamin.................................................... 18 Leptin.................................................... 18 Lysozyme............................................. 18 M Microtubule Associated Protein 2 (MAP-2)................................................. 18 Mast Cell Tryptase (MCT).................... 18 Monocyte Chemotactic Protein 1 (MCP-1)................................. 19

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Leading Products

Antibodies & Matched Pairs

Alpha Fetoprotein (AFP) M86304M

Epidermal Growth Factor Receptor 2 (ERB2, HER2/NEU) M01296M

MAb (Capture) , ELISA MAb (Detection) , ELISA

M86641M

MAb, ELISA, reacts with peptide ILDV4 (dephosphorylated) MAb, ELISA, reacts with peptide ILDV4 (phosphorylated) MAb, ELISA, reacts with peptide ILDV2 (dephosphorylated) MAb, ELISA, reacts with peptide ILDV2 (phosphorylated)

* Not cross reactive with human albumin. MAM01-210 MAb (Capture) , ELISA MAM01-301 MAb (Detection) , ELISA

M01297M

M01298M

Beta 2 Microglobulin (B2M) MCP17-301 MAb, ELISA & RIA * Reacts with soluble B2M and B2M associated with cell-surface MHC Class I molecules and other membrane antigens. CA125 M86306M MAb Group A (Capture) , ELISA & WB M86924M MAb Group B (Detection) , ELISA & WB M86306M MAb Group A (Capture) , ELISA & WB M86429M MAb Group B (Detection) , ELISA & WB * Both pairs detect OC125 (Group A) and M11 (Group B). CA19-9 M66107M MAb (Capture) , ELISA M66106M MAb (Detection) , ELISA M66108M MAb (Alternate Detection) , ELISA M66106M MAb (Capture/Detection) , ELISA M66108M MAb (Capture/Detection) , ELISA * Abs can be used as capture or detection in a sandwich assay. CA72-4 M01341M MAb (Capture) , ELISA M01342M MAb (Alternate Capture) , ELISA M01340M MAb (Detection) , ELISA CEA

M01299M

HE4 M01323M M01320M M01323M M01321M

MAb (Capture) , ELISA MAb (Detection) , ELISA

MAb (Capture) , ELISA

MAb (Detection) , ELISA Human Hemoglobin (Fecal Occult Blood) H01348M MAb (Capture) , ELISA H01349M MAb (Detection) , ELISA H01416M MAb (Capture) , ELISA H01369M MAb (Detection) , ELISA H01409M MAb (Capture) , LF & Turbidimetry H01410M MAb (Detection) , LF & Turbidimetry Neuron Specific Enolase (NSE) M86101M MAb (Capture/Detection) , ELISA M86520M MAb (Capture/Detection) , ELISA * Abs can be used as capture or detection in a sandwich assay. Pepsinogen I K01402M MAb (Capture) , ELISA & LF K01403M MAb (Detection) , ELISA & LF K01406M MAb (Capture) , ELISA & LF K01407M MAb (Detection) , ELISA & LF Pepsinogen II K01404M MAb (Capture) , ELISA & LF K01405M MAb (Detection) , ELISA & LF

MAM02-008 MAb (Capture/Detection) , ELISA MAM02-009 MAb (Capture/Detection) , ELISA * Abs can be used as capture or detection in a sandwich assay.

MAM02-009 MAb (Capture) , ELISA MAM02-881 MAb (Detection) , ELISA M01250M

MAb (Capture) , ELISA & IHC MAb (Detection) , ELISA & IHC

M01246M

PIVKA-II M01344M M01343M

* Specific for CEA epitope specificity group I.

MAb (Capture) , ELISA

Cyfra 21-1 (Cytokeratin 19) M01300M MAb, ELISA & WB M01326M MAb, ELISA

MAb (Detection) , ELISA Prostate Specific Antigen (PSA) Free M92986M MAb (Capture) , ELISA M92396M MAb (Detection) , ELISA * Not cross reactive to Albumin, AFP, CEA, PAP, CA125, CA19-9 or CA15-3. M86506M MAb (Capture/Detection) , ELISA & LF M86806M MAb (Capture/Detection) , ELISA & LF

2 | Cancer & Tumor Markers for Assay Development Cancer & Tumor Markers - Reagents for Assay Development 2

Prostate Specific Antigen (PSA) Total M66276M MAb (Capture) , ELISA & LF M86506M MAb (Detection) , ELISA & LF * Specific for epitope 5 and not cross reactive with human kallikrein 2. M01236M MAb (Capture) , ELISA & LF M86506M MAb (Detection) , ELISA & LF S-100 Beta Q86006M MAb (Capture) , ELISA Q86610M MAb (Detection) , ELISA

Q86003M Q86610M

MAb (Capture) , ELISA

MAb (Detection) , ELISA * Each capture is specific for alpha-beta and each detection for alpha-beta and beta-beta. Thyroglobulin E01326M MAb (Capture) , ELISA E01325M MAb (Detection) , ELISA * Does not interfere with anti-thyroglobulin auto-antibodies.

Human Antigens (for use as standards, controls & calibrators)

Alpha Fetoprotein (AFP) A32260H

Neuron Specific Enolase (NSE) A86803H

Produced in cell culture, derived from a liver tumor cell and contains approximately 70% of the AFP-L3 isoform, ≥ 95% pure (SDS-PAGE & WB)

From human brain, > 95% pure (SDS-PAGE)

Pepsinogen II A01691H

Purified from human stomach, lyophilized, ≥ 90% pure (SDS-PAGE)

Beta 2 Microglobulin (B2M) A01412H

Pepsinogen II A01420H

From human urine, ≥ 98% pure (SDS-PAGE)

From human gastric mucosa, > 90% pure (SDS-PAGE) Purified from human stomach, lyophilized, ≥ 90% pure (SDS-PAGE) PSA, from human seminal fluid, lyophilized, > 95% pure (SDS-PAGE) PSA/ACT Complex, from human seminal fluid and plasma, > 95% pure (SDS-PAGE) PSA, From human seminal fluid, lyophilized, > 98% pure (SDS-PAGE) From human brain tissue, contains both beta-beta and alpha-beta isoforms, > 95% pure From human brain tissue, contains only beta-beta homodimer, > 95% pure (SDS-PAGE)

CA15-3 A32231H CA125 A32180H CA19-9 A86199H A01458H CA72-4 A01723H CA50 A01264H CEA A32030H A38151H

Produced in cell culture, low cross reactivity

A01692H

Prostate Specific Antigen (PSA) A01368H

Produced in cell culture, low cross reactivity

From native human metastatic liver carcinoma Produced in cell culture, provided as cell culture concentrate

A31029H

A86878H

Produced in cell culture, low cross reactivity

S-100 Beta A86809H

Produced in cell culture, provided as cell culture concentrate

A86289H

Thyroglobulin H6T08-747

Produced in cell culture, > 50% pure (SDS-PAGE)

From native human liver metastases, > 95% pure (SDS-PAGE)

From human thyroid tissue, > 98% pure (SDS-PSGE) From human thyroid tissue, > 90% pure (SDS-PAGE)

A86852H

Cyfra 21-1 A32340H

Produced in cell culture, low cross reactivity

Human Hemoglobin (Fecal Occult Blood) A38192H From human erythrocytes, > 96% pure (SDS-PAGE)

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Product list

Alpha 1 Antitrypsin (A1AT)

Abbreviations 6-His – Polyhistidine-tag Aff.Pur. – Affinity Purified, analyte-specific column Ag – Antigen Alk.Phos. – Alkaline Phosphatase conjugated product CLIA – Chemiluminescence Immunoassay CVD – Cardiovascular Disease DB – Dot Blot DFA – Direct Immunofluorescence Assay FC – Flow Cytometry FITC – Fluorescein conjugated product GST – Glutathione S-transferase HRP – Horseradish peroxidase conjugated product IB – Immunoblot

A1AT is a secretory glycoprotein mainly produced in the liver and monocytes. It is the most abundant serine protease inhibitor in human plasma. Several cancers are associated with A1AT deficiency including primary liver carcinoma, lung cancer, bladder cancer and malignant hepatoma. Monoclonals • Does not cross-react with alpha 1 antichymotrypsin H45200M

Alpha 2 Macroglobulin (A2M)

A2M functions as a universal protease inhibitor in serum and is capable of binding various cytokines and growth factors. Malignant tumors are able to synthesize and release proteins into the circulation, including A2M that protects the tumor against immune system attacks. A common variant of A2M has also been suggested to lead to an increased risk of Alzheimer’s disease. Polyclonals CATALOG SOURCE FORMAT APPLICATION L04330G Goat Monospecific IEP Antigens A50114H • Native antigen from human plasma • > 95% pure (SDS-PAGE), lyophilized

ICC – Immunocytochemistry IEP – Immunoelectrophoresis IFA – Immunofluorescence Assay

IgG – Immunoglobin G IgM – Immunoglobin M IHC – Immunohistochemistry IP – Immunoprecipitation LF – Lateral Flow Lysate – Cells which have been lysed MAb – Monoclonal antibody Monospecific – Single band when tested by immunoelectrophoresis Neat – Whole, unpurified, undiluted antisera Neph – Product has been quality controlled by Nephelometry PAb – Polyclonal antibody Purified/IgG – Refer to the Certificate of Analysis regarding the extent of purification and the purification process used. RIA – Radioimmunoassay RID – Radial Immunodiffusion SDS-PAGE – Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis TIA – Product has been quality controlled by Turbidimetry WB – Western blot

Alpha Fetoprotein (AFP)

AFP is a tumor marker used to help detect and diagnose cancers of the liver, testicles, and ovaries. AFP can be fractionated by affinity electrophoresis into 3 glycoforms: L1, L2, and L3. AFP-L3 is specific to malignant tumors. An AFP-L3 test is used to help evaluate the risk of developing hepatocellular carcinoma, especially in those with chronic liver disease, and also to evaluate response of hepatocellular carcinoma to treatment. Monoclonals • Does not cross-react with human serum albumin • Suitable for ELISA • MAbs produced in vivo (unless otherwise noted)

M01254M M01255M M86304B M86641M M86501M

* Also works in LF assays

* Biotin conjugated

* Reacts with AFP Receptor, suited to blocking AFP/ AFP-binding

4 | Cancer & Tumor Markers for Assay Development Cancer & Tumor Markers - Reagents for Assay Development 4

Alpha Fetoprotein (AFP) continued

Apolipoprotein CI (Apo CI)

Antibody Pairs • Suitable for ELISA • MAbs produced in vivo (unless otherwise noted) CAPTURE DETECTION H45610M H45301M

Apo CI is the smallest member of the apolipoprotein family and is mainly distributed on the surface of very low density lipoprotein (VLDL) chylomicrons and high density lipoprotein. Apo CI is a potential serum marker for colorectal cancer, prostate cancer, breast cancer, lung cancer, thyroid carcinoma, malignant pleural mesothelioma, gastric cancer, pancreatic cancer and Wilms’ tumor. Polyclonals CATALOG SOURCE FORMAT APPLICATION K74110R Rabbit Aff.Pur. ELISA,IB

* Does not react with human albumin, ferritin, hCG or PSA

MAM01-210 MAM01-301 M86304M M86641M

* Does not react with human albumin

Polyclonals CATALOG

SOURCE FORMAT APPLICATION

K92204R Rabbit

Purified

ELISA

Apolipoprotein E (Apo E)

Antigens A01406H

Apo E is a class of apolipoproteins found in the chylomicron and intermediate-density lipoprotein. It has been linked to cardiovascular disease, Alzheimer’s disease, dementia, atherosclerosis, multiple sclerosis, peripheral artery disease, diabetes, stroke, and most recently, cancer, including breast and ovarian cancer. Monoclonals • Reacts to the E2, E3 and E4 isoforms of apolipoprotein E • Produced in vivo • Suitable for ELISA, IHC, IP and WB H06579M

• Native antigen from human cord serum • Suitable for use in ELISA and WB • > 99% pure (SDS-PAGE) • Native antigen from human cord serum • Suitable for use in ELISA and WB • > 99% pure (SDS-PAGE), lyophilized • Native antigen from human hepatocellular carcinoma cell line • Contains approximately 70% of the AFP-L3 isoform • 95% pure (SDS-PAGE) • Suitable for use in ELISA and WB

A01407H

A32260H

• Reacts with VLDL of human plasma • Suitable for use in ELISA and IHC • Produced in vivo , lyophilized H61529M Polyclonals CATALOG

Amylase Amylase is produced by the exocrine pancreas and the salivary glands to aid in the digestion of starch. Amylase enzyme levels may be increased in some pancreas, salivary, prostate, lung and ovarian tumors. In general, the blood amylase test is used to help diagnose and monitor acute pancreatitis. Antigens A38120H • Native alpha amylase from human pancreas • Specific activity of 450 Units/mg protein (lot dependent) • Purified and lyophilized

SOURCE FORMAT APPLICATION

G5C27-766 Goat K34002G Goat K74190G Goat K74180B Goat

Aff.Pur.

N/A

HRP

ELISA,WB ELISA,WB ELISA,WB

Aff.Pur.

Biotin

Antigens A50120H

• Native antigen from human plasma (VLDL) • > 95% pure (SDS-PAGE)

A38211H

• Native alpha amylase from human saliva • Specific activity of 620 Units/mg protein (lot dependent) • > 90% pure (SDS-PAGE), lyophilized • Native alpha amylase from pig pancreas • Specific activity of 640 Units/mg protein (lot dependent) • Purified and lyophilized

A01389P

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Product list | Continued

Monoclonals • Recognizes Cadherin-E expressed on non-neuronal epithelial cells

Beta 2 Microglobulin (B2M) B2M is a protein involved with MHC class I molecules which is found on the surface of almost all nucleated cells. Elevated levels of B2M are noted in lymphoproliferative disorders, neoplasms (malignant and benign), inflammatory disease, and autoimmune diseases such as systemic lupus erythematosus and Sjögren’s disease. For cancer, it is not diagnostic for a specific type, but it has been associated with the amount of cancer present (tumor burden) and can be used as a prognostic tumor marker for some blood cell cancers. Monoclonals • Recognizes the HLA-B2M complex, free or associated with the membrane • Suitable for use in FC, IHC and IFA • Lyophilized H42114M • Reacts with soluble forms of B2M and B2M associated with cell-surface MHC Class I molecules and other membrane antigens • Suitable for use in ELISA, WB, FC, IP, and RIA MCP17-301 Polyclonals CATALOG SOURCE FORMAT APPLICATION K01372G Goat Aff.Pur. N/A Antigens A01447H • Native antigen from human urine

• Suitable for use in IHC and IP • Produced in vivo , lyophilized P91176M

Calcitonin Calcitonin is polypeptide hormone that is produced by the C-cells of the thyroid gland and it acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH). Calcitonin assay is used to identify patients with nodular thyroid diseases and to diagnose medullary thyroid cancer. Antibody Pairs

• Suitable for use in CLIA, ELISA and RIA • Recognizes Native Human Calcitonin CAPTURE DETECTION E01357M E01356M

Calprotectin L1 Calprotectin L1 is a neutrophil-derived protein that can be quantified in the feces and has become an established marker of whole gut inflammation. Fecal calprotectin levels are associated with lifestyle risk factors for colorectal cancer. Antibody Pairs

• Suitable for use in ELISA with stool samples • MAbs produced in cell culture, lyophilized CAPTURE DETECTION K01373M K01376M

• Suitable for use in ELISA • 98% Purity (SDS-PAGE)

A01410H

• Native antigen from human urine • > 98% Purity (SDS-PAGE), lyophilized • Native antigen from human urine • 98% Purity (SDS-PAGE) • Recombinant (E.coli) • 95% Pure (HPLC), lyophilized

• MAb to Calprotectin • Produced in cell culture • Suitable for ELISA and lateral flow CAPTURE DETECTION 9591 9591 Monoclonals • Suitable for use in ELISA • Produced in cell culture, lyophilized

A01412H

A01468H

Cadherin-E Cadherin-E is a calcium dependent cell adhesion molecule expressed predominately in epithelial tissues. It plays an important role in the growth and development of cells via the mechanisms of tissue architecture and the maintenance of tissue integrity. It is an important determinant of tumor progression, serving as a suppressor of invasion and metastasis (loss of Cadherin-E function promotes tumor progression).

K01374M K01375M

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6 | Cancer & Tumor Markers for Assay Development

Cancer & Tumor Markers - Reagents for Assay Development

Cancer Antigen 125 (CA125) A protein in humans that is encoded by the MUC16 gene and found on the surface of many ovarian cancer cells. Monitoring CA125 blood serum levels is also useful for determining how ovarian cancer is responding to treatment and for predicting a patient’s prognosis after treatment. CA125 can also be found in other cancers and in small amounts in normal tissue. Antibody Pairs

Cancer Antigen 15-3 (CA15-3 or MUC1) CA15-3 is a tumor marker which corresponds to an immuno- dominant epitope in the extracellular portion of the membrane bound mucin MUC1. It is used to monitor a patient’s response to breast cancer treatment and disease recurrence. CA15-3 and the associated CA27.29 are different epitopes on the same gene product. Antibody Pairs • Binds to an epitope within the VNTR tandem repeat peptide region of MUC1 • Suitable for use in ELISA and IHC • MAbs produced in in vivo CAPTURE DETECTION SPECIFIC FOR CA15-3 M86240M M01289M * Underglycosylated M86240M M86240M * Unglycosylated Antigens A32231H • Low cross-reactivity ideal for multi-analyte panels • Suitable for use as a calibrator or control • Suitable for use in CLIA • Cell culture derived protein from human BTA cell line A86153H • Native antigen from human milk

• Detects both Group A and Group B • Suitable for use in ELISA and WB • MAbs produced in in vivo CAPTURE DETECTION M86306M M86924M M86306M M86429M Monoclonals • Suitable for use in ELISA and WB • MAbs produced in vivo M86306B

* Specific to Group A, biotin conjugated * Specific to Group B, biotin conjugated

M86429B

Antigens A01693H

• Ovarian Cancer, Calibrator Grade • Low cross-reactivity

• Suitable for use as a calibrator or as an immunogen for antibody development • Suitable for use in CLIA and WB • Cell culture derived protein from human BTA cell line • Native antigen from human fluids • High purity (relative Purity Ratio: > 20,000 Units/mL/OD280nm) • Suitable for use in ELISA and WB

A32180H

• Suitable for use as a calibrator for single or multiple analyte controls • Low cross-reactivity ideal for multi-analyte panels • Cell culture derived protein

A32000H

A97180H

• Cell culture derived protein from ovarian carcinoma cell line • Suitable for use in WB and RIA • Cell culture derived protein from human adenocarcinoma cell line • Suitable for use as a calibrator • Cell culture derived protein from human adenocarcinoma cell line • Suitable for use as a calibrator • > 50% pure (SDS-PAGE) • Partially pure antigen from human fluids • Low cross-reactivity • Suitable for use in ELISA and Electrochemiluminescence assay as a calibrator or control

A01436H

A86125H

Please note that cell culture derived antigens offer several advantages over the native fluid versions, including greater availability of the product.

A86928H

A01690H

Please note that cell culture derived antigens offer several advantages over the native fluid versions, including greater availability of the product.

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Product list | Continued

Cancer Antigen 19-9 (CA19-9)

Cancer Antigen CA72-4 (TAG-72)

Also called sialylated Lewis (a) antigen, CA19-9 is a tumor marker used primarily in the management of pancreatic cancer. CA19-9 is also elevated in many types of gastrointestinal cancer, such as colorectal cancer, esophageal cancer and hepatocellular carcinoma. Apart from cancer, elevated levels may also occur in pancreatitis, cirrhosis, and diseases of the bile ducts. Monoclonals • Suitable for IHC • Produced in in vivo M01237M Antibody Pairs • Suitable for use in ELISA • MAbs produced in vivo (unless otherwise noted) CAPTURE DETECTION

CA72-4 is a mucinous glycoprotein used as a tumor marker for gastric carcinoma and ovarian cancer (clinical studies demonstrated diagnostic specificity of more than 95%). Elevated CA72-4 levels in serum and plasma have also been reported in other cancers including carcinomas of the pancreas, stomach, gallbladder, colon, cervix and endometrium. There is a good correlation between serologic CA72-4 levels and tumor stage and size. It has been used as an independent marker for the therapeutic monitoring and follow-up care of ovarian cancer patients, in particular in CA125 negative patients. Antibody Pairs

• Suitable for use in ELISA • MAbs produced in vivo CAPTURE DETECTION M01341M M01340M M01342M M01340M

M66106M M66108M M66107M M66106M M66107M M66108M M66108M M66106M Antigens A32502H

* Pair does not cross-react CA72-4, PSA, CA125, CA242, and CEA

Cancer Antigen 242 (CA242)

CA242 is related to the sialylated Lewis (a) blood group antigen (Ag-CA19-9) but it is chemically and immunologically distinct. It is used as a tumor marker for the early diagnosis of pancreatic cancer. It has been demonstrated that the CA242 and CA19-9 epitopes are co-expressed on the same mucins, however the detailed structure of the CA242 epitope has not been established. CA242 is suggested to be more specific than CA19-9 in the diagnosis of pancreatic cancer and overall there are differences in the relative expression of CA19-9 and CA242 between benign and malignant diseases and between carcinomas of various organs. Antigens A01267H • Cell culture derived protein • Suitable for use as a calibrator Please note that cell culture derived antigens offer several advantages over the native fluid versions, including greater availability of the product.

• Cell culture derived protein from human adenocarcinoma cell line • Suitable for use in CLIA • Native antigen from metastatic liver carcinoma • Suitable for use as a calibrator and an immunogen for antibody development • Cell culture derived protein • Concentrated (~76,000 U/mL), lot dependent

A86199H

A01458H

Please note that cell culture derived antigens offer several advantages over the native fluid versions, including greater availability of the product.

Cancer Antigen 50 (CA50)

CA50 cancer antigen is a glycolipid and elevated levels of CA50 are found in liver cirrhosis and diseases of the pancreas. CA50 is most prevalent in gastrointestinal cancers, but can also be associated with cancer outside the digestive tract. Antigens A01264H • Cell culture derived protein Please note that cell culture derived antigens offer several advantages over the native fluid versions, including greater availability of the product.

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8 | Cancer & Tumor Markers for Assay Development

Cancer & Tumor Markers - Reagents for Assay Development

Carcinoembryonic Antigen (CEA) CEA is a type of glycoprotein molecule that is produced by cells of the gastrointestinal tract during embryonic development and CEA is generally present in low levels in the blood. Elevated levels of CEA are detectable in certain types of cancer and to-date CEA is the most widely used tumor marker for assessing prognosis, detecting recurrence and monitoring treatment in people with colorectal cancer. High levels of CEA are also detectable in cancers of the pancreas, stomach, breast, lung, medullary carcinoma of the thyroid, and ovarian cancer. Monoclonals • Suitable for use in enzyme conjugation, radio-labeling or solid phase immobilization • Produced in vivo H45655M • Suitable for use in FC • Specific for epitope group V M01329M Antibody Pairs

Catalase Catalase is an important enzyme that protects cells from oxidative damage by reactive oxygen species. Catalase is frequently down-regulated in tumors although the underlying mechanism remains unclear. It has been recommended for use as a biomarker for the diagnosis, prognosis, and treatment of breast cancer.

Antigen A50136H

• Native antigen from human erythrocyte • 95% pure (SDS-PAGE) • > 50,000 units/mg protein (lot dependent)

CD1d CD1d encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. Studies have shown that breast cancer cells, through downregulation of CD1d and subsequent evasion of NKT-mediated antitumor immunity, gain increased potential for metastatic tumor progression. Monoclonals • Suitable for use in IHC and IP • Produced in cell culture P01242M CD3 CD3 consists of a protein complex with four chains and it is required for T-cell activation. CD3 expression can be detected at all stages of T-cell development. Studies have shown that patients with an unresponsive CD3 receptor have a significantly higher incidence of recurrent head and neck squamous cell carcinoma. CD3 is also under investigation as a target for immunosuppressant therapies for type 1 diabetes and other autoimmune diseases. Monoclonals • Produced in vivo MAL66-801

• Suitable for use in ELISA • MAbs produced in vivo CAPTURE DETECTION MAM02-008 MAM02-009 MAM02-009 MAM02-007 MAM02-009 MAM02-008 MAM02-009 MAM02-881 M01250M M01246M

* Also works in IHC

Polyclonals CATALOG SOURCE FORMAT

APPLICATION

K10290G Goat

Neat

ELISA

Antigens A01442H

• Native antigen from human fluids • Suitable for use in ELISA • 98% (SDS PAGE) • Native antigen from human fluids • Suitable for use in ELISA • Purified antigen from cell culture • > 50% pure (SDS-PAGE) • Purified antigen from human colon adenocarcinoma cell line •  95% pure (SDS-PAGE)

A86808H

A32030H

A38151H

Please note that cell culture derived antigens offer several advantages over the native fluid versions, including greater availability of the product.

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CD8 CD8 is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor. CD8-positive T-cells represent a major arm of the cell-mediated anti-tumor response and a promising target for developing T-cell-based immunotherapies against lung cancer. The chronic presence of lung tumors induces dysfunctions in CD8-positive T-cells and sensitizes them to activation-induced cell death, which may be associated with poor clinical responses. Monoclonals • Produced in vivo MAL08-804

CD24 CD24, a heat stable antigen, is a surface marker expressed in many tumor types. It has been identified as a marker of cancer stem cells (CSCs) and several studies suggest that CD24-positive tumors are related to a poor prognosis and for several cancer types. Monoclonals • Recognizes B-cells from pre-B to mature-B stage

• Suitable for use in FC and IHC • Produced in vivo , lyophilized P42118M

CD28 CD28 is one of the proteins expressed on T-cells that provides co-stimulatory signals required for T-cell activation and survival. It is also the receptor for CD80 and CD86 proteins. Studies have shown that it is a marker associated with tumoral expansion in multiple myeloma. Monoclonals • Induces T-cell proliferation in co-stimulation with CD2 monoclonal antibodies • Suitable for use in FC • Produced in vivo P42235M CD30 CD30 is a cell membrane protein of the tumor necrosis factor receptor family and a tumor marker. CD30 is associated with anaplastic large cell lymphoma. It is expressed in embryonal carcinoma and on classical Hodgkin Lymphoma Reed-Sternberg cells. In 2011, the FDA approved an agonistic anti-CD30 drug conjugate, Brentuximab vedotin, for the treatment for CD30-positive lymphomas Monoclonals • Suitable for use in FC, IHC and IFA • Produced in vivo , lyophilized P42705M

CD13 (Aminopeptidase N)

CD13 is a Zn 2+ dependent membrane-bound ectopeptidase that preferentially degrades proteins and peptides with a N-terminal neutral amino acid. It has been associated with the growth of different human cancers and is suggested to be a suitable target for anti-cancerous therapy. Monoclonals • Suitable for use in FC and IHC • Produced in cell culture, biotin conjugated P01150B

CD15

CD15 is a complex cluster of cell surface glycoproteins and glycolipids having a common terminal pentasaccaharide known as the Lewisx (Lex) antigen. In haematopathology, CD15 is important for the diagnosis of classical Hodgkin’s disease and the characterization of acute leukemia. CD15 may be used for histopathological grading of gliomas and differentiating between malignant gliomas and non-neoplastic glial cells. Hepatocellular, gastric, and colonic carcinoma and thyroid medullary carcinoma also appear to have worse prognosis if positive for CD15. Monoclonals • Suitable for use in FC, IHC and IFA • Produced in cell culture P01158B

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10 | Cancer & Tumor Markers for Assay Development r

r rk rs - Reagents for Assay Development

CD37 CD37 antigen is a transmembrane protein of the tetraspanin superfamily that is highly expressed on B-cells during the pre-B to peripheral mature B-cells. In normal tissues, CD37 expression is restricted to lymphoid tissues. However, CD37 is highly expressed on malignant B-cells in non-Hodgkin lymphoma and chronic lymphocytic leukemia which suggests that CD37 could be a promising therapeutic target for B-cell malignancies. Monoclonals • Suitable for use in ELISA, IHC and IP • Produced in vivo K8A069M CD42 CD42 is a cell-surface glycoprotein involved in cell–cell interactions, cell adhesion and migration. It participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Monoclonals

CD57 CD57 is a glycoprotein with cell adhesion functions normally expressed on NK-cells. It serves as a marker of NK cells and neuroendocrine tumors and helps distinguish high grade prostatic adenocarcinoma (CD57-positive) from high grade urothelial carcinoma (CD57-negative). Monoclonals • Suitable for use in WB, IHC and FC • Produced in cell culture P01287M CD59 CD59 is a glycoprotein expressed on all human peripheral blood leukocytes, erythrocytes, and several human cell lines. It is a potent inhibitor of the complement membrane attack complex (MAC) action. Its overexpression has been observed in many types of solid cancers, such as pancreatic cancer and lung cancer. Monoclonals • Reacts with a well-defined epitope (W40, R-53) on CD59 • Suitable for use in FC and IP • Produced cell culture MAL59-043 CD66b CD66b, also known as carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8), is expressed mainly on granulocytes such as a GPI anchored molecule and its main functions are cell adhesion, cell migration, and pathogen binding. Under normal conditions, neutrophils have minimal expression of CD66b, however, in chronic myeloid leukemia its expression is upregulated. Monoclonals

• Specific for CD42b • Suitable for use in FC • Produced in vivo , lyophilized N42409M

CD49d CD49d is an integrin alpha subunit composed of a β 4 (CD49d) and a β 1 (CD29) chain and serves as a receptor for fibronectin and VCAM-1. It is normally expressed on monocytes, T-cells, and eosinophils and mainly functions as a cell adhesion and signaling molecule. In cancer, it is an independent prognostic marker for disease progression in patients with chronic lymphocytic leukemia. Monoclonals

• Suitable for use in FC and IFA • Produced in vivo , FITC labelled P42531F

• Suitable for use in FC and IFA • Produced in vivo , lyophilized P42764M

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CD71 CD71, the transferrin receptor, is involved in the cellular uptake of iron and is expressed on cells with high proliferation. Data suggests that it might be implicated in promoting the growth of endocrine resistance in breast cancer and may serve as a prognostic marker of poor outcome and resistance to tamoxifen. Monoclonals • Recognizes soluble and bound transferrin receptor • Suitable for use in ELISA and WB • Produced cell culture H01372M • Suitable for use in ELISA and WB • Produced in vivo H86602M CD90 CD90 is a cell surface glycoprotein involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. It is widely used as a marker for hematopoietic stem cells and has been identified as a valuable marker to differentiate epithelioid mesothelioma from lung carcinoma. It may also function as a tumor suppressor in nasopharyngeal carcinoma. Monoclonals • Suitable for use in WB, IFA, FC, and IP • Produced in cell culture P01283M CD105 (Endoglin) CD105 is an accessory protein of the transforming growth factor-beta receptor system and is expressed on vascular endothelial cells. Studies have identified CD105 expression in several solid tumor types, with the level of expression correlating to various clinicopathologic factors including decreased survival and presence of metastases. It is an independent predictive marker for death risk and unflavorable prognosis in patients with renal cell carcinoma. Monoclonals • Suitable for use in WB, IP and FC • Produced in vivo MAL105-226

CD147 CD147, an extracellular matrix metalloproteinase inducer, is correlated with tumor aggressiveness in various human malignanciesis including ovarian and gastric cancers. Its expression is highly associated with cancer invasion and metastasis and it has the potential to serve as a prognostic biomarker (e.g. poor outcome). Monoclonals • Recognizes an epitope in the N-terminal Ig domain (D1) • Suitable for use in FC • Produced in vivo P87535M * Also works in WB and IP

CD177

CD177 is an important membrane glycoprotein on neutrophils and serves as a marker for myeloproliferative diseases. Loss of CD177 expression is linked to higher metastasis incidence and shorter survival in breast cancer patients. Monoclonals • Suitable for use in WB, FC and IP • Produced in vivo MAL177-166

CD195 (CCR5)

CD195 is a protein on the surface of white blood cells that is involved in the immune system and it acts as a receptor for chemokines, specifically CCL3 (MIP1 α ), CCL4 (MIP1 β ) and CCL5 (RANTES). It is also used by HIV (along with CXCR4) to enter target cells. CD195 has been implicated to play a role in the metastasis of breast cancer and colorectal cancer. Monoclonals

• Suitable for use in FC • Produced cell culture P01240M

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12 | Cancer & Tumor Markers for Assay Development

ancer Tu or arkers - Reagents for Assay Development

Centromere Protein B (CENPB) CENPB is a highly conserved DNA protein that facilitates centromere formation. It is used as a serologic marker for autoimmune diseases, specifically sclerosis and other rheumatic conditions. It is also a potential biomarker of small-cell lung cancer and a prognostic marker for breast cancer (indicating prolonged survival). Antigens A01375H • Recombinant ( Sf9 Insect Cells) • Suitable for use in ELISA and WB • > 95% pure (SDS-PAGE)

Cyfra 21-1, Cytokeratin 19 Fragment Cyfra 21-1 is a sensitive and specific tumor marker of lung cancer, especially of the squamous cell subtype. An assay for Cyfra 21-1 was first approved by the FDA in 2011 to monitor disease progression and treatment of lung cancer patients. It is also reported to be a potential biomarker for ovarian cancer. Monoclonals • Suitable for use in ELISA • Produced in vivo

M01300M Antigens A32340H

R01646

• Recombinant ( Sf9 Insect Cells) • Suitable for use in ELISA and WB • 90% pure (SDS-PAGE)

• Native antigen from MCF-7 Cell Supernatant • Calibrator Grade with low cross-reactivity • Suitable for use in CLIA

c-Myc c-Myc a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. A mutated version causing consituative expression of c-Myc is found in many cancers, including Burkitt lymphoma the cervical, ovarian, colon, breast, lung and stomach cancers. Monoclonals • Produced in vivo MAB07-510 * Suitable for use in WB and IHC Collagen Type VI Collagen Type VI is a widely distributed extracellular matrix macromolecule that plays a crucial role in tissue development and is highly expressed in cancers. Studies show that it promotes chemotherapy resistance, and specifically in breast cancer it regulates cancer progression and metastasis. Antigens A33129H • Native antigen from human placental villi • Suitable for use as a standard, or for antibody production • > 90% pure (SDS-PAGE)

Defensin-beta Human defensins are small cationic peptides produced by neutrophils and epithelial cells and they form two genetically distinct alpha and beta subfamilies. Defensins are involved in various aspects of the innate and acquired immune responses and recently, single nucleotide polymorphisms of beta-defensins have been correlated with increased susceptibility to cancer. Specifically, in oral cancer beta-defensins are down-regulated indicating that it may play a role in tumor suppression. Monoclonals • Suitable for use in ELISA • Produced in cell culture, lyophilized EPITOPE BINDING P24141M a.a. 1-36, Defensin-beta 1 * Also works in WB P24011M a.a. 4-41, Defensin-beta 2 Antigens A24100H • Synthetic peptide representing a.a. 4-41 (Defensin-beta 2) • > 95% pure (HPLC), lyophilized A24601H • Synthetic peptide representing a.a. 3-39 (Defensin-beta 4) • > 95% pure (HPLC), lyophilized

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Desmin Desmin is a type III intermediate filament in smooth muscle tissue and has a wide variety of functions. Several studies have shown that desmin is a highly sensitive marker for endothelial cell differentiation and tumor invasiveness in several types of cancers, including colon cancer, gastrointestinal stromal tumors, and embryonal sarcoma. Monoclonals • Produced in vivo MAM26-014

Epidermal Growth Factor Receptor (EGFR) EGF is a growth factor that stimulates cell growth, proliferation, and differentiation by binding to its receptor EGFR. Dysregulation of EGF and mutations that lead to EGFR overexpression have been associated with a number of cancers, including lung, breast and anal cancers as well as glioblastoma multiforme. Many therapeutic approaches are aimed at the EGFR such as cetuximab and panitumumab. Monoclonals • Suitable for use in ELISA (unless stated otherwise) • Lyophilized • Produced in cell culture (unless stated otherwise) K67138M * Recognizes the C-terminus a.a. 1165-1186, also works in IB, ICC and IP P24100M * Does not cross-react with v-erb-B, also works in IHC and FC P24200M * Does not cross-react with v-erb-B, also works in IHC and FC K67190M * Recognizes site phosphorylated at Serine 1047, also works in IB, ICC and IP K67902M * Recognizes site phosphorylated at Tyrosine 1173, also works in IB, ICC and IP K67123M * Recognizes site phosphorylated at Tyrosine 845, also works in IB Antigens VTI880 • Recombinant EGF (P. pastoris)

Disialoganglioside GD2

Disialoganglioside GD2 is a sialic-acid bearing glycolipid that is expressed on the surface of all mammalian cells. Studies have shown that they are important target antigens for antibody dependent cellular cytotoxicity of human melanoma and neuroblastoma cells. The relatively tumor-specific expression of GD2 makes it a suitable target for immunotherapy with monoclonal antibodies or with artificial T-cell receptors. Antigens A86168H • Native antigen from human brain • > 98% pure (HPTLC), lyophilized

• Suitable for use in WB • 95% pure (SDS-PAGE)

Elastase

VTI882

• Recombinant EGF (P. pastoris) • Suitable for use in WB • > 95% pure (SDS-PAGE)

Elastase is a serine proteinase and specifically the neutrophil form of Elastase is 218 amino acids long, with two asparagine- linked carbohydrate chains. It is secreted by neutrophils and macrophages during inflammation to destroy bacteria and host tissue. Research has shown that neutrophil Elastase can speed up the progression of cancer and the amount of immunoreactive neutrophil Elastase in tumor tissue is an independent prognostic indicator of patients with breast cancer and lung cancer. Antigens A01683H • Native antigen from human neutrophils • Suitable for use in ELISA and WB • 90% pure SDS-PAGE (Chromatography) A50145H • Native antigen from human neutrophils • > 95% pure (SDS-PAGE), lyophilized

Polyclonals CATALOG

SOURCE FORMAT APPLICATION

K90052C

Sheep

Purified

WB

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14 | Cancer & Tumor Markers for Assay Development

Cancer & Tu or Markers - Reagents for Assay Development

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